膝骨关节炎的X线特点及临床意义分析
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摘要
目的探讨膝骨关节炎的X线特点及临床意义。方法选择本院2017年6月至2018年6月收治的膝骨关节炎患者76例,所有患者皆行X线检查,并采用酶联免疫吸附试验(ELISA)检测患者关节液中IL-1β、TNF-ɑ及TLR4水平情况,并分析X线分级与临床表现的关系。结果膝骨关节炎X线分级与临床分级呈正相关性(r=0.713,P<0.05);X线分级为Ⅲ～Ⅳ的患者血清IL-1β、TNF-ɑ及TLR4水平明显高于分级Ⅰ～Ⅱ级者(P<0.05)。结论膝骨关节炎临床表现与其X线影像的K/L分级呈正相关性,X线分级越高,IL-1β、TNF-ɑ及TLR4水平越高,IL-1β、TNF-ɑ及TLR4水平越高说明患者的病情越严重。
Objective To investigate the X-ray characteristics and clinical significance of knee osteoarthritis. Methods 76 patients with knee osteoarthritis were treated in our hospital from June 2017 to June 2018. All the patients were examined by X-ray examination. The enzyme linked immunosorbent assay(ELISA) was used to detect the level of IL-1 beta, TNF-ɑ and TLR4 in the patients' joint fluid, and the relationship between X-ray grading and clinical manifestation was analyzed. Results The X-ray classification of knee osteoarthritis was positively correlated with the clinical classification(r=0.713, P<0.05), and the level of serum IL-1 beta, TNF-and TLR4 in the patients with grade III-IV was significantly higher than that of grade I-II(P<0.05). Conclusion The clinical manifestation of osteoarthritis of the knee is positively correlated with the K/L grade of X-ray.The higher the X-ray grade, the higher the level of IL-1 beta, TNF-and TLR4. The higher the level of IL-1, TNF-ɑ, and TLR4, the more serious the patient' s condition is.
Objective To investigate the X-ray characteristics and clinical significance of knee osteoarthritis. Methods 76 patients with knee osteoarthritis were treated in our hospital from June 2017 to June 2018. All the patients were examined by X-ray examination. The enzyme linked immunosorbent assay(ELISA) was used to detect the level of IL-1 beta, TNF-ɑ and TLR4 in the patients' joint fluid, and the relationship between X-ray grading and clinical manifestation was analyzed. Results The X-ray classification of knee osteoarthritis was positively correlated with the clinical classification(r=0.713, P<0.05), and the level of serum IL-1 beta, TNF-and TLR4 in the patients with grade III-IV was significantly higher than that of grade I-II(P<0.05). Conclusion The clinical manifestation of osteoarthritis of the knee is positively correlated with the K/L grade of X-ray.The higher the X-ray grade, the higher the level of IL-1 beta, TNF-and TLR4. The higher the level of IL-1, TNF-ɑ, and TLR4, the more serious the patient' s condition is.
引文
[1]吴火生,龚国华,谢明玉.氨基葡萄糖联合玻璃酸钠对膝骨关节炎的治疗作用[J].当代医学,2017,23(17):46-48.
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[6]陈俊杰,庄汝杰,范续,等.膝骨关节炎软骨下炎症面积与关节液中白细胞介素-1含量的相关性研究[J].中医正骨,2016,28(4):9-11.
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[9]李明超,肖睿,李伟,等.血清和关节液HMGB1水平与膝骨关节炎严重程度的相关性研究[J].重庆医科大学学报,2017,42(5):570-574.
[10]李志昌,姜龙,张舒,等.终末期骨关节炎患者全膝关节置换术前的躯体功能客观测定[J].北京大学学报(医学版),2016,48(2):257-262.
[11]刘琳琳,傅捷,张树明,等.IL-6联合MMP-3在早期诊断骨性关节炎中表达及临床意义[J].中国实验诊断学,2017,21(2):273-276.
[12]谢平金,柴生颋.膝骨性关节炎X线片观测指标及其应用进展[J].中国中医骨伤科杂志,2017,25(3):72-76.
[13]王善超,孙卫平,王海波,等.复方丹参注射液联合玻璃酸钠关节腔内给药对骨性膝关节炎患者炎症反应及膝关节功能的影响[J].中国生化药物杂志,2017,37(2):100-102.
[2]文毅英,潘伟,杨慧文,等.关节镜下膝外侧支持带松解加关节清理术在老年膝关节骨性关节炎的临床应用[J].当代医学,2016,22(16):22-23.
[3]Karsdal MA,Bay-Jensen AC,Henriksen K,et al.Rheumatoid arthritis:a case for personalized health care?[J].Arthritis Care&Research,2014,66(9):1273-1280.
[4]马晶,鄂晓强.康复护理干预在膝骨关节炎患者行膝关节功能锻炼期间的应用[J].中国医药导报,2016,13(30):150-152.
[5]杨剑标.独活寄生汤治疗膝关节骨性关节炎临床疗效及对膝关节液炎症因子的影响[J].河北中医,2016,38(8):1202-1205.
[6]陈俊杰,庄汝杰,范续,等.膝骨关节炎软骨下炎症面积与关节液中白细胞介素-1含量的相关性研究[J].中医正骨,2016,28(4):9-11.
[7]张栋,王庆甫,石鑫超,等.膝骨关节炎肌骨超声与X线片表现的比较与分析[J].中国骨伤,2016,29(5):429-433.
[8]沈学强,姜宏.中药熏洗治疗膝骨关节炎的临床与实验研究进展[J].国际中医中药杂志,2017,39(4):380-382.
[9]李明超,肖睿,李伟,等.血清和关节液HMGB1水平与膝骨关节炎严重程度的相关性研究[J].重庆医科大学学报,2017,42(5):570-574.
[10]李志昌,姜龙,张舒,等.终末期骨关节炎患者全膝关节置换术前的躯体功能客观测定[J].北京大学学报(医学版),2016,48(2):257-262.
[11]刘琳琳,傅捷,张树明,等.IL-6联合MMP-3在早期诊断骨性关节炎中表达及临床意义[J].中国实验诊断学,2017,21(2):273-276.
[12]谢平金,柴生颋.膝骨性关节炎X线片观测指标及其应用进展[J].中国中医骨伤科杂志,2017,25(3):72-76.
[13]王善超,孙卫平,王海波,等.复方丹参注射液联合玻璃酸钠关节腔内给药对骨性膝关节炎患者炎症反应及膝关节功能的影响[J].中国生化药物杂志,2017,37(2):100-102.