葡萄酒与健康关系的研究新进展
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摘要
大量流行病学和实验室研究表明,适量的饮用葡萄酒可有效预防和减少心脑血管疾病、癌症、炎症、认知功能障碍等的发生,同时,对骨质也具有一定程度的保护作用,这些功效与葡萄酒中的多酚类化合物关系密切。近年来,葡萄酒中的生物活性成分与肠道微生物之间的相互作用也受到了广泛关注。该文就葡萄酒与人体健康关系的研究现状进行了回顾,以期为更深入的了解葡萄酒提供参考依据。
A large number of epidemiological and experimental studies have showed that moderate consumption of wine could effectively prevent and reduce the risk of cardiovascular and cerebrovascular diseases, some types of cancer, inflammation, cognitive dysfunction, etc. Meanwhile, it can protect bone to some extent. The polyphenol compounds in wine play the most important role to these health effects. In recent years, the interaction between bioactive components in wine and intestinal microbes has also attracted more and more attention. In this paper, the research status of the relationship between wine and human health were reviewed to provide more reference for people to understand wine more deeply.
A large number of epidemiological and experimental studies have showed that moderate consumption of wine could effectively prevent and reduce the risk of cardiovascular and cerebrovascular diseases, some types of cancer, inflammation, cognitive dysfunction, etc. Meanwhile, it can protect bone to some extent. The polyphenol compounds in wine play the most important role to these health effects. In recent years, the interaction between bioactive components in wine and intestinal microbes has also attracted more and more attention. In this paper, the research status of the relationship between wine and human health were reviewed to provide more reference for people to understand wine more deeply.
引文
[1]关棣锴,聂继云,李志霞,等.葡萄及其制品营养与功能的研究进展[J].保鲜与加工,2017,17(12):142-146.
[2]CUERVO A,DE LOS REYES-GAVILAN C G,RUAS-MADIEDO P,et al.Red wine consumption is associated with fecal microbiota and malondialdehyde in a human population[J].J Am College Nutr,2015,34(2):135-141.
[3]DUDA-CHODAK A,TARKO T,SATORA P,et al.Interaction of dietary compounds,especially polyphenols,with the intestinal microbiota:a review[J].Eur J Nutr,2015,54(3):325-341.
[4]FAIRWEATHER-TAIT S J,SKINNER J,GUILE G R,et al.Diet and bone mineral density study in postmenopausal women from the Twins UKregistry shows a negative association with a traditional English dietary pattern and a positive association with wine[J].Am J Clin Nutr,2011,94(5):1371-1375.
[5]DEL PINO-GARCIA R,RIVERO-PEREZ M D,GONZALEZ-SANJOSEM L,et al.Chemopreventive potential of powdered red wine pomace seasonings against colorectal cancer in HT-29 Cells[J].J Agric Food Chem,2017,65(1):1-30.
[6]WOOD A M,KAPTOGE S,BUTTERWORTH A,et al.Risk thresholds for alcohol consumption:combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies[J].Lancet,2018,391(10129):1513-1523.
[7]侯丽娟,马艳莉,夏亚男,等.HPLC检测葡萄酒中12种单体酚的方法研究[J].食品工业,2016,37(4):202-206.
[8]杜彬,任艳军,杨林华,等.不同产区葡萄酒中氨基酸和微量元素的测定分析[J].食品工业,2011,32(8):108-110.
[9]罗晓雷,刘霞.认知葡萄酒[J].食品工程,2014(1):15-17.
[10]王晨,房经贵,刘洪,等.葡萄与葡萄酒的营养成分[J].江苏林业科技,2009,36(4):38-40.
[11]FERNANDES I,PEREZ-GREGORIO R,SOARES S,et al.Wine flavonoids in health and disease prevention[J].Molecules,2017,22(2):1-30.
[12]CHIVA-BLANCH G,ARRANZ S,LAMUELA-RAVENTOS R M,et al.Effects of wine,alcohol and polyphenols on cardiovascular disease risk factors:evidences from human studies[J].Alcohol Alcoholism,2013,48(3):270-277.
[13]GUILFORD J M,PEZZUTO J M.Wine and health:a review[J].Am JEnol Viticult,2011,62(4):471-486.
