摘要
miRNA是一类分子长度为20~24个核苷酸的微小RNA,通常在转录后水平调控靶基因的降解或抑制翻译。趋化因子是具有趋化吸引性的蛋白质,而免疫细胞可以表达不同的趋化因子受体,因此趋化因子能够吸引免疫细胞到达炎症部位,参与自身免疫病的发生和发展。越来越多的证据显示miRNA在自身免疫病中发挥重要作用,文章将对目前已知的miRNA在自身免疫病中对趋化作用的调控的研究进展作一综述。
引文
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