补脑息风止痉汤联合盐酸苯海索治疗帕金森病观察
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摘要
目的:探究补脑息风止痉汤联合盐酸苯海索治疗帕金森病中的价值。方法:以116例帕金森氏病患者为研究对象,随机分为观察组(A组,58例)和对照组(B组,58例)。予B组常规西药治疗辅以盐酸苯海索口服治疗,再此基础上予A组患者补脑息风止痉汤。观察并比较两组临床疗效、帕金森综合评分量表(UPDRS)评分、药物安全性情况。结果:治疗后,两组均取得较好的治疗效果,A组临床有效率更高(P<0.05);与B组相比,A组UPDRS-1、UPDRS-2及UPDRS-3评分均显著降低(P<0.05),A组患者不良反应种类及不良反应发生率显著降低(P<0.05)。结论:补脑息风止痉汤联合盐酸苯海索治疗帕金森病可显著提高对帕金森患者的治疗效果、减少药物不良反应,具有极高的临床应用价值。
Objective: To explore the value of Bunao Xifeng Zhijing Decoction combined with trihexyphenidyl hydrochloride used in the treatment of Parkinson's disease. Methods: Totally 116 patients with Parkinson's disease were selected and randomly divided into observation group(group A, 58 cases) and control group(group B, 58 cases). Patients in group B were treated with conventional western medicine combined with trihexyphenidyl hydrochloride. And based on that, patients of group A were given Bunao Xifeng Zhijing Decoction. The clinical efficacy, Parkinson comprehensive score scale(UPDRS) and drug safety were observed and compared between the two groups. Results: After treatment, all the two groups had better therapeutic effect, and the clinical effective rate of group A was higher(P<0.05). Compared with group B, the scores of UPDRS-1, UPDRS-2 and UPDRS-3 in group A were significantly decreased(P<0.05), and the incidence of adverse reactions and adverse reactions in group A decreased significantly(P<0.05). Conclusion: Bunao Xifeng Zhijing Decoction combined with trihexyphenidyl hydrochloride used in the treatment of Parkinson's disease can significantly improve the therapeutic effect and reduce adverse drug reactions. It has a high clinical value.
Objective: To explore the value of Bunao Xifeng Zhijing Decoction combined with trihexyphenidyl hydrochloride used in the treatment of Parkinson's disease. Methods: Totally 116 patients with Parkinson's disease were selected and randomly divided into observation group(group A, 58 cases) and control group(group B, 58 cases). Patients in group B were treated with conventional western medicine combined with trihexyphenidyl hydrochloride. And based on that, patients of group A were given Bunao Xifeng Zhijing Decoction. The clinical efficacy, Parkinson comprehensive score scale(UPDRS) and drug safety were observed and compared between the two groups. Results: After treatment, all the two groups had better therapeutic effect, and the clinical effective rate of group A was higher(P<0.05). Compared with group B, the scores of UPDRS-1, UPDRS-2 and UPDRS-3 in group A were significantly decreased(P<0.05), and the incidence of adverse reactions and adverse reactions in group A decreased significantly(P<0.05). Conclusion: Bunao Xifeng Zhijing Decoction combined with trihexyphenidyl hydrochloride used in the treatment of Parkinson's disease can significantly improve the therapeutic effect and reduce adverse drug reactions. It has a high clinical value.
引文
[1] 张金枝,刘真真,林燕.盐酸苯海索联合吡贝地尔治疗帕金森病的效果及安全性研究[J].中外医疗,2017,36(14):14-16.
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[3] 张文,袁薇,谢华,等.吡贝地尔联合左旋多巴治疗帕金森病的Meta分析[J].中国现代应用药学,2016,33(10):1323-1328.
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[5] 高筱雅,陈晖,王慧杰.复方卡比多巴片联合补脑熄风止痉汤治疗帕金森病疗效及对患者血清炎症因子水平的影响[J].中国药师,2016,19(5):910-913.
