氟伏沙明联合利培酮对强迫症患者临床症状及认知功能的影响
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摘要
目的探讨氟伏沙明联合利培酮对强迫症患者临床症状及认知功能的影响。方法选取我院2016年10月至2018年10月收治的82例强迫症患者,随机分为两组各41例。对照组单纯给予氟伏沙明治疗,观察组给予氟伏沙明联合利培酮治疗,比较两组的临床疗效及认知功能。结果观察组的治疗总有效率为82.93%,显著高于对照组的63.41%(P <0.05)。治疗后,两组患者的TESS评分无显著差异(P>0.05)。治疗后,观察组的Y-BOCS评分显著低于对照组(P <0.01),操作智商、记忆商数、短时记忆评分均显著高于对照组(P <0.05)。结论氟伏沙明联合利培酮治疗强迫症患者安全有效,可明显改善患者的认知功能。
Objective To explore the effect of fluvoxamine combined with risperidone on clinical symptoms and cognition function of obsessive-compulsive disorder patients. Methods 82 cases of patients with obsessive-compulsive disorder in our hospital from October2016 to October 2018 were randomly divided into two groups, with 41 cases in each group. Patients in the control group were treated with fluvoxamine only, while patients in the observation group were treated with fluvoxamine combined with risperidone. The clinical efficacy and cognitive function of the two groups were compared. Results The total effective rate of treatment in the observation group was 82.93%,significantly higher than 63.41% in the control group(P <0.05). After treatment, no significant difference was found in TESS score between the two groups(P >0.05). After treatment, the Y-BOCS score in the observation group was significantly lower than that in the control group(P <0.01), and the scores of operational IQ, memory quotient and short-term memory were significantly higher than those in the control group(P <0.05). Conclusions Fluvoxamine combined with risperidone is safe and effective in the treatment of patients with obsessivecompulsive disorder, and can significantly improve the cognitive function of patients.
Objective To explore the effect of fluvoxamine combined with risperidone on clinical symptoms and cognition function of obsessive-compulsive disorder patients. Methods 82 cases of patients with obsessive-compulsive disorder in our hospital from October2016 to October 2018 were randomly divided into two groups, with 41 cases in each group. Patients in the control group were treated with fluvoxamine only, while patients in the observation group were treated with fluvoxamine combined with risperidone. The clinical efficacy and cognitive function of the two groups were compared. Results The total effective rate of treatment in the observation group was 82.93%,significantly higher than 63.41% in the control group(P <0.05). After treatment, no significant difference was found in TESS score between the two groups(P >0.