[14]JURCEVIC I L,DORA M,GUBEROVIC I,et al.Polyphenols from wine lees as a novel functional bioactive compound in the protection against oxidative stress and hyperlipidaemia[J].Food Technol Biotechnol,2017,55(1):109-116.
[15]KHAN N Q,PATEL B,KANG S S,et al.Regulation of vascular endothelial function by red wine procyanidins:implications for cardiovascular health[J].Tetrahedron,2015,71(20):3059-3065.
[16]ARGYROU C,VLACHOGIANNI I,STAMATAKIS G,et al.Postprandial effects of wine consumption on platelet activating factor metabolic enzymes[J].Prostagland Lipid Mediat,2017,130(23):23-29.
[17]XANTHOPOULOU M N,KALATHARA K,MELACHROINOU S,et al.Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men[J].Eur J Nutr,2017,56(4):1485-1492.
[18]TENTA R,FRAGOPOULOU E,TSOUKALA M,et al.Antiproliferative effects of red and white wine extracts in PC-3 prostate cancer cells[J].Nutr Cancer Int J,2017,69(6):952-961.
[19]BESSAOUD F,DAURES J P.Patterns of alcohol(especially wine)consumption and breast cancer risk:A case-control study among a population in Southern France[J].Ann Epidemiol,2008,18(6):467-475.
[20]CARDOSO L M D,PIMENTA N D A,FIOCHI R D F,et al.Effects of red wine,grape juice and resveratrol consumption on bone parameters of Wistar rats submitted to high-fat diet and physical training[J].Nutr Hospital,2018,35(2):416-420.
[21]宋雪琳,李雅梅,肖俊松,等.葡萄籽原花青素对营养肥胖模型大鼠肠道菌群的影响[J].食品科学技术学报,2015,33(5):39-46.
[22]MENDES D,OLIVEIRA M M,MOREIRA P I,et al.Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology[J].J Nutr Biochem,2018,55:165-177.
[23]XIA X Y,SUN B S,LI W,et al.Anti-diabetic activity phenolic constituents from red wine against alpha-glucosidase and alpha-amylase[J].J Food Process Preservat,2017,41(3):1-5.
[24]FAGHERAZZI G,VILIER A,LAJOUS M,et al.Wine consumption throughout life is inversely associated with type 2 diabetes risk,but only in overweight individuals:results from a large female French cohort study[J].Eur J Epidemiol,2014,29(11):831-839.
[25]黄沛力,李建新,张淑华,等.银杏叶不同有效成分抑制金属离子诱导人血浆低密度脂蛋白氧化修饰的比较研究[J].中药材,2004,27(9):654-656.
[26]田玲,徐志敏,王华.红葡萄酒对胆固醇氧化的抑制作用[J].西北农林科技大学学报:自然科学版,2011,39(12):181-185.
[27]王宏宇,胡大一.血管内皮功能检测的临床应用[J].中国医刊,2003,38(3):58-60.
[28]王志荣.白藜三醇及国产红葡萄酒抗动脉粥样硬化作用的实验研究[D].南京:南京医科大学,2002.
[29]VAUZOUR D,HOUSEMAN E J,GEORGE T W,et al.Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers[J].Brit J Nutr,2010,103(8):1168-1178.
[30]WALLERATH T,DECKERT G,TERNES T,et al.Resveratrol,a polyphenolic phytoalexin present in red wine,enhances expression and activity of endothelial nitric oxide synthase[J].J Ame Heart Associat,2002,106(13):1652-1658.
[31]李超,姜枫,李运伦.氧化应激和自噬在动脉粥样硬化中的作用[J].重庆医学,2017(35):5020-5022.
[32]COOPER K A,CHOPRA M,THURNHAM D I.Wine polyphenols and promotion of cardiac health[J].Nutr Res Rev,2004,17(1):111-130.
[33]陈熤,李剑,施海明.血小板致动脉粥样硬化斑块形成的相关研究[J].国际心血管病杂志,2010,37(6):357-360.
[34]夏良.白藜芦醇对外周血内皮祖细胞的影响及其机制研究[D].杭州:浙江大学,2009.