[6] 谭晓琳,张立新,张志强,等.血管性帕金森综合征患者认知与运动功能相关性分析[J].现代医学,2017,45(10):1408-1412.
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[8] 高晓嵘,李娜,薛艺东,等.帕金森病患者外周血促炎症物质与抑郁、焦虑症状的相关性[J].国际精神病学杂志,2015,42(6):60-63.
[9] 高中宝,王洁,王炜,等.帕金森病诊断与治疗新进展[J].中国现代神经疾病杂志,2015,15(10):777-781.
[10] 黄秀清,赵晓华,许健,等.左旋千金藤啶碱抑制Tau蛋白过度磷酸化改善帕金森病认知症状的相关机制研究[J].中国现代应用药学,2018,35(5):648-652.
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[12] 李成刚,李成国.帕金森病运动并发症治疗进展[J].川北医学院学报,2017,32(4):643-648.
[13] 胡雅琼,罗理勇,曾亮.茶叶提取物对帕金森病的防治作用研究进展[J].中草药,2014,45(9):1342-1348.
[14] 林晓光.盐酸苯海索治疗50例帕金森病及其综合征的震颤观察[J].医学理论与实践,2013,26(22):2989-2990.
[15] 顾亮亮,付国惠,张保朝,等.葛根素注射液联合多奈哌齐治疗帕金森病的疗效观察[J].现代药物与临床,2018,33(5):1230-1233.
[16] 于磊,李绍旦,刘毅,等.中药口服治疗帕金森病的疗效述评[J].中华中医药学刊,2016,34(3):563-565.
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[18] 朱会杰,曹林,唐波,等.熄风汤对帕金森病模型小鼠多巴胺能神经元的影响[J].东南大学学报(医学版),2016,35(1):11-16.
[19] 黄晓林.育阴宁神汤中药熏蒸治疗帕金森病睡眠障碍的疗效观察[J].中医临床研究,2018,10(5):64-65.
[20] 杨卜凡,杨应成.自拟参藤除颤汤治疗帕金森病临床体会[J].中国民族民间医药,2018,27(3):87-89.
[21] 王妮娜.地黄饮子合芍药甘草汤治疗帕金森病疗效观察[J].山西中医,2018,34(2):11-12.
[22] 李梦頔,黄世敬.从“气虚络瘀”论治帕金森病[J].中医研究,2018,31(2):8-10.
[23] 陈敏,王祎晟,张晓菁.益气健脾汤联合针刺治疗气虚型帕金森病病人便秘的临床疗效[J].中西医结合心脑血管病杂志,2018,16(2):143-146.
[24] 马丹丹,雒晓东,郑春叶.柴甘解忧汤治疗帕金森病抑郁35例[J].实用医学杂志,2018,34(1):144-147.
[25] 赵贝贝,崔晓峰,占大权,等.加味芍药甘草汤治疗早中期僵直少动型帕金森病的临床观察[J].内蒙古中医药,2017,36(Z2):97-99.
[26] 陈宇,李燕.天麻钩藤饮合芍药甘草汤加减治疗肝肾阴虚型帕金森病36例[J].福建中医药,2017,48(6):52-53.
[27] 曹旸,徐凡叶,问莉娜,等.补益肝肾汤联合美多巴治疗帕金森患者的临床效果及对认知功能的影响[J].现代生物医学进展,2017,17(32):6308-6311.
[28] 林煜,彭慕立,苏赤,等.多巴丝肼联合归脾汤加减治疗老年帕金森病心脾两虚型失眠的效果分析[J].黑龙江中医药,2017,46(6):6-7.
[29] 黄宁静,Wei Jianning,李文涛.止颤汤参与帕金森病大鼠自噬途径中P62调节α-突触核蛋白的研究[J].中西医结合心脑血管病杂志,2017,15(21):2689-2692.
