骨痿安汤联合西药改善类风湿关节炎继发骨质疏松60例临床观察
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摘要
目的:观察骨痿安汤联合西药改善类风湿关节炎继发骨质疏松的临床疗效。方法:将120例类风湿关节炎患者随机分为治疗组和对照组,每组60例。对照组给予来氟米特片、甲氨蝶呤片口服治疗;治疗组在对照组基础上给予骨痿安汤治疗。2组疗程均为6个月。观察2组治疗前后血钙、血清骨源性碱性磷酸酶及骨密度等实验指标的改变情况。结果:治疗后,治疗组血钙及骨密度均较治疗前显著提高(P<0.05),骨源性碱性磷酸酶较治疗前显著下降(P<0.05);2组治疗后比较,差异有统计学意义(P<0.05)。结论:骨痿安汤联合西药可明显改善类风湿关节炎继发骨质疏松患者的骨代谢。
Objective:To observe the effects of Guwei'an Tang(骨痿安汤)combined with western medicine on improving osteoporosis secondary to rheumatoid arthritis.Methods:One hundred and twenty patients with rheumatoid arthritis were randomly divided into a treatment group and a control group,60 cases in each group.The control group was orally given Lefl unomide Tablets and Methotrexate Tablets,while the treatment group was treated with Guwei'an Tang on the basis of the treatment for the control group.The two groups were treated for 6 months.The changes of Ca,BALP and BMD in both groups were observed before and after treatment.Results:After treatment,Ca and BMD were signifi cantly higher in the treatment group than those before the treatment(P < 0.05),and BALP was signifi cantly lower than that before the treatment(P < 0.05).The difference between the two groups was statistically significant(P < 0.05).Conclusion:Guwei'an Tang Combined with western medicine can signifi cantly improve bone metabolism in patients with osteoporosis secondary to rheumatoid arthritis.
Objective:To observe the effects of Guwei'an Tang(骨痿安汤)combined with western medicine on improving osteoporosis secondary to rheumatoid arthritis.Methods:One hundred and twenty patients with rheumatoid arthritis were randomly divided into a treatment group and a control group,60 cases in each group.The control group was orally given Lefl unomide Tablets and Methotrexate Tablets,while the treatment group was treated with Guwei'an Tang on the basis of the treatment for the control group.The two groups were treated for 6 months.The changes of Ca,BALP and BMD in both groups were observed before and after treatment.Results:After treatment,Ca and BMD were signifi cantly higher in the treatment group than those before the treatment(P < 0.05),and BALP was signifi cantly lower than that before the treatment(P < 0.05).The difference between the two groups was statistically significant(P < 0.05).Conclusion:Guwei'an Tang Combined with western medicine can signifi cantly improve bone metabolism in patients with osteoporosis secondary to rheumatoid arthritis.
引文
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[9]蒙海燕,曲晓波,李娜,等.鹿茸及鹿角胶对去卵巢大鼠骨质疏松症的影响[J].中药材,2009,32(2):179.
[2]刘中厚,杨定绰,朱汉民,等.中国人骨质疏松症建议诊断标准(第2稿)[J].中国骨质疏松杂志,2000,6(1):1-3.
[3]陈美玲,周学平.类风湿关节炎继发骨质疏松的中医病机探讨[J].风湿病与关节炎,2013,2(4):42-43.
[4]刘源,郭艳幸,郭珈宜,等.从虚论治骨质疏松症[J].风湿病与关节炎,2016,5(8):67-69.
[5]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:570.
[6]国家药典委员会.《中华人民共和国药典》[M].北京:中国医药科技出版社,2010:759.
[7]徐祥赫,刘钊,王虹,等.杜仲对MC3T3-E1成骨细胞及OPG/RANKL比值的影响[J].天津医科大学学报,2013,19(3):203-205.
[8]徐钢,孙娜,赵敏杰,等.狗脊不同炮制品水煎液抗维甲酸致雄性大鼠骨质疏松症研究[J].中国中药杂志,2014,39(6):1011-1015.
[9]蒙海燕,曲晓波,李娜,等.鹿茸及鹿角胶对去卵巢大鼠骨质疏松症的影响[J].中药材,2009,32(2):179.