[35]毛拥军,王珍,林淑美,等.适量饮酒对健康成年男性血浆TXB_2,6-Keto-PGF_(2a)及血小板聚集功能的影响[J].齐鲁医学杂志,2002,17(3):205-207.
[36]GABRIELA A-M,GIULIANA N,SUSANNE M T.Red wine polyphenolics reduce the expression of inflammation markers in human colonderived CCD-18Co myofibroblast cells:Potential role of micro RNA-126[J].Food Funct,2012,3(7):745-752.
[37]GOCMEZ S S,GACAR N,UTKAN T,et al.Protective effects of resveratrol on aging-induced cognitive impairment in rats[J].Neurobiol Learn Memory,2016,131(Suppl 2):131-136.
[38]SHAN H,CUIRONG S,YUANJIANG P.Red wine polyphenols for cancer prevention[J].Int J Mol Sci,2009,9(5):842-853.
[39]陈丽琼.葡萄酒贮藏期间主要理化指标和抗氧化活性的动态变化研究[D].兰州:兰州理工大学,2016.
[40]CHANDRAMOHAN REDDY T,BHARAT REDDY D,APARNA A,et al.Anti-leukemic effects of gallic acid on human leukemia K562 cells:Downregulation of COX-2,inhibition of BCR/ABL kinase and NF-κBinactivation[J].Toxicol in Vitro,2012,26(3):396-405.
[41]DE NICOL魹S,CARITO V,FIORE M,et al.Aberrant behavioral and neurobiologic profiles in rodents exposed to ethanol or red wine early in development[J].Curr Developm Disord Report,2014,1(3):173-180.
[42]MARIO C,RUBEN C,NEVILLE V.Putative role of red wine polyphenols against brain pathology in Alzheimer's and parkinson's disease[J].Front Nutr,2016,3(31):1-16.
[43]ABDELKADER B,ST魪PHANIE S,NASSIMA C,et al.Wine polyphenols:potential agents in neuroprotection[J].Oxidat Med Cell Long,2012,2012(2):1-14.
[44]LI Z N,WANG Z X,MENG G,et al.Identification of an ene reductase from yeast Kluyveromyces marxianus and application in the asymmetric synthesis of(R)-profen esters[J].Asian J Organ Chem,2018,7(4):763-769.
[45]PATEL A K,ROGERS J T,HUANG X D.Flavanols,mild cognitive impairment,and Alzheimer's dementia[J].Int J Clin Exp Med,2008,1(2):181-191.
[46]CUEVA C,GIL-SANCHEZ I,AYUDA-DURAN B,et al.An integrated view of the effects of wine polyphenols and their relevant metabolites on gut and host health[J].Molecules,2017,22(1):1-15.
[47]QUEIPO-ORTUNO M I,BOTO-ORDONEZ M,MURRI M,et al.Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers[J].Am J Clin Nutr,2012,95(6):1323-1334.
[2]CUERVO A,DE LOS REYES-GAVILAN C G,RUAS-MADIEDO P,et al.Red wine consumption is associated with fecal microbiota and malondialdehyde in a human population[J].J Am College Nutr,2015,34(2):135-141.
[3]DUDA-CHODAK A,TARKO T,SATORA P,et al.Interaction of dietary compounds,especially polyphenols,with the intestinal microbiota:a review[J].Eur J Nutr,2015,54(3):325-341.
[4]FAIRWEATHER-TAIT S J,SKINNER J,GUILE G R,et al.Diet and bone mineral density study in postmenopausal women from the Twins UKregistry shows a negative association with a traditional English dietary pattern and a positive association with wine[J].Am J Clin Nutr,2011,94(5):1371-1375.
[5]DEL PINO-GARCIA R,RIVERO-PEREZ M D,GONZALEZ-SANJOSEM L,et al.Chemopreventive potential of powdered red wine pomace seasonings against colorectal cancer in HT-29 Cells[J].J Agric Food Chem,2017,65(1):1-30.
[6]WOOD A M,KAPTOGE S,BUTTERWORTH A,et al.Risk thresholds for alcohol consumption:combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies[J].Lancet,2018,391(10129):1513-1523.