[30] 李金容,陈倩,陶文强,等.二白汤治疗帕金森病相关便秘的临床疗效观察[J].河北中医,2017,39(9):1337-1339.
[31] 蔡丽,刘毅,李文涛,等.止颤汤联合西药治疗帕金森病43例随机双盲对照研究[J].江苏中医药,2017,49(11):33-35.
[32] 许程燕.滋阴息风汤联合美多芭治疗肝肾阴虚型帕金森病非运动症状的临床疗效研究[J].中医临床研究,2017,9(30):13-14,28.
[33] 吴之煌.补脑熄风止痉汤治疗帕金森病的临床疗效观察[J].中国现代医生,2017,55(29):116-118.
[34] 李金容,陈倩,陶文强,等.二白汤治疗帕金森病相关便秘的临床疗效观察[J].河北中医,2017,39(9):1337-1339.
[35] 马锋.中西医结合治疗帕金森病临床观察[J].实用中医药杂志,2017,33(9):1044-1045.
[36] 黄宁静,陆小青.DARPP-32磷酸化与止颤汤改善大鼠帕金森病运动并发症的研究[J].中西医结合心脑血管病杂志,2017,15(17):2110-2113.
[37] 孙平,洪亮,杨言府.滋肝养肾复脉汤对帕金森病患者认知功能及血清尿酸和同型半胱氨酸含量的影响[J].中医药导报,2017,23(12):66-69.
[2] 顾超,沈婷,袁灿兴,等.地黄益智方联合盐酸多奈哌齐治疗帕金森病痴呆临床研究[J].四川中医,2016,34(9):107-111.
[3] 张文,袁薇,谢华,等.吡贝地尔联合左旋多巴治疗帕金森病的Meta分析[J].中国现代应用药学,2016,33(10):1323-1328.
[4] 王峰.盐酸苯海索联合吡贝地尔治疗帕金森病的效果及安全性分析[J].中国实用神经疾病杂志,2016,19(14):112-114.
[5] 高筱雅,陈晖,王慧杰.复方卡比多巴片联合补脑熄风止痉汤治疗帕金森病疗效及对患者血清炎症因子水平的影响[J].中国药师,2016,19(5):910-913.
[6] 谭晓琳,张立新,张志强,等.血管性帕金森综合征患者认知与运动功能相关性分析[J].现代医学,2017,45(10):1408-1412.
[7] 刘疏影,陈彪.帕金森病流行现状[J].中国现代神经疾病杂志,2016,16(2):98-101.
[8] 高晓嵘,李娜,薛艺东,等.帕金森病患者外周血促炎症物质与抑郁、焦虑症状的相关性[J].国际精神病学杂志,2015,42(6):60-63.
[9] 高中宝,王洁,王炜,等.帕金森病诊断与治疗新进展[J].中国现代神经疾病杂志,2015,15(10):777-781.
[10] 黄秀清,赵晓华,许健,等.左旋千金藤啶碱抑制Tau蛋白过度磷酸化改善帕金森病认知症状的相关机制研究[J].中国现代应用药学,2018,35(5):648-652.
[11] 曹开谊.盐酸苯海索治疗帕金森病与帕金森综合征探究[J].中国处方药,2015,13(5):84-85.
[12] 李成刚,李成国.帕金森病运动并发症治疗进展[J].川北医学院学报,2017,32(4):643-648.
[13] 胡雅琼,罗理勇,曾亮.茶叶提取物对帕金森病的防治作用研究进展[J].中草药,2014,45(9):1342-1348.
[14] 林晓光.盐酸苯海索治疗50例帕金森病及其综合征的震颤观察[J].医学理论与实践,2013,26(22):2989-2990.
[15] 顾亮亮,付国惠,张保朝,等.葛根素注射液联合多奈哌齐治疗帕金森病的疗效观察[J].现代药物与临床,2018,33(5):1230-1233.
