胚宝胶囊联合激素治疗围绝经期综合征肾阳虚证临床研究
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摘要
目的:观察胚宝胶囊联合激素治疗围绝经期综合征(MPS)肾阳虚证的疗效。方法:筛选本院收治的126例MPS肾阳虚证患者,按随机数字表法分为对照组和治疗组各63例。对照组予替勃龙片治疗,治疗组以胚宝胶囊联合替勃龙片治疗。治疗前后评定2组患者的Kupperman (KI)量表评分、匹兹堡失眠质量指数(PSQI)、汉密尔顿抑郁量表(HAMD)评分、肾阳虚证评分和围绝经期生存质量量表(MENQOL)评分,比较2组的疗效。结果:经Ridit分析,治疗组疾病疗效和中医证候疗效均优于对照组(P <0.05)。2组KI量表评分、肾阳虚证评分、HAMD评分和PSQI评分均较治疗前下降(P <0.01);治疗组4项评分均低于对照组(P <0.01)。2组MENQOL血管舒缩症状、生理状态、心理状态和性生活4个维度的评分均较治疗前下降(P <0.01);治疗组4个维度的评分均低于对照组(P <0.01)。结论:胚宝胶囊联合激素治疗可有效缓解MPS肾阳虚证患者的临床症状,减轻抑郁程度,改善睡眠质量,提高生活质量,临床疗效优于单纯予激素治疗。
Objective:To observe the clinical effect of Peibao capsules combined with hormone for menopausal syndrome(MPS) with kidney-yang deficiency syndrome. Methods:A total of 126 cases of MPS patients with kidney-yang deficiency syndrome admitted into our hospital were divided into the control group and the treatment group according to the random number table method,with 63 cases in each group. The control group was treated with Tibolong tablets and the treatment group received Peibao capsules combined with Tibolong tablets for treatment. Before and after treatment, scores of Kupperman scale(KI),Pittsburgh Insomnia Quality Index(PSQI),Hamilton Depression Scale(HAMD),kidney-yang deficiency syndrome and Menopause-specific Quality of Life Questionnaire(MENQOL) in the two groups were assessed,and the therapeutic effect in the two groups was compared. Results:According to Ridit analysis,the curative effect of diseases and Chinese medicine syndromes in the treatment group was superior to that in the control group(P < 0.05). Scores of KI,kidney-yang deficiency syndrome,HAMD and PSQI in the two groups were decreased when compared with those before treatment(P < 0.01);the above four scores in the treatment group were lower than those in the control group(P < 0.01). The scores of 4 dimensions in MENQOL including vasomotor symptoms,physiological state,psychological state and sex life in both groups were decreased when compared with those before treatment(P < 0.01);the above four scores in the treatment group were lower than those in the control group(P < 0.01). Conclusion:The therapy of Peibao capsules combined with hormone can alleviate the clinical symptoms of MPS patients with kidney-yang deficiency syndrome,alleviate depression,improve quality of sleep and quality of life,whose clinical effect is better than simple hormone therapy.
Objective:To observe the clinical effect of Peibao capsules combined with hormone for menopausal syndrome(MPS) with kidney-yang deficiency syndrome. Methods:A total of 126 cases of MPS patients with kidney-yang deficiency syndrome admitted into our hospital were divided into the control group and the treatment group according to the random number table method,with 63 cases in each group. The control group was treated with Tibolong tablets and the treatment group received Peibao capsules combined with Tibolong tablets for treatment. Before and after treatment, scores of Kupperman scale(KI),Pittsburgh Insomnia Quality Index(PSQI),Hamilton Depression Scale(HAMD),kidney-yang deficiency syndrome and Menopause-specific Quality of Life Questionnaire(MENQOL) in the two groups were assessed,and the therapeutic effect in the two groups was compared. Results:According to Ridit analysis,the curative effect of diseases and Chinese medicine syndromes in the treatment group was superior to that in the control group(P < 0.05). Scores of KI,kidney-yang deficiency syndrome,HAMD and PSQI in the two groups were decreased when compared with those before treatment(P < 0.01);the above four scores in the treatment group were lower than those in the control group(P < 0.01). The scores of 4 dimensions in MENQOL including vasomotor symptoms,physiological state,psychological state and sex life in both groups were decreased when compared with those before treatment(P < 0.01);the above four scores in the treatment group were lower than those in the control group(P < 0.01). Conclusion:The therapy of Peibao capsules combined with hormone can alleviate the clinical symptoms of MPS patients with kidney-yang deficiency syndrome,alleviate depression,improve quality of sleep and quality of life,whose clinical effect is better than simple hormone therapy.