[7]侯丽娟,马艳莉,夏亚男,等.HPLC检测葡萄酒中12种单体酚的方法研究[J].食品工业,2016,37(4):202-206.
[8]杜彬,任艳军,杨林华,等.不同产区葡萄酒中氨基酸和微量元素的测定分析[J].食品工业,2011,32(8):108-110.
[9]罗晓雷,刘霞.认知葡萄酒[J].食品工程,2014(1):15-17.
[10]王晨,房经贵,刘洪,等.葡萄与葡萄酒的营养成分[J].江苏林业科技,2009,36(4):38-40.
[11]FERNANDES I,PEREZ-GREGORIO R,SOARES S,et al.Wine flavonoids in health and disease prevention[J].Molecules,2017,22(2):1-30.
[12]CHIVA-BLANCH G,ARRANZ S,LAMUELA-RAVENTOS R M,et al.Effects of wine,alcohol and polyphenols on cardiovascular disease risk factors:evidences from human studies[J].Alcohol Alcoholism,2013,48(3):270-277.
[13]GUILFORD J M,PEZZUTO J M.Wine and health:a review[J].Am JEnol Viticult,2011,62(4):471-486.
[14]JURCEVIC I L,DORA M,GUBEROVIC I,et al.Polyphenols from wine lees as a novel functional bioactive compound in the protection against oxidative stress and hyperlipidaemia[J].Food Technol Biotechnol,2017,55(1):109-116.
[15]KHAN N Q,PATEL B,KANG S S,et al.Regulation of vascular endothelial function by red wine procyanidins:implications for cardiovascular health[J].Tetrahedron,2015,71(20):3059-3065.
[16]ARGYROU C,VLACHOGIANNI I,STAMATAKIS G,et al.Postprandial effects of wine consumption on platelet activating factor metabolic enzymes[J].Prostagland Lipid Mediat,2017,130(23):23-29.
[17]XANTHOPOULOU M N,KALATHARA K,MELACHROINOU S,et al.Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men[J].Eur J Nutr,2017,56(4):1485-1492.
[18]TENTA R,FRAGOPOULOU E,TSOUKALA M,et al.Antiproliferative effects of red and white wine extracts in PC-3 prostate cancer cells[J].Nutr Cancer Int J,2017,69(6):952-961.
[19]BESSAOUD F,DAURES J P.Patterns of alcohol(especially wine)consumption and breast cancer risk:A case-control study among a population in Southern France[J].Ann Epidemiol,2008,18(6):467-475.
[20]CARDOSO L M D,PIMENTA N D A,FIOCHI R D F,et al.Effects of red wine,grape juice and resveratrol consumption on bone parameters of Wistar rats submitted to high-fat diet and physical training[J].Nutr Hospital,2018,35(2):416-420.
[21]宋雪琳,李雅梅,肖俊松,等.葡萄籽原花青素对营养肥胖模型大鼠肠道菌群的影响[J].食品科学技术学报,2015,33(5):39-46.
[22]MENDES D,OLIVEIRA M M,MOREIRA P I,et al.Beneficial effects of white wine polyphenols-enriched diet on Alzheimer's disease-like pathology[J].J Nutr Biochem,2018,55:165-177.
[23]XIA X Y,SUN B S,LI W,et al.Anti-diabetic activity phenolic constituents from red wine against alpha-glucosidase and alpha-amylase[J].J Food Process Preservat,2017,41(3):1-5.
[24]FAGHERAZZI G,VILIER A,LAJOUS M,et al.Wine consumption throughout life is inversely associated with type 2 diabetes risk,but only in overweight individuals:results from a large female French cohort study[J].Eur J Epidemiol,2014,29(11):831-839.
[25]黄沛力,李建新,张淑华,等.银杏叶不同有效成分抑制金属离子诱导人血浆低密度脂蛋白氧化修饰的比较研究[J].中药材,2004,27(9):654-656.
[26]田玲,徐志敏,王华.红葡萄酒对胆固醇氧化的抑制作用[J].西北农林科技大学学报:自然科学版,2011,39(12):181-185.