[16] 于磊,李绍旦,刘毅,等.中药口服治疗帕金森病的疗效述评[J].中华中医药学刊,2016,34(3):563-565.
[17] 郭莉.补脑息风止痉汤治疗帕金森病的临床观察[J].中国中医药现代远程教育,2018,16(5):108-109.
[18] 朱会杰,曹林,唐波,等.熄风汤对帕金森病模型小鼠多巴胺能神经元的影响[J].东南大学学报(医学版),2016,35(1):11-16.
[19] 黄晓林.育阴宁神汤中药熏蒸治疗帕金森病睡眠障碍的疗效观察[J].中医临床研究,2018,10(5):64-65.
[20] 杨卜凡,杨应成.自拟参藤除颤汤治疗帕金森病临床体会[J].中国民族民间医药,2018,27(3):87-89.
[21] 王妮娜.地黄饮子合芍药甘草汤治疗帕金森病疗效观察[J].山西中医,2018,34(2):11-12.
[22] 李梦頔,黄世敬.从“气虚络瘀”论治帕金森病[J].中医研究,2018,31(2):8-10.
[23] 陈敏,王祎晟,张晓菁.益气健脾汤联合针刺治疗气虚型帕金森病病人便秘的临床疗效[J].中西医结合心脑血管病杂志,2018,16(2):143-146.
[24] 马丹丹,雒晓东,郑春叶.柴甘解忧汤治疗帕金森病抑郁35例[J].实用医学杂志,2018,34(1):144-147.
[25] 赵贝贝,崔晓峰,占大权,等.加味芍药甘草汤治疗早中期僵直少动型帕金森病的临床观察[J].内蒙古中医药,2017,36(Z2):97-99.
[26] 陈宇,李燕.天麻钩藤饮合芍药甘草汤加减治疗肝肾阴虚型帕金森病36例[J].福建中医药,2017,48(6):52-53.
[27] 曹旸,徐凡叶,问莉娜,等.补益肝肾汤联合美多巴治疗帕金森患者的临床效果及对认知功能的影响[J].现代生物医学进展,2017,17(32):6308-6311.
[28] 林煜,彭慕立,苏赤,等.多巴丝肼联合归脾汤加减治疗老年帕金森病心脾两虚型失眠的效果分析[J].黑龙江中医药,2017,46(6):6-7.
[29] 黄宁静,Wei Jianning,李文涛.止颤汤参与帕金森病大鼠自噬途径中P62调节α-突触核蛋白的研究[J].中西医结合心脑血管病杂志,2017,15(21):2689-2692.
[30] 李金容,陈倩,陶文强,等.二白汤治疗帕金森病相关便秘的临床疗效观察[J].河北中医,2017,39(9):1337-1339.
[31] 蔡丽,刘毅,李文涛,等.止颤汤联合西药治疗帕金森病43例随机双盲对照研究[J].江苏中医药,2017,49(11):33-35.
[32] 许程燕.滋阴息风汤联合美多芭治疗肝肾阴虚型帕金森病非运动症状的临床疗效研究[J].中医临床研究,2017,9(30):13-14,28.
[33] 吴之煌.补脑熄风止痉汤治疗帕金森病的临床疗效观察[J].中国现代医生,2017,55(29):116-118.
[34] 李金容,陈倩,陶文强,等.二白汤治疗帕金森病相关便秘的临床疗效观察[J].河北中医,2017,39(9):1337-1339.
[35] 马锋.中西医结合治疗帕金森病临床观察[J].实用中医药杂志,2017,33(9):1044-1045.
[36] 黄宁静,陆小青.DARPP-32磷酸化与止颤汤改善大鼠帕金森病运动并发症的研究[J].中西医结合心脑血管病杂志,2017,15(17):2110-2113.
[37] 孙平,洪亮,杨言府.滋肝养肾复脉汤对帕金森病患者认知功能及血清尿酸和同型半胱氨酸含量的影响[J].中医药导报,2017,23(12):66-69.