西酞普兰治疗首发抑郁症老年患者效果及对血清中脑源性神经营养因子和神经肽Y的影响
摘要
目的观察西酞普兰对首发抑郁症老年患者的疗效及血清中脑源性神经生长因子(BDNF)和神经肽(NP)Y的影响。方法 82例首发抑郁症的老年患者编号后应用随机数字表法分为观察组和对照组各41例,对照组应用氟西汀,观察组应用西酞普兰,共治疗6 w,应用汉密顿抑郁量表(HAMD)评价治疗效果,同时观察血清中BDNF和NPY水平变化。结果观察组与对照组治疗后1、2、4、6 w末HAMD评分差异有统计学意义,治疗6 w后两组血清中BDNF和NPY的表达均升高,但是观察组BDNF和NPY的升高值明显高于对照组(均P<0.05)。结论西酞普兰对首发抑郁症老年患者的疗效明显,且起效快,同时能有效上调血清中BDNF和NPY的表达。
引文
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7 陈兴阳,汤义平.安非他酮缓释片治疗抑郁症患者的效果及对血清P物质和神经肽Y水平的影响[J].中国医药导报,2014;11(9):107-9.
8 Hosang GM,Shiles C,Tansey KE,et al.Interaction between stress and the BDNF,Val66Met polymorphism in depression:a systematic review and meta-analysis[J].BMC Med,2014;12(1):199-200.
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10 Vasquez CE,Riener R,Reynolds E,et al.NMDA receptor dysregulation in chronic state:a possible mechanism underlying depression with BDNF downregulation[J].Neurochem Int,2014;79(9):88-97.
11 Liu Y,Lan N,Ren J,et al.Orientin improves depression-like behavior and BDNF in chronic stressed mice[J].Molec Nutr Food Res,2015;59(6):1130-42.
12 Ozsoy S,Olguner EO,Abdulrezzak U.The effects of antidepressants on neuropeptide Y in patients with depression and anxiety[J].Pharmacopsychiatry,2016;49(1):26-31.
13 Wagner L,Kaestner F,Wolf R,et al.Identifying neuropeptide Y(NPY)as the main stress-related substrate of dipeptidyl peptidase 4(DPP4)in blood circulation[J].Neuropeptides,2016;57(2):21-34.
14 冯劼.四逆散对抑郁模型大鼠血浆NPY、SP、SS含量的影响[J].浙江中医杂志,2011;46(8):566-7.
15 马征,庞久玲,刘丹,等.烧伤后康复期老年患者抑郁评分与血清P物质和神经肽Y表达的关系研究[J].中国全科医学,2013;16(29):3447-9.
16 黄茹燕,徐曙,方群,等.首发抑郁症患者西酞普兰治疗前后血清神经肽与细胞因子水平研究[J].南京医科大学学报(自然科学版),2014;34(5):641-4.
17 杜瑜,李焕德.抗抑郁新药西酞普兰的药代动力学[J].中国临床药理学杂志,2005;21(4):307-10.
18 杨艳芬,武克文,刘志芬,等.102例重性抑郁症西酞普兰治疗前后生活质量比较及影响因素分析[J].中国民康医学,2010;22(17):2215-8.
19 李娜,刘芳,许秀峰.西酞普兰与帕罗西汀治疗抑郁症对照研究[J].精神医学杂志,2005;18(2):91-2.
2 吕永良,吴爱勤,李鸣,等.老年抑郁症的心理社会因素研究[J].中国心理卫生杂志,2004;18(4):254-6.
3 Platenik J,Fisar Z,Buchal R,et al.GSK3β,CREB and BDNF in peripheral blood of patients with Alzheimer's disease and depression[J].Prog Neuro-Psychopharmacol Biol Psych,2014;50(2):83-93.
4 Molendijk ML,Spinhoven P,Polak M,et al.Serum BDNF concentrations as peripheral manifestations of depression:evidence from a systematic review and meta-analyses on 179 associations[J].Molec Psych,2014;19(7):791-800.
5 Desai SJ,Borkar CD,Nakhate KT,et al.Neuropeptide Y attenuates anxiety-and depression-like effects of cholecystokinin-4 in mice[J].Neuroscience,2014;277(10):818-30.
6 栗大顺,于建新,庞月岱.西酞普兰与文拉法辛治疗抑郁症的对照研究[J].临床精神医学杂志,2005;15(3):158-9.
7 陈兴阳,汤义平.安非他酮缓释片治疗抑郁症患者的效果及对血清P物质和神经肽Y水平的影响[J].中国医药导报,2014;11(9):107-9.
8 Hosang GM,Shiles C,Tansey KE,et al.Interaction between stress and the BDNF,Val66Met polymorphism in depression:a systematic review and meta-analysis[J].BMC Med,2014;12(1):199-200.
9 Jehn CF,Becker B,Flath B,et al.Neurocognitive function,brain-derived neurotrophic factor(BDNF)and IL-6 levels in cancer patients with depression[J].High Temper Mater Proc,2015;16(2):116-20.
10 Vasquez CE,Riener R,Reynolds E,et al.NMDA receptor dysregulation in chronic state:a possible mechanism underlying depression with BDNF downregulation[J].Neurochem Int,2014;79(9):88-97.
11 Liu Y,Lan N,Ren J,et al.Orientin improves depression-like behavior and BDNF in chronic stressed mice[J].Molec Nutr Food Res,2015;59(6):1130-42.
12 Ozsoy S,Olguner EO,Abdulrezzak U.The effects of antidepressants on neuropeptide Y in patients with depression and anxiety[J].Pharmacopsychiatry,2016;49(1):26-31.
13 Wagner L,Kaestner F,Wolf R,et al.Identifying neuropeptide Y(NPY)as the main stress-related substrate of dipeptidyl peptidase 4(DPP4)in blood circulation[J].Neuropeptides,2016;57(2):21-34.
14 冯劼.四逆散对抑郁模型大鼠血浆NPY、SP、SS含量的影响[J].浙江中医杂志,2011;46(8):566-7.
15 马征,庞久玲,刘丹,等.烧伤后康复期老年患者抑郁评分与血清P物质和神经肽Y表达的关系研究[J].中国全科医学,2013;16(29):3447-9.
16 黄茹燕,徐曙,方群,等.首发抑郁症患者西酞普兰治疗前后血清神经肽与细胞因子水平研究[J].南京医科大学学报(自然科学版),2014;34(5):641-4.
17 杜瑜,李焕德.抗抑郁新药西酞普兰的药代动力学[J].中国临床药理学杂志,2005;21(4):307-10.
18 杨艳芬,武克文,刘志芬,等.102例重性抑郁症西酞普兰治疗前后生活质量比较及影响因素分析[J].中国民康医学,2010;22(17):2215-8.
19 李娜,刘芳,许秀峰.西酞普兰与帕罗西汀治疗抑郁症对照研究[J].精神医学杂志,2005;18(2):91-2.