[27]王宏宇,胡大一.血管内皮功能检测的临床应用[J].中国医刊,2003,38(3):58-60.
[28]王志荣.白藜三醇及国产红葡萄酒抗动脉粥样硬化作用的实验研究[D].南京:南京医科大学,2002.
[29]VAUZOUR D,HOUSEMAN E J,GEORGE T W,et al.Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers[J].Brit J Nutr,2010,103(8):1168-1178.
[30]WALLERATH T,DECKERT G,TERNES T,et al.Resveratrol,a polyphenolic phytoalexin present in red wine,enhances expression and activity of endothelial nitric oxide synthase[J].J Ame Heart Associat,2002,106(13):1652-1658.
[31]李超,姜枫,李运伦.氧化应激和自噬在动脉粥样硬化中的作用[J].重庆医学,2017(35):5020-5022.
[32]COOPER K A,CHOPRA M,THURNHAM D I.Wine polyphenols and promotion of cardiac health[J].Nutr Res Rev,2004,17(1):111-130.
[33]陈熤,李剑,施海明.血小板致动脉粥样硬化斑块形成的相关研究[J].国际心血管病杂志,2010,37(6):357-360.
[34]夏良.白藜芦醇对外周血内皮祖细胞的影响及其机制研究[D].杭州:浙江大学,2009.
[35]毛拥军,王珍,林淑美,等.适量饮酒对健康成年男性血浆TXB_2,6-Keto-PGF_(2a)及血小板聚集功能的影响[J].齐鲁医学杂志,2002,17(3):205-207.
[36]GABRIELA A-M,GIULIANA N,SUSANNE M T.Red wine polyphenolics reduce the expression of inflammation markers in human colonderived CCD-18Co myofibroblast cells:Potential role of micro RNA-126[J].Food Funct,2012,3(7):745-752.
[37]GOCMEZ S S,GACAR N,UTKAN T,et al.Protective effects of resveratrol on aging-induced cognitive impairment in rats[J].Neurobiol Learn Memory,2016,131(Suppl 2):131-136.
[38]SHAN H,CUIRONG S,YUANJIANG P.Red wine polyphenols for cancer prevention[J].Int J Mol Sci,2009,9(5):842-853.
[39]陈丽琼.葡萄酒贮藏期间主要理化指标和抗氧化活性的动态变化研究[D].兰州:兰州理工大学,2016.
[40]CHANDRAMOHAN REDDY T,BHARAT REDDY D,APARNA A,et al.Anti-leukemic effects of gallic acid on human leukemia K562 cells:Downregulation of COX-2,inhibition of BCR/ABL kinase and NF-κBinactivation[J].Toxicol in Vitro,2012,26(3):396-405.
[41]DE NICOL魹S,CARITO V,FIORE M,et al.Aberrant behavioral and neurobiologic profiles in rodents exposed to ethanol or red wine early in development[J].Curr Developm Disord Report,2014,1(3):173-180.
[42]MARIO C,RUBEN C,NEVILLE V.Putative role of red wine polyphenols against brain pathology in Alzheimer's and parkinson's disease[J].Front Nutr,2016,3(31):1-16.
[43]ABDELKADER B,ST魪PHANIE S,NASSIMA C,et al.Wine polyphenols:potential agents in neuroprotection[J].Oxidat Med Cell Long,2012,2012(2):1-14.
[44]LI Z N,WANG Z X,MENG G,et al.Identification of an ene reductase from yeast Kluyveromyces marxianus and application in the asymmetric synthesis of(R)-profen esters[J].Asian J Organ Chem,2018,7(4):763-769.
[45]PATEL A K,ROGERS J T,HUANG X D.Flavanols,mild cognitive impairment,and Alzheimer's dementia[J].Int J Clin Exp Med,2008,1(2):181-191.
[46]CUEVA C,GIL-SANCHEZ I,AYUDA-DURAN B,et al.An integrated view of the effects of wine polyphenols and their relevant metabolites on gut and host health[J].Molecules,2017,22(1):1-15.
[47]QUEIPO-ORTUNO M I,BOTO-ORDONEZ M,MURRI M,et al.Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers[J].Am J Clin Nutr,2012,95(6):1323-1334.