骨形态发生蛋白7在女性生殖系统中的作用及其中医药干预研究进展
|
摘要
综述了骨形态发生蛋白7(BMP-7)在卵泡发育、卵巢甾体激素生成、卵巢细胞因子调控、子宫内膜蜕膜化及容受性改变、胚胎及胎盘发育等有关女性生殖的生物学过程的作用及中医药干预BMP-7的研究进展。结果表明BMP-7参与了以上多个与女性生殖有关的过程;中医药干预BMP-7目前仅局限于肾脏疾病和骨病的研究中。这些研究结果有助于理解女性生殖系统功能异常及女性不孕不育的机制,并利于拓展对中医妇科疾病发病机制的认识及开发治疗思路。
The influences of bone morphogenetic protein 7(BMP-7)in the aspects of biological processes of women reproductive system including follicular development,formation of the ovary steriod hormone,regulation of ovary cytokines,endometrial decidualization and endometrial receptivity regulation,and development of fetus and placenta as well as research progress in the intervention of BMP-7 with traditional Chinese medicine were reviewed.The results showed that BMP-7 participated in all of the above aspects of biological processes of women reproductive system,and now the intervention of BMP-7 with traditional Chinese medicine only targeted in kidney diseases and bone diseases.The research achievements will be beneficial to the understanding of pathogenesis in women reproductive functional disorder and infertility,and be helpful to the acquaintance of pathogenesis of gynecological disease and the expanding of therapeutic therapy in the field of traditional Chinese medicine.
The influences of bone morphogenetic protein 7(BMP-7)in the aspects of biological processes of women reproductive system including follicular development,formation of the ovary steriod hormone,regulation of ovary cytokines,endometrial decidualization and endometrial receptivity regulation,and development of fetus and placenta as well as research progress in the intervention of BMP-7 with traditional Chinese medicine were reviewed.The results showed that BMP-7 participated in all of the above aspects of biological processes of women reproductive system,and now the intervention of BMP-7 with traditional Chinese medicine only targeted in kidney diseases and bone diseases.The research achievements will be beneficial to the understanding of pathogenesis in women reproductive functional disorder and infertility,and be helpful to the acquaintance of pathogenesis of gynecological disease and the expanding of therapeutic therapy in the field of traditional Chinese medicine.
引文
[1] Celeste A J,Lannazzi J A,Taylor R C,et al. Identification of transforming growth factor beta family members present in boneinductive protein purified from bovine bone[J]. Proc Natl Acad Sci U S A,1990,87(24):9843.
[2] PostlethwaiteAE,RaghowR,StricklinG,etal.Osteogenicprotein-1,a bone morphogenic member of the TGF-beta superfamily,shares chemotactic but not fibrogenic properties with TGF-beta[J]. J Cell Physiol,1994,161(3):562.
[3] Chen P,Vukicevic S,Sampath T K,et al. Osteogenic protein-1promotes growth and maturation of chick sternal chondrocytes in serum-free cultures[J]. J Cell Sci,1995,108(1):105.
[4] Dudley A T,Lyons K M,Robertson E J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye[J]. Genes Dev,1995,9(22):2795.
[5] Tseng Y M, Kokkotou E, Schulz T J, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure[J]. Nature,2008,454:1000.
[6] Kobayashi A, Okuda H, Xing F, et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone[J]. Exp Med,2011,208(13):2641.
[7] Boon M R, van der Horst G, van der Pluijm G, et al. Bone morphogenetic protein 7:a broad spectrum growth factor with multiple target therapeutic potency[J]. Cytokine Growth Factor Rev,2011,22(4):221.
[8] Carreira A C,Lojudice F H,Halcsik E,et al. Bone morphogenetic proteins:facts,challenges,and future prospectives[J]. Dent Res,2014,93(4):335.
[9] Abir R,Ben-Haroush A,Melamed N,et al. Expression of bone morphogenetic proteins 4 and 7 and their receptors IA,IB,and II in human ovaries from fetuses and adults[J]. Fertil Steril,2008,89(5Suppl):1430.
