丁苯酞软胶囊联合银杏叶提取物注射液治疗急性脑梗死的临床效果观察
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摘要
目的:观察丁苯酞软胶囊联合银杏叶提取物注射液治疗急性脑梗死的临床效果。方法:选取480例急性脑梗死患者作为研究对象,采用随机数字表法将其分为对照组和观察组各240例。两组均给予内科规范治疗,同时对照组给予丁苯酞软胶囊治疗,观察组在对照组基础上给予银杏叶提取物注射液治疗。比较两组临床疗效、神经功能改善情况(NIHSS)、自理能力改善情况(ADL)、炎症因子水平(IL-6、hs-CRP)、血液流变学指标(血浆黏度、全血高切黏度、全血低切黏度、红细胞比容、血小板聚集率)情况。结果:观察组治疗总有效率为94.58%,明显高于对照组的79.58%,差异有统计学意义(P<0.05);治疗后观察组NIHSS评分明显低于对照组,ADL评分明显高于对照组,IL-6、hs-CRP水平、血浆黏度、全血高切黏度、全血低切黏度、红细胞压积、血小板聚集率均明显低于对照组,差异均有统计学意义(P<0.05)。结论:丁苯酞软胶囊联合银杏叶提取物注射液治疗急性脑梗死的临床效果优于单纯丁苯酞软胶囊治疗效果。
Objective: To investigate clinical effects of Butylphthalide soft capsules combined with extract of Ginkgo biloba leaves injection in treatment of acute cerebral infarction. Methods: 480 patients with acute cerebral infarction were selected as the study subjects, and they were divided into control group and observation group according to the random number table method, 240 cases in each. Both groups were given standard medical treatment. Besides, the control group was treated with Butylphthalide soft capsules, while the observation group was given extract of Ginkgo biloba leaves injection on the basis of that of the control group. The clinical effects, neurological function improvement(NIHSS), self-care ability improvement(ADL), inflammatory factor levels(IL-6, hs-CRP) and hemorheology indexes(plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, platelet aggregation rate) were compared between the two groups. Results: The total effective rate of the observation group was 94.58%, which was significantly higher than that of the control group(79.58%), and the difference was statistically significant(P<0.05). After the treatment, the NIHSS score of the observation group was significantly lower than that of the control group, the ADL score was significantly higher than that of the control group, the levels of IL-6, hs-CRP, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, and platelet aggregation rate were significantly lower than the control group, and the differences were statistically significant(P<0.05). Conclusions: Butylphthalide soft capsules combined with extract of Ginkgo biloba leaves injection in the treatment of acute cerebral infarction is superior to single Butylphthalide soft capsules.
Objective: To investigate clinical effects of Butylphthalide soft capsules combined with extract of Ginkgo biloba leaves injection in treatment of acute cerebral infarction. Methods: 480 patients with acute cerebral infarction were selected as the study subjects, and they were divided into control group and observation group according to the random number table method, 240 cases in each. Both groups were given standard medical treatment. Besides, the control group was treated with Butylphthalide soft capsules, while the observation group was given extract of Ginkgo biloba leaves injection on the basis of that of the control group. The clinical effects, neurological function improvement(NIHSS), self-care ability improvement(ADL), inflammatory factor levels(IL-6, hs-CRP) and hemorheology indexes(plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, platelet aggregation rate) were compared between the two groups. Results: The total effective rate of the observation group was 94.58%, which was significantly higher than that of the control group(79.58%), and the difference was statistically significant(P<0.05). After the treatment, the NIHSS score of the observation group was significantly lower than that of the control group, the ADL score was significantly higher than that of the control group, the levels of IL-6, hs-CRP, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, and platelet aggregation rate were significantly lower than the control group, and the differences were statistically significant(P<0.05). Conclusions: Butylphthalide soft capsules combined with extract of Ginkgo biloba leaves injection in the treatment of acute cerebral infarction is superior to single Butylphthalide soft capsules.
引文
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[4]丁荣椿,罗亮,刘向红,等.阿替普酶联合丁苯酞治疗超急性期脑梗死效果观察[J].临床合理用药杂志,2015,8(25):9-11.
[5]宋雨阳.丁苯酞对急性脑梗死患者血清细胞因子、神经功能及血液流变学的影响[J].中国医学创新,2018,15(9):31-34.
[6]兰朝阳,张淑红.丁苯酞联合银杏叶对急性脑梗死血液流变学指标和血脂水平的影响及疗效观察[J].中华中医药学刊,2015,33(7):1759-1761.
[7]王军文.丁苯酞联合银杏叶提取物对急性脑梗死患者血液流变学和血脂水平的影响[J].实用临床医药杂志,2016,20(11):150-151.
[8]洪冰聪,王杰华,留晓强.银杏叶提取物联合丁苯酞软胶囊治疗急性脑梗死的疗效观察[J].世界临床医学,2015,9(5):152.
[9]詹霞,蒋东晓,孙新虎,等.丁苯酞联合银杏叶提取物注射液治疗大面积脑梗死的临床研究[J].现代药物与临床,2018,33(1):54-58.
[10]包萨如拉,孟云清.银杏叶注射液联合丁苯酞注射液高压氧治疗进展性脑梗死临床分析[J].中国实用神经疾病杂志,2016,19(8):116-117.
[2]胡以慧,朱双成,岑跃南.丁苯酞软胶囊联合银杏达莫治疗急性脑梗死的临床研究[J].中外医学研究,2013,11(19):10-12.
[3]中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南[J].中华神经科杂志,2010,43(2):1-53.
[4]丁荣椿,罗亮,刘向红,等.阿替普酶联合丁苯酞治疗超急性期脑梗死效果观察[J].临床合理用药杂志,2015,8(25):9-11.
[5]宋雨阳.丁苯酞对急性脑梗死患者血清细胞因子、神经功能及血液流变学的影响[J].中国医学创新,2018,15(9):31-34.
[6]兰朝阳,张淑红.丁苯酞联合银杏叶对急性脑梗死血液流变学指标和血脂水平的影响及疗效观察[J].中华中医药学刊,2015,33(7):1759-1761.
[7]王军文.丁苯酞联合银杏叶提取物对急性脑梗死患者血液流变学和血脂水平的影响[J].实用临床医药杂志,2016,20(11):150-151.
[8]洪冰聪,王杰华,留晓强.银杏叶提取物联合丁苯酞软胶囊治疗急性脑梗死的疗效观察[J].世界临床医学,2015,9(5):152.
[9]詹霞,蒋东晓,孙新虎,等.丁苯酞联合银杏叶提取物注射液治疗大面积脑梗死的临床研究[J].现代药物与临床,2018,33(1):54-58.
[10]包萨如拉,孟云清.银杏叶注射液联合丁苯酞注射液高压氧治疗进展性脑梗死临床分析[J].中国实用神经疾病杂志,2016,19(8):116-117.