纯钛表面载骨碎补提取物涂层的制备与性能
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摘要
为了提高纯Ti的生物活性和抗感染性,采用微弧氧化(UMAO)制备多孔涂层,并以植酸(PA)为偶联剂将骨碎补提取物(ERD)载入多孔涂层中,并分析涂层结构、形貌及性能。结果表明,随着ERD浓度的提高,纳米颗粒增多,有PO_4~(3-),P_2O_7~(4-)和O=P-O-生成;载药12.5 g/L的膜层的摩擦系数较低,为亲水涂层;相对于未载药涂层,载药膜层的电位提高了0.33～0.45 V,自腐蚀电流降低1个数量级;模拟体液浸泡有羟基磷灰石(HA)生成。纯钛表面通过超声微弧氧化,植酸偶联载药涂层的耐蚀性、结合力和生物活性均有提高。
To improve the bioactivity of surface of titanium and reduce infection rate of implantation,porous coatings were prepared by ultrasonic micro arc oxidation(UMAO)and phytic-acid-coupled extract of rhizoma drynariae(ERD)was loaded in the coatings.Besides,the structure,surface morphology and performance of the coatings were investigated.The results indicate that nano particles of drug loading increase in number with the increasing of ERD concentration.The surface of the coatings produce PO_4~(3-),P_2O_7~(4-)and O=P-O-.The friction coefficient of the coating carrying ERD with concentration of 12.5 g/L is lower.Also,this coating is hydrophilic.The potential increases by 0.33～0.45 V and self-corrosion current decreases by an order of magnitude for the coatings carrying ERD.The coatings produce HA after soaking in SBF for 7 d.In conclusion,the corrosion resistance,binding force and bioactivity are improved by drug loading coupled with phytic acid after MAO on the pure titanium.
To improve the bioactivity of surface of titanium and reduce infection rate of implantation,porous coatings were prepared by ultrasonic micro arc oxidation(UMAO)and phytic-acid-coupled extract of rhizoma drynariae(ERD)was loaded in the coatings.Besides,the structure,surface morphology and performance of the coatings were investigated.The results indicate that nano particles of drug loading increase in number with the increasing of ERD concentration.The surface of the coatings produce PO_4~(3-),P_2O_7~(4-)and O=P-O-.The friction coefficient of the coating carrying ERD with concentration of 12.5 g/L is lower.Also,this coating is hydrophilic.The potential increases by 0.33～0.45 V and self-corrosion current decreases by an order of magnitude for the coatings carrying ERD.The coatings produce HA after soaking in SBF for 7 d.In conclusion,the corrosion resistance,binding force and bioactivity are improved by drug loading coupled with phytic acid after MAO on the pure titanium.
引文
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[2]Chen Xiwen(陈西文),Zhu Zhimin(朱智敏).Chinese Journal of Practical Stomatology(中国实用口腔科杂志)[J],2014,7(3):188
[3]Xu Lin(徐琳),Ding Jianning(丁建宁),Xu Xiaojing(许晓静)et al.Rare Metal Materials and Engineering(稀有金属材料与工程)[J],2017,46(1):127
[4]Lu Ran(卢燃),Chen Su(陈溯),Zhang Zhenting(张振庭).Chinese Journal of Prosthodontics(口腔颌面修复学杂志)[J],2017,18(3):173
[5]Han Aifang(韩艾芳),Huang Baoxin(黄宝鑫),Deng Dongmei(邓动梅)et al.Journal of Clinical Stomatology(临床口腔杂志)[J],2014,30(5):283