[10] Erickson G F,Shimasaki S. The spatiotemporal expression of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle[J]. Reprod Biol Endocrinol,2003,1:9.
[11] Liu F,Ventura F,Doody J,et al. Human type II receptor for bone morphogenic proteins(BMPs):extension of the twokinase receptor model to the BMPs[J]. Mol Cell Biol,1995,15(7):3479.
[12] Shimizu T, Magata F, Abe Y, et al. Bone morphogenetic protein 4(BMP-4)and BMP-7 induce vascular endothelial growth factor expression in bovine granulosa cells[J]. Anim Sci J,2012,83(9):663.
[13] Chang H M, Qiao J, Leung C K P. Oocyte-somatic cell interactions in the human ovary:novel role of bone morphogenetic proteins and growth differentiation factors[J].Hum Reprod Update,2016,23(1):1.
[14] Lee W S, Otsuka F, Moore R K, et al. Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat[J]. Biol Reprod,2001,65(4):994.
[15] Lee W S, Yoon S J, Yoon T K, et al. Effects of bone morphogenetic protein-7(BMP-7)on primordial follicular growth in the mouse ovary[J]. Mol Reprod Dev,2004,69(2):159.
[16] Zhu G Q, Cui Y H, Wang Q L, et al. Bone morphogenetic proteins(BMP)2, 4, 6 and 7 affect ovarian follicular development through regulation of follicle-stimulating hormone receptor(FSHR)and luteinizing hormone receptor(LHR)expression in goat granulosa cells[J]. J Cell Biol Genetics,2013,3(1):14.
[17] Kayamori T, Kosaka N, Miyamoto A, et al. The differential pathways of bone morphogenetic protein(BMP)-4 and-7 in the suppression of the bovine granulosa[J]. Mol Cell Biochem,2009,323(1):161.
[18] Onagbesan O M, Bruggeman V, Van A P, et al. BMPs and BMPRs in chicken ovary and effects of BMP-4 and-7 on granulosa cell proliferation and progesterone production in vitro[J]. Am J Physiol Endocrinol Metab,2003,285:973.
[19] Shi J,Yoshino O,Osuga Y,et al. Bone morphogenetic protein7(BMP-7)increases the expression of follicle-stimulating hormone(FSH)receptor in human granulosa cells[J]. Fertil Steril,2010,93(4):1273.
[20] Shi J,Yoshino O,Osuga Y,et al. Growth differentiation factor3 is induced by bone morphogenetic protein 6(BMP-6)and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells[J]. Fertil Steril,2012,97(4):979.
[21] Zhang H,Klausen C,Zhu H,et al. BMP4 and BMP7 suppress StAR and progesterone production via ALK3 and SMAD1/5/8-SMAD4 in human granulosa-lutein cells[J]. Endocrinology,2015,156(11):4269.
[22] Juengel J L,Reader K L,Bibby A H,et al. The role of bone morphogenetic proteins 2,4,6 and 7 during ovarian follicular development in sheep:contrast to rat[J]. Reproduction,2006,131(3):501.
[23] Glister C,Kemp C F,Knight P G. Bone morphogenetic protein(BMP)ligands and receptors in bovine ovarian follicle cells:actions of BMP-4,-6, and-7 on granulosa cells and differential modulation of SMAD-1 phosphorylation by follistatin[J]. Reproduction,2004,127(2):239.
[24] Chang H M,Cheng J C,Leung P C. Theca-derived BMP4 and BMP7 down-regulate connexin 43 expression and decrease gap junction intercellular communication activity in immortalized human granulosa cells[J]. J Clin Endocrinol Metab,2013,98(3):E437.
[25] Chang H M,Cheng J C,Klausen C,et al. Recombinant BMP4and BMP7 increase activin A production by up-regulating inhibinβA subunit and furin expression in human granulosalutein cells[J]. J Clin Endocrinol Metab,2015,100(3):E375.
[26] Chang H M,Cheng J C,Fang L L,et al. Recombinant BMP4and BMP7 downregulate pentraxin 3 in human granulosa cells[J]. J Clin Endocrinol Metab,2015,100(3):365.
