四黄软膏外敷缓解鼠神经生长因子注射疼痛的效果观察
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摘要
目的探讨四黄软膏外敷对缓解鼠神经生长因子肌肉注射疼痛的效果观察。方法选取2017年11月1日—2018年11月1日收治使用鼠神经生长因子臀部肌肉注射治疗的骨折患者60例,随机分为对照组和观察组,各30例。对照组行常规疼痛干预,观察组在对照组基础上于注射部位外敷四黄软膏外敷干预。比较2组干预前后疼痛程度。结果干预1周后,2组疼痛均有所缓解,观察组视觉模拟评分法(VAS)评分(2.40±0.33)分,低于对照组(3.20±0.40)分,差异有统计学意义(P<0.05)。结论四黄软膏外敷能有效缓解鼠神经生长因子肌肉注射后产生的疼痛,且操作简便,易于施行。
Objective To investigate the effect of external application of Sihuang ointment on pain caused by injection of mouse nerve growth factor. Methods Totally 60 patients with intramuscular injection of mouse nerve growth factor(NGF) for bone healing after fracture were randomly divided into the control group and the observation group, with 30 cases in each group. Patients of both two groups received care on pain caused by injection, and those in the observation group were given external application of Sihuang ointment at the injection site. The pain degree was evaluated by Visual Analogue Scale(VAS). Results One week after intervention, the VAS score in the observation group was(2.40±0.33), which was lower than(3.20±0.40) in the control group, with a significant difference(P<0.05). Conclusion The external application of Sihuang ointment is effective to relieve the pain caused by injection of NGF.
Objective To investigate the effect of external application of Sihuang ointment on pain caused by injection of mouse nerve growth factor. Methods Totally 60 patients with intramuscular injection of mouse nerve growth factor(NGF) for bone healing after fracture were randomly divided into the control group and the observation group, with 30 cases in each group. Patients of both two groups received care on pain caused by injection, and those in the observation group were given external application of Sihuang ointment at the injection site. The pain degree was evaluated by Visual Analogue Scale(VAS). Results One week after intervention, the VAS score in the observation group was(2.40±0.33), which was lower than(3.20±0.40) in the control group, with a significant difference(P<0.05). Conclusion The external application of Sihuang ointment is effective to relieve the pain caused by injection of NGF.
引文
[1] LUIGI ALOE, MARIA LUISA ROCCO, BIJORN OMAR BALZAMINO, et al. Nerve Growth Factor: A Focus on Neuroscience and Therapy[J]. Curr Neuropharmacol, 2015, 13(3): 294-303.
[2] XI-GUANG SANG, ZHI-YONG WANG, LIN CHENG, et al. Analysis of the mechanism by which nerve growth factor promotes callus formation in mice with tibial fracture[J]. Exp Ther Med. 2017, 13(4): 1376-1380.
[3] 张丽霞, 张凡, 卢锦森. “品管圈”活动减轻脊柱骨科肌肉注射鼠神经生长因子疼痛的疗效评价[J]. 护理研究, 2015, 29(2A): 464-466.
[4] 张开放, 郭忠卫, 宋焕瑾. 鼠神经生长因子对腰椎间盘突出患者术后神经恢复的作用[J]. 中国康复理论与实践, 2012, 18(1): 84-86.
[5] 郑兰飞, 周宝灵, 程卫珍, 等. 硫酸镁湿敷联合艾盐包温灸预防鼠神经生长因子肌肉注射后硬结与疼痛的疗效观察[J]. 护士进修杂志, 2018, 33(5): 441-443.
[6] DERBY R, SEO K S, KAZALA K, et al. A factor analysis of lumbar intradiscal electrothermal annuloplasty outcomes[J]. Spine J, 2005, 5(3): 256-261.
[7] 刘宇涛, 黄潮桐, 陈隆福, 等. 鼠神经生长因子治疗胫骨骨不连效果的实验研究[J]. 中国临床解剖学杂志, 2016, 34(3): 326-330.
[8] JEHAN F, NAVEILHAN P, NEVEU I, et al. Regulation of NGF, BDNF and LNGFR gene expression in ROS 17/2.8 cells[J]. Mol Cell Endocrinol, 1996, 116(2): 149-156.
[9] 刘诚, 张记恩. 神经生长因子对骨折愈合的影响[J]. 创伤外科杂志, 2011, 13(3): 276-278.
[10] 刘建军, 黄亮, 韩庆斌, 等. α-硫辛酸联合神经生长因子可促进股骨骨折的愈合[J]. 中国组织工程研究, 2016, 20(37): 5477-5482.
[11] 胡海棠, 林英勇, 扈会平. 鼠神经生长因子随机双盲安慰剂对照ⅠⅡⅢ期临床试验中注射部位疼痛的综合分析[J]. 中国药物警戒, 2010, 7(7): 397-400.