引文
[1]马璇,蒋丽,杨燕芬,等.地贞颗粒对围绝经期综合征患者(阴虚内热证)神经-内分泌的影响[J].中国实验方剂学杂志,2018,24(12):141-146.
[2]马堃,陈燕霞.中西医治疗围绝经期综合征策略的探讨[J].中国中药杂志,2015,40(20):3899-3906.
[3]魏珍珍,苗明三.补肾阳中药治疗围绝经期综合征特点分析[J].中医学报,2013,28(11):1688-1691.
[4]郑斐,冯利平.胚宝胶囊治疗妇女肾阳虚证的临床疗效观察[J].中国中药杂志,2008,33(10):1204-1205.
[5]中华医学会精神科分会.CCMD-3中国精神障碍分类方案与诊断标准[M].3版.济南:山东科学技术出版社,2001:103-104.
[6]中华医学会.临床诊疗指南·妇产科学分册[M].北京:人民卫生出版社,2011:124-127.
[7]中华中医药学会.中医妇科常见病诊疗指南[M].北京:中国中医药出版社,2012:41-43.
[8]路桃影,李艳,夏萍,等.匹兹堡睡眠质量指数的信度及效度分析[J].重庆医学,2014,43(3):260-263.
[9]杨洪艳,成芳平,王小云,等.绝经期生存质量量表中文版本的临床应用与评价[J].中华流行病学杂志,2005,26(1):50-53.
[10]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[11]杨兰,刘保庚,张培浩,等.调冲解郁汤治疗围绝经期抑郁症60例临床观察[J].中国实验方剂学杂志,2015,21(12):182-185.
[12]叶香,陈燕,翟宇,等.围绝经期综合征患者抑郁焦虑症状的研究及其与脑源性神经营养因子的关系[J].中国妇幼保健,2015,30(3):397-398.
[13]谭雪菊,李炜弘,曾跃琴,等.从肾虚病机探讨围绝经期综合征的养护[J].时珍国医国药,2013,24(9):2212-2213.
[14]陈怡,金蕴,虞和永.胚宝胶囊治疗肾阳虚症的临床研究[J].中国现代应用药学杂志,2008,25(8):690-691,698.
[15]王华,王国华.胚宝胶囊治疗女性更年期综合征肾阳虚证多中心临床研究[J].湖南中医药大学学报,2013,33(9):67-69.
[2]马堃,陈燕霞.中西医治疗围绝经期综合征策略的探讨[J].中国中药杂志,2015,40(20):3899-3906.
[3]魏珍珍,苗明三.补肾阳中药治疗围绝经期综合征特点分析[J].中医学报,2013,28(11):1688-1691.
[4]郑斐,冯利平.胚宝胶囊治疗妇女肾阳虚证的临床疗效观察[J].中国中药杂志,2008,33(10):1204-1205.
[5]中华医学会精神科分会.CCMD-3中国精神障碍分类方案与诊断标准[M].3版.济南:山东科学技术出版社,2001:103-104.
[6]中华医学会.临床诊疗指南·妇产科学分册[M].北京:人民卫生出版社,2011:124-127.
[7]中华中医药学会.中医妇科常见病诊疗指南[M].北京:中国中医药出版社,2012:41-43.
[8]路桃影,李艳,夏萍,等.匹兹堡睡眠质量指数的信度及效度分析[J].重庆医学,2014,43(3):260-263.
[9]杨洪艳,成芳平,王小云,等.绝经期生存质量量表中文版本的临床应用与评价[J].中华流行病学杂志,2005,26(1):50-53.
[10]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[11]杨兰,刘保庚,张培浩,等.调冲解郁汤治疗围绝经期抑郁症60例临床观察[J].中国实验方剂学杂志,2015,21(12):182-185.
[12]叶香,陈燕,翟宇,等.围绝经期综合征患者抑郁焦虑症状的研究及其与脑源性神经营养因子的关系[J].中国妇幼保健,2015,30(3):397-398.
[13]谭雪菊,李炜弘,曾跃琴,等.从肾虚病机探讨围绝经期综合征的养护[J].时珍国医国药,2013,24(9):2212-2213.
[14]陈怡,金蕴,虞和永.胚宝胶囊治疗肾阳虚症的临床研究[J].中国现代应用药学杂志,2008,25(8):690-691,698.
[15]王华,王国华.胚宝胶囊治疗女性更年期综合征肾阳虚证多中心临床研究[J].湖南中医药大学学报,2013,33(9):67-69.