[27] Sovershaev T A, Unruh D, Sveinbj?rnsson B, et al. A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human monocytic cells[J]. Thromb Res,2016,147:24.
[28] Shimizu T, Jiang J Y, Iijima K, et al. Induction of follicular development by direct single injection of vascular endothelial growth factor gene fragments into the ovary of miniature gilts[J].Biol Reprod,2003,69(4):1388.
[29] Paria B C, Ma W, Tan J, et al. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors[J]. Proc Natl Acad Sci U S A,2001,98(3):1047.
[30] Kodama A, Yoshino O, Osugal Y, et al. Progesterone decreases bone morphogenetic protein(BMP)7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells[J]. Hum Reprod,2010,25(3):751.
[31] Monsivais D,Clementi C,Peng J,et al. BMP7 induces uterine receptivity and blastocyst attachment[J]. Endocrinology,2017,158(4):979.
[32] Takeda M,Otsuka F,Takahashi H,et al. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and-7 signaling in LβT2 gonadotrope cells[J]. Mol Cell Endocrinol,2012,348(1):147.
[33] Otani H, Otsuka F, Takeda M, et al. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7hypothalamic cells[J]. J Endocrinol,2009,203(1):87.
[34]杨鲁莹,郭兆安,马娉娉.连黄降浊颗粒对自发性高血压大鼠肾组织TGF-β1/smads信号传导通路的影响[J].中国中西医结合肾病杂志,2016,17(7):582.
[35]孙禄,袁迅玲,杨亚琦.大黄素对大鼠肾纤维化肾间质中骨形态发生蛋白-7表达的影响及意义[J].中国临床研究,2017,9(3):73.
[36]李春雨,魏晓露,苏玮莲,等.扶肾降浊方对肾小管间质损害大鼠抗纤维化因子HGF、BMP-7的影响[J].天津中医药,2014,31(12):748.
[37]康洁.血府逐瘀汤对人肾小管上皮细胞CTGF、BMP-7表达的影响[J].医学信息,2014,27(8):109.
[38]张兴坤,司福全,张丽,等.益元软坚法对糖尿病肾病患者血清TGF-β1、BMP-7表达的影响[J].中医研究,2018,31(1):23.
[39]朱斐斐,姚金,刘波,等.泄浊化瘀饮联合氯沙坦治疗早中期慢性肾衰竭疗效及对CTGF、BMP-7的影响[J].中华中医药学刊,2018,36(1):229.
[40]刘琳娜,李李,王蕾,等.三角草治疗肾性骨病的基础研究[J].中国中西医结合肾病杂志,2017,18(6):516.
[41]唐德志,杨洲,笪巍伟,等.不同剂量健腰密骨片对骨形成和小鼠骨髓间充质干细胞中BMP-7表达的影响[J].上海中医药杂志,2016,50(7):72.
[42]杨君,陈剑强,周甜.中医手法松解联合壮骨活血中药促进下肢骨折术后康复的疗效观察[J].中国中医急症,2018,27(3):518.
[43]高嵩,杨光,田书建,等.加味八珍汤在骨折不愈合患者临床治疗中的应用[J].中药药理与临床,2015,31(3):145.
[2] PostlethwaiteAE,RaghowR,StricklinG,etal.Osteogenicprotein-1,a bone morphogenic member of the TGF-beta superfamily,shares chemotactic but not fibrogenic properties with TGF-beta[J]. J Cell Physiol,1994,161(3):562.
[3] Chen P,Vukicevic S,Sampath T K,et al. Osteogenic protein-1promotes growth and maturation of chick sternal chondrocytes in serum-free cultures[J]. J Cell Sci,1995,108(1):105.
[4] Dudley A T,Lyons K M,Robertson E J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye[J]. Genes Dev,1995,9(22):2795.
[5] Tseng Y M, Kokkotou E, Schulz T J, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure[J]. Nature,2008,454:1000.