[12] 梁艳, 周海燕, 叶小聪, 等. Z径路法结合留置气泡技术减轻注射用鼠神经生长因子肌内注射时疼痛的效果评价[J]. 护士进修杂志, 2017, 32(7): 651-652.
[13] 杨妍, 滕小萍, 杨宝勤, 等. 应用注意力转移法降低鼠神经生长因子肌肉注射过程中的疼痛[J]. 中国老年保健医学, 2015, 13(5): 115-116.
[14] 刘佳, 李莉, 胡会娟, 等. 不同道地产区大黄功效组分含量的差异分析[J]. 中国现代中药, 2017, 19(5): 662-669.
[15] 陈西平. 影响黄连在复方中功效发挥方向的多因素研究[D]. 成都: 成都中医药大学, 2011.
[16] 陈阳峰, 钟晓红. 黄柏的药理作用及其活性成分提取[J]. 作物研究, 2015, 29(5): 564-568.
[17] 郭玉荣. 金黄膏外敷缓解鼠神经生长因子注射疼痛39例[J]. 云南中医中药杂志, 2017, 38(7): 96-97.
[18] 刀琳, 李虹霖, 唐月, 等. 四黄软膏外敷治疗留置针所致输液性静脉炎30例[J]. 中国中医药现代远程教育, 2017, 15(17): 131.
[2] XI-GUANG SANG, ZHI-YONG WANG, LIN CHENG, et al. Analysis of the mechanism by which nerve growth factor promotes callus formation in mice with tibial fracture[J]. Exp Ther Med. 2017, 13(4): 1376-1380.
[3] 张丽霞, 张凡, 卢锦森. “品管圈”活动减轻脊柱骨科肌肉注射鼠神经生长因子疼痛的疗效评价[J]. 护理研究, 2015, 29(2A): 464-466.
[4] 张开放, 郭忠卫, 宋焕瑾. 鼠神经生长因子对腰椎间盘突出患者术后神经恢复的作用[J]. 中国康复理论与实践, 2012, 18(1): 84-86.
[5] 郑兰飞, 周宝灵, 程卫珍, 等. 硫酸镁湿敷联合艾盐包温灸预防鼠神经生长因子肌肉注射后硬结与疼痛的疗效观察[J]. 护士进修杂志, 2018, 33(5): 441-443.
[6] DERBY R, SEO K S, KAZALA K, et al. A factor analysis of lumbar intradiscal electrothermal annuloplasty outcomes[J]. Spine J, 2005, 5(3): 256-261.
[7] 刘宇涛, 黄潮桐, 陈隆福, 等. 鼠神经生长因子治疗胫骨骨不连效果的实验研究[J]. 中国临床解剖学杂志, 2016, 34(3): 326-330.
[8] JEHAN F, NAVEILHAN P, NEVEU I, et al. Regulation of NGF, BDNF and LNGFR gene expression in ROS 17/2.8 cells[J]. Mol Cell Endocrinol, 1996, 116(2): 149-156.
[9] 刘诚, 张记恩. 神经生长因子对骨折愈合的影响[J]. 创伤外科杂志, 2011, 13(3): 276-278.
[10] 刘建军, 黄亮, 韩庆斌, 等. α-硫辛酸联合神经生长因子可促进股骨骨折的愈合[J]. 中国组织工程研究, 2016, 20(37): 5477-5482.
[11] 胡海棠, 林英勇, 扈会平. 鼠神经生长因子随机双盲安慰剂对照ⅠⅡⅢ期临床试验中注射部位疼痛的综合分析[J]. 中国药物警戒, 2010, 7(7): 397-400.
[12] 梁艳, 周海燕, 叶小聪, 等. Z径路法结合留置气泡技术减轻注射用鼠神经生长因子肌内注射时疼痛的效果评价[J]. 护士进修杂志, 2017, 32(7): 651-652.
[13] 杨妍, 滕小萍, 杨宝勤, 等. 应用注意力转移法降低鼠神经生长因子肌肉注射过程中的疼痛[J]. 中国老年保健医学, 2015, 13(5): 115-116.
[14] 刘佳, 李莉, 胡会娟, 等. 不同道地产区大黄功效组分含量的差异分析[J]. 中国现代中药, 2017, 19(5): 662-669.
[15] 陈西平. 影响黄连在复方中功效发挥方向的多因素研究[D]. 成都: 成都中医药大学, 2011.
[16] 陈阳峰, 钟晓红. 黄柏的药理作用及其活性成分提取[J]. 作物研究, 2015, 29(5): 564-568.
[17] 郭玉荣. 金黄膏外敷缓解鼠神经生长因子注射疼痛39例[J]. 云南中医中药杂志, 2017, 38(7): 96-97.
[18] 刀琳, 李虹霖, 唐月, 等. 四黄软膏外敷治疗留置针所致输液性静脉炎30例[J]. 中国中医药现代远程教育, 2017, 15(17): 131.