中风偏瘫病人左侧额顶网络的静息态fMRI研究
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摘要
目的应用静息态功能磁共振技术对中风偏瘫病人左侧额顶网络的特征性变化进行初步研究。方法对15例左侧偏瘫病人及与之性别和年龄相匹配的15名健康受试者进行静息态功能磁共振成像,应用独立成分分析法提取额顶网络成分进行统计分析。结果与健康受试者相比,中风偏瘫病人的左侧额顶网络中左岛叶、左中央前回、左额下回、左额中回、左中央后回等脑区的功能连接度均增强。结论静息态下中风偏瘫病人的左侧额顶网络存在多个特定脑区功能连接度增强的特征性变化,这可能是左侧中风偏瘫病人对侧代偿的表现,这为从脑功能层面探讨脑功能重塑机制提供依据。
Objective To study the change of left frontoparietal network( LFPN) in stroke patients with hemiplegia. Methods Fifteen stroke patients with hemiplegia were recruited to undergo resting-state functional magnetic resonance imaging( f MRI) scanning. Another 15 matched healthy subjects underwent same scanning for comparison. We analyzed the functional connectivity( FC) of the LFPN between stroke patients and healthy subjects by using the independent component analysis. Results Compared with healthy subjects,the stroke patients showed significantly increased FC in the LFPN. Conclusion The enhanced FC of the LFPN provided further evidence for the compensatory role played by the contralesional hemisphere during motor function recovery.
Objective To study the change of left frontoparietal network( LFPN) in stroke patients with hemiplegia. Methods Fifteen stroke patients with hemiplegia were recruited to undergo resting-state functional magnetic resonance imaging( f MRI) scanning. Another 15 matched healthy subjects underwent same scanning for comparison. We analyzed the functional connectivity( FC) of the LFPN between stroke patients and healthy subjects by using the independent component analysis. Results Compared with healthy subjects,the stroke patients showed significantly increased FC in the LFPN. Conclusion The enhanced FC of the LFPN provided further evidence for the compensatory role played by the contralesional hemisphere during motor function recovery.
引文
[1]Lozano R,Naghavi M,Foreman K,et al.Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010:a systematic analysis for the Global Burden of Disease Study 2010[J].Lancet,2012,380(9859):2095-2128.
[2]中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380.
[3]Raichle ME.The restless brain[J].Brain Connect,2011,1(1):3-12.
[4]Iidaka T,Matsumoto A,Nogawa J,et al.Frontoparietal network involved in successful retrieval from episodic memory.Spatial and temporal analyses using f MRI and ERP[J].Cereb Cortex,2006,16(9):1349-1360.
[5]Seeley WW,Menon V,Schatzberg AF,et al.Dissociable intrinsic connectivity networks for salience processing and executive control[J].J Neurosci,2007,27(9):2349-2356.
[6]Li K,Zhang Y,Ning Y,et al.The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients[J].J Headache Pain,2015,16:33.
[7]崔丽英.肌萎缩侧索硬化症认知损害的磁共振成像研究[D].北京:北京协和医学院,2014.
[8]Liu T,Li JJ,Zhao ZY,et al.Altered spontaneous brain activity in betel quid dependence:a resting-statefunctional magnetic resonance imaging study[J].Medicine(Baltimore),2016,95(5):e2638.
[9]Wang L,Yu C,Chen H,et al.Dynamic functional reorganization of the motor execution network after stroke[J].Brain,2010,133(4):1224-1238.
[10]郎奕,崔方圆,李匡时,等.头针对脑梗死后脑灰质损伤干预作用的影像学研究[J].中国中西医结合杂志,2016,36(3):294-299.
[11]Zhang Y,Li KS,Ren Y,et al.Acupuncture modulates the functional connectivity of the default mode network in stroke patients[J].Evidence-Based Complementary and Alternative Medicine,2014,2014:e765413.
[12]Golestani AM,Tymchuk S,Demchuk A,et al.Longitudinal evaluation of resting-state FMRI after acute stroke with hemiparesis[J].Neurorehabil Neural Repair,2013,27(2):153-163.
[13]Xu H,Qin W,Chen H,et al.Contribution of the resting-state functional connectivity of the contralesional primary sensorimotorcortex to motor recovery after subcortical stroke[J].PLo S One,2014,9(1):e84729.
[14]Liu J,Qin W,Zhang J,et al.Enhanced interhemispheric functional connectivity compensates for anatomical connection damages in subcortical stroke[J].Stroke,2015,46(4):1045-1051.
[15]Wang LE,Tittgemeyer M,Imperati D,et al.Degeneration of corpus callosum and recovery of motorfunction after stroke:a multimodal magnetic resonance imaging study[J].Hum Brain Mapp,2012,33(12):2941-2956.
[2]中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380.
[3]Raichle ME.The restless brain[J].Brain Connect,2011,1(1):3-12.
[4]Iidaka T,Matsumoto A,Nogawa J,et al.Frontoparietal network involved in successful retrieval from episodic memory.Spatial and temporal analyses using f MRI and ERP[J].Cereb Cortex,2006,16(9):1349-1360.
[5]Seeley WW,Menon V,Schatzberg AF,et al.Dissociable intrinsic connectivity networks for salience processing and executive control[J].J Neurosci,2007,27(9):2349-2356.
[6]Li K,Zhang Y,Ning Y,et al.The effects of acupuncture treatment on the right frontoparietal network in migraine without aura patients[J].J Headache Pain,2015,16:33.
[7]崔丽英.肌萎缩侧索硬化症认知损害的磁共振成像研究[D].北京:北京协和医学院,2014.
[8]Liu T,Li JJ,Zhao ZY,et al.Altered spontaneous brain activity in betel quid dependence:a resting-statefunctional magnetic resonance imaging study[J].Medicine(Baltimore),2016,95(5):e2638.
[9]Wang L,Yu C,Chen H,et al.Dynamic functional reorganization of the motor execution network after stroke[J].Brain,2010,133(4):1224-1238.
[10]郎奕,崔方圆,李匡时,等.头针对脑梗死后脑灰质损伤干预作用的影像学研究[J].中国中西医结合杂志,2016,36(3):294-299.
[11]Zhang Y,Li KS,Ren Y,et al.Acupuncture modulates the functional connectivity of the default mode network in stroke patients[J].Evidence-Based Complementary and Alternative Medicine,2014,2014:e765413.
[12]Golestani AM,Tymchuk S,Demchuk A,et al.Longitudinal evaluation of resting-state FMRI after acute stroke with hemiparesis[J].Neurorehabil Neural Repair,2013,27(2):153-163.
[13]Xu H,Qin W,Chen H,et al.Contribution of the resting-state functional connectivity of the contralesional primary sensorimotorcortex to motor recovery after subcortical stroke[J].PLo S One,2014,9(1):e84729.
[14]Liu J,Qin W,Zhang J,et al.Enhanced interhemispheric functional connectivity compensates for anatomical connection damages in subcortical stroke[J].Stroke,2015,46(4):1045-1051.
[15]Wang LE,Tittgemeyer M,Imperati D,et al.Degeneration of corpus callosum and recovery of motorfunction after stroke:a multimodal magnetic resonance imaging study[J].Hum Brain Mapp,2012,33(12):2941-2956.