[6] Kobayashi A, Okuda H, Xing F, et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone[J]. Exp Med,2011,208(13):2641.
[7] Boon M R, van der Horst G, van der Pluijm G, et al. Bone morphogenetic protein 7:a broad spectrum growth factor with multiple target therapeutic potency[J]. Cytokine Growth Factor Rev,2011,22(4):221.
[8] Carreira A C,Lojudice F H,Halcsik E,et al. Bone morphogenetic proteins:facts,challenges,and future prospectives[J]. Dent Res,2014,93(4):335.
[9] Abir R,Ben-Haroush A,Melamed N,et al. Expression of bone morphogenetic proteins 4 and 7 and their receptors IA,IB,and II in human ovaries from fetuses and adults[J]. Fertil Steril,2008,89(5Suppl):1430.
[10] Erickson G F,Shimasaki S. The spatiotemporal expression of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle[J]. Reprod Biol Endocrinol,2003,1:9.
[11] Liu F,Ventura F,Doody J,et al. Human type II receptor for bone morphogenic proteins(BMPs):extension of the twokinase receptor model to the BMPs[J]. Mol Cell Biol,1995,15(7):3479.
[12] Shimizu T, Magata F, Abe Y, et al. Bone morphogenetic protein 4(BMP-4)and BMP-7 induce vascular endothelial growth factor expression in bovine granulosa cells[J]. Anim Sci J,2012,83(9):663.
[13] Chang H M, Qiao J, Leung C K P. Oocyte-somatic cell interactions in the human ovary:novel role of bone morphogenetic proteins and growth differentiation factors[J].Hum Reprod Update,2016,23(1):1.
[14] Lee W S, Otsuka F, Moore R K, et al. Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat[J]. Biol Reprod,2001,65(4):994.
[15] Lee W S, Yoon S J, Yoon T K, et al. Effects of bone morphogenetic protein-7(BMP-7)on primordial follicular growth in the mouse ovary[J]. Mol Reprod Dev,2004,69(2):159.
[16] Zhu G Q, Cui Y H, Wang Q L, et al. Bone morphogenetic proteins(BMP)2, 4, 6 and 7 affect ovarian follicular development through regulation of follicle-stimulating hormone receptor(FSHR)and luteinizing hormone receptor(LHR)expression in goat granulosa cells[J]. J Cell Biol Genetics,2013,3(1):14.
[17] Kayamori T, Kosaka N, Miyamoto A, et al. The differential pathways of bone morphogenetic protein(BMP)-4 and-7 in the suppression of the bovine granulosa[J]. Mol Cell Biochem,2009,323(1):161.
[18] Onagbesan O M, Bruggeman V, Van A P, et al. BMPs and BMPRs in chicken ovary and effects of BMP-4 and-7 on granulosa cell proliferation and progesterone production in vitro[J]. Am J Physiol Endocrinol Metab,2003,285:973.
[19] Shi J,Yoshino O,Osuga Y,et al. Bone morphogenetic protein7(BMP-7)increases the expression of follicle-stimulating hormone(FSH)receptor in human granulosa cells[J]. Fertil Steril,2010,93(4):1273.
[20] Shi J,Yoshino O,Osuga Y,et al. Growth differentiation factor3 is induced by bone morphogenetic protein 6(BMP-6)and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells[J]. Fertil Steril,2012,97(4):979.
[21] Zhang H,Klausen C,Zhu H,et al. BMP4 and BMP7 suppress StAR and progesterone production via ALK3 and SMAD1/5/8-SMAD4 in human granulosa-lutein cells[J]. Endocrinology,2015,156(11):4269.
[22] Juengel J L,Reader K L,Bibby A H,et al. The role of bone morphogenetic proteins 2,4,6 and 7 during ovarian follicular development in sheep:contrast to rat[J]. Reproduction,2006,131(3):501.
[23] Glister C,Kemp C F,Knight P G. Bone morphogenetic protein(BMP)ligands and receptors in bovine ovarian follicle cells:actions of BMP-4,-6, and-7 on granulosa cells and differential modulation of SMAD-1 phosphorylation by follistatin[J]. Reproduction,2004,127(2):239.