[6]Sun Zhixin(孙志新),Zhang Yuntao(张云涛).International Journal of Stomatology(国际口腔医学杂志)[J],2015,42(2):221
[7]Yang Xiaofeng(杨晓丰),Liu Fan(刘帆),Liu Yi(刘奕)et al.Journal of Clinical Stomatology(临床口腔医学杂志)[J],2016,32(9):569
[8]Wang L,Xie L,Lv Y et al.Acta Materialia[J],2017,23(1):87
[9]Ding Z,Zhang C,Xie L et al.Metallurgical&Materials Transactions A[J],2016,47(12):5675
[10]Zhang Tianshou(张天首),Ying Shun(应頔),Zhang Yidi(张一迪)et al.Journal of Modern Stomatology(现代口腔医学杂志)[J],2015,29(6):367
[11]Pan Y K,Chen C Z,Wang D G et al.Materials Chemistry&Physics[J],2013,141(2-3):842
[12]Wang Y,Yu H,Chen C et al.Materials&Design[J],2015,85:640
[13]Gao X,Li W,Yan R et al.Surface&Coatings Technology[J],2017,325:248
[14]Jiang Shuqin(蒋书琴),Guo Ruiguang(郭瑞光),Jiang Xiao(蒋晓).Materials Protection(材料保护)[J],2015,48(6):24
[15]Niu Linqing(牛林清),Guo Ruiguang(郭瑞光).Materials Protection(材料保护)[J],2016,49(12):30
[16]Yu Zeteng(于泽腾),Hu Huili(胡会利),Han Xue(韩雪)et al.Materials Protection(材料保护)[J],2017,50(5):45
[17]Cheng Maogao(程茂高),Qiao Qingmei(乔卿梅),Wei Xiaomin(韦小敏)et al.Lishizhen Medicine and Materia Medica Research(时珍国医国药)[J],2016,27(5):1132
[18]Sui Hongfei(隋洪飞),Yin Shiqiang(尹世强),Zou Aiying(邹爱英).Chinese Traditional and Herbal Drugs(中草药)[J],2015,46(20):2992
[19]Huang Beixiong(黄北雄),Dai Boan(戴柏桉).China Pharmacy(中国药房)[J],2016,27(27):3875
[20]Zhao Wenhua(招文华),Shen Gengyang(沈耿杨),Ren Hui(任辉)et al.Chinese Journal of Osteoporosis(中国骨质疏松杂志)[J],2017,23(1):122
[21]Yang Tonggang(杨同岗),Wang Xiaoying(王晓英),Hao Yanke(郝延科)et al.Shaanxi Journal of Traditional Chinese Medicine(陕西中医)[J],2017,38(5):677
[22]Deng Zhansheng(邓展生),Zhang Xuan(张璇),Zou Dongqing(邹冬青)et al.China Journal of Modern Medicine(中国现代医学杂志)[J],2005,16:2426
[23]Zhang Di(张镝),Jia Zhijie(贾志杰),Tian Yongli(田永利)et al.Chinese Journal of Tissue Engineering Research(中国组织工程研究与临床康复)[J],2010,14(37):6947
[24]Kuang Lihua(匡立华),Jia Qingyun(贾庆运),Tan Guoqing(谭国庆)et al.Chinese Journal of Osteoporosis(中国骨质疏松杂志)[J],2015,21(8):1000
[25]Shi Xiaozhi(史晓治),Zhao Yongfang(赵咏芳),Guo Hailing(郭海玲).Acta Chinese Medicine(中医学报)[J],2015,30(5):693
[26]Dai H,Wang N,Wang D et al.Chemical Engineering Journal[J],2016,299:150
[27]Zhang R,Cai S,Xu G et al.Applied Surface Science[J],2014,313:896
[28]Wang Yuxiang(汪玉祥),Zhou Sumin(周苏闽),Bao Zhigang(包志刚)et al.Guangdong Chemical Industry(广东化工)[J],2010,37(3):83
[29]Marques I D,Alfaro M F,Cruz N C et al.Journal of the Mechanical Behavior of Biomedical Materials[J],2016,60:8
[30]Prakash C G J,Raj C C,Prasanth R.Journal of Colloid&Interface Science[J],2017,496:300
[31]Byon E,Jeong Y,Takeuchi A et al.Surface&Coatings Technology[J],2007,201(9-11):5651
[32]Zhao G L,Xia L,Zhong B et al.Transactions of Nonferrous Metals Society of China[J],2015,25(4):1151
[33]Zhao W,Lema?tre J,Bowen P.Acta Biomaterialia[J],2017,53:506