精神分裂症首次发病患者额顶网络功能连接与面孔情绪识别能力的关系
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摘要
目的:探讨首发精神分裂症患者在静息状态下额顶网络的功能连接特点,及其与面孔情绪识别能力的相关性。方法:对37例首发未用药的精神分裂症患者(患者组)和30名年龄、性别、利手、受教育程度与患者相匹配的健康者(正常对照组)进行静息态功能磁共振(f MRI)扫描,收集两组的一般临床特征,并采用面孔情绪测试评价被试的面孔情绪认知功能;以双侧背外侧前额叶(DLPFC)为种子点比较两组间额顶网络功能连接的差异,并分析与面孔情绪认知功能的相关性。结果:与正常对照组相比,患者组DLPFC与左顶下小叶(t=-3.243,Alphasim校正P<0.05)、左额下回(t=-3.151,Alphasim校正P<0.05)、左额中回(t=-3.151,Alphasim校正P<0.05)、双侧尾状核(t=-4.325,Alphasim校正P<0.05)、左颞中回(t=-3.120,Alphasim校正P<0.05)的功能连接减低;与双侧扣带回中部(t=2.731,Alphasim校正P<0.05)、右中央前回(t=3.991,Alphasim校正P<0.05)、右岛叶(t=3.991,Alphasim校正P<0.05)功能连接增强。患者组额-顶通路的功能连接与面孔情绪认知障碍呈正相关(r=0.501,P<0.05)。结论:首发精神分裂症患者额顶网络的功能连接存在异常,其中DLPFC-顶下小叶通路的功能连接降低可能影响患者面孔情绪识别能力。
Objective: To explore the feature of frontoparietal network functional connectivity( FPN-fc) in first-episode schizophrenia by using functional magnetic resonance imaging( f MRI) technique,and gain the correlation between social cognition and the alteration of connectivity. Method: Thirty-seven first-episode schizophrenia( FES) patients,and 30 age / gender / education matched healthy controls were examined by f MRI scans,collecting resting-state f MRI scans and facial emotion cognition test results. Dorsolateral prefrontal cortex( DLPFC) seed-based correlation analyses were used to estimate FPN-fc group differences. Results: Compared with the control group,functional connectivity between the DLPFC and a set of regions decreased in patients group,these regions were: left inferior parietal lobule( t =- 3. 243,Alphasim correction P < 0. 05),left inferior frontal gyrus( t =- 3. 151,Alphasim correction P < 0. 05),left middle frontal gyrus( t =- 3. 151,Alphasim correction P < 0. 05),bilateral caudate( t =- 4. 325,Alphasim correction P < 0. 05),left middle temporal gyrus( t =- 3. 120,Alphasim correction P < 0. 05); functional connectivity between the DLPFC and bilateral middle of cingulate( t = 2. 731,Alphasim correction P < 0. 05),right precentral gyrus( t = 3. 991,Alphasim correction P < 0. 05),right insula( t = 3. 991,Alphasim correction P < 0. 05) enhancement in patients group. Reduced DLPFC-inferior parietal lobule functional connectivity was associated with worse facial emotion cognition( r =0. 501,P < 0. 05) in patients group. Conclusion: Our results indicated that abnormal FPN-fc may be widely distributed in first-episode schizophrenia patients. Lower FPN-fc was associated with lower emotion processing.
Objective: To explore the feature of frontoparietal network functional connectivity( FPN-fc) in first-episode schizophrenia by using functional magnetic resonance imaging( f MRI) technique,and gain the correlation between social cognition and the alteration of connectivity. Method: Thirty-seven first-episode schizophrenia( FES) patients,and 30 age / gender / education matched healthy controls were examined by f MRI scans,collecting resting-state f MRI scans and facial emotion cognition test results. Dorsolateral prefrontal cortex( DLPFC) seed-based correlation analyses were used to estimate FPN-fc group differences. Results: Compared with the control group,functional connectivity between the DLPFC and a set of regions decreased in patients group,these regions were: left inferior parietal lobule( t =- 3. 243,Alphasim correction P < 0. 05),left inferior frontal gyrus( t =- 3. 151,Alphasim correction P < 0. 05),left middle frontal gyrus( t =- 3. 151,Alphasim correction P < 0. 05),bilateral caudate( t =- 4. 325,Alphasim correction P < 0. 05),left middle temporal gyrus( t =- 3. 120,Alphasim correction P < 0. 05); functional connectivity between the DLPFC and bilateral middle of cingulate( t = 2. 731,Alphasim correction P < 0. 05),right precentral gyrus( t = 3. 991,Alphasim correction P < 0. 05),right insula( t = 3. 991,Alphasim correction P < 0. 05) enhancement in patients group. Reduced DLPFC-inferior parietal lobule functional connectivity was associated with worse facial emotion cognition( r =0. 501,P < 0. 05) in patients group. Conclusion: Our results indicated that abnormal FPN-fc may be widely distributed in first-episode schizophrenia patients. Lower FPN-fc was associated with lower emotion processing.
引文
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[3]Tsui CF,Huang J,Lui SSY,et al.Facial emotion perception abnormality in patients with early schizophrenia[J].Schizophrenia Research,2013,147(2-3):230-235.
[4]Fett AJ,Viechtbauer W,Dominguez M,et al.The relationship between neurocognition and social cognition with functional outcomes in schizophrenia:A meta-analysis[J].Neuroscience Biobehavioral Reviews,2011,35(3):573-588.
[5]Amminger GP,Schafer MR,Papageorgiou K,et al.Emotion recognition in individuals at clinical high-risk for schizophrenia[J].Schizophr Bull,2012,38(5):1030-1039.
[6]van Buuren M,Vink M,Rapcencu AE,et al.Exaggerated brain activation during emotion processing in unaffected siblings of patients with schizophrenia[J].Biological Psychiatry,2011,70(1):81-87.
[7]Spielberg JM,Miller GA,Engels AS,et al.Trait approach and avoidance motivation:lateralized neural activity associated with executive function[J].Neuroimage,2011,54(1):661-670.
[8]Su TW,Lan TH,Hsu TW,et al.Reduced neuro-integration from the dorsolateral prefrontal cortex to the whole brain and executive dysfunction in schizophrenia patients and their relatives[J].Schizophr Res,2013,148(1-3):50-58.
[9]Chang X,Shen H,Wang L,et al.Altered default mode and frontoparietal network subsystems in patients with schizophrenia and their unaffected siblings[J].Brain Res,2014,1562:87-99.
[10]Smith EE,Salat DH,Jeng J,et al.Correlations between MRI white matter lesion location and executive function and episodic memory[J].Neurology,2011,76(17):1492-1499.
[11]Peeters SCT,van Bronswijk S,van de Ven V,et al.Cognitive correlates of frontoparietal network connectivity'at rest'in individuals with differential risk for psychotic disorder[J].European Neuropsychopharmacology,2015,25(11):1922-1932.