[24] Chang H M,Cheng J C,Leung P C. Theca-derived BMP4 and BMP7 down-regulate connexin 43 expression and decrease gap junction intercellular communication activity in immortalized human granulosa cells[J]. J Clin Endocrinol Metab,2013,98(3):E437.
[25] Chang H M,Cheng J C,Klausen C,et al. Recombinant BMP4and BMP7 increase activin A production by up-regulating inhibinβA subunit and furin expression in human granulosalutein cells[J]. J Clin Endocrinol Metab,2015,100(3):E375.
[26] Chang H M,Cheng J C,Fang L L,et al. Recombinant BMP4and BMP7 downregulate pentraxin 3 in human granulosa cells[J]. J Clin Endocrinol Metab,2015,100(3):365.
[27] Sovershaev T A, Unruh D, Sveinbj?rnsson B, et al. A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human monocytic cells[J]. Thromb Res,2016,147:24.
[28] Shimizu T, Jiang J Y, Iijima K, et al. Induction of follicular development by direct single injection of vascular endothelial growth factor gene fragments into the ovary of miniature gilts[J].Biol Reprod,2003,69(4):1388.
[29] Paria B C, Ma W, Tan J, et al. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors[J]. Proc Natl Acad Sci U S A,2001,98(3):1047.
[30] Kodama A, Yoshino O, Osugal Y, et al. Progesterone decreases bone morphogenetic protein(BMP)7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells[J]. Hum Reprod,2010,25(3):751.
[31] Monsivais D,Clementi C,Peng J,et al. BMP7 induces uterine receptivity and blastocyst attachment[J]. Endocrinology,2017,158(4):979.
[32] Takeda M,Otsuka F,Takahashi H,et al. Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and-7 signaling in LβT2 gonadotrope cells[J]. Mol Cell Endocrinol,2012,348(1):147.
[33] Otani H, Otsuka F, Takeda M, et al. Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7hypothalamic cells[J]. J Endocrinol,2009,203(1):87.
[34]杨鲁莹,郭兆安,马娉娉.连黄降浊颗粒对自发性高血压大鼠肾组织TGF-β1/smads信号传导通路的影响[J].中国中西医结合肾病杂志,2016,17(7):582.
[35]孙禄,袁迅玲,杨亚琦.大黄素对大鼠肾纤维化肾间质中骨形态发生蛋白-7表达的影响及意义[J].中国临床研究,2017,9(3):73.
[36]李春雨,魏晓露,苏玮莲,等.扶肾降浊方对肾小管间质损害大鼠抗纤维化因子HGF、BMP-7的影响[J].天津中医药,2014,31(12):748.
[37]康洁.血府逐瘀汤对人肾小管上皮细胞CTGF、BMP-7表达的影响[J].医学信息,2014,27(8):109.
[38]张兴坤,司福全,张丽,等.益元软坚法对糖尿病肾病患者血清TGF-β1、BMP-7表达的影响[J].中医研究,2018,31(1):23.
[39]朱斐斐,姚金,刘波,等.泄浊化瘀饮联合氯沙坦治疗早中期慢性肾衰竭疗效及对CTGF、BMP-7的影响[J].中华中医药学刊,2018,36(1):229.
[40]刘琳娜,李李,王蕾,等.三角草治疗肾性骨病的基础研究[J].中国中西医结合肾病杂志,2017,18(6):516.
[41]唐德志,杨洲,笪巍伟,等.不同剂量健腰密骨片对骨形成和小鼠骨髓间充质干细胞中BMP-7表达的影响[J].上海中医药杂志,2016,50(7):72.
[42]杨君,陈剑强,周甜.中医手法松解联合壮骨活血中药促进下肢骨折术后康复的疗效观察[J].中国中医急症,2018,27(3):518.
[43]高嵩,杨光,田书建,等.加味八珍汤在骨折不愈合患者临床治疗中的应用[J].中药药理与临床,2015,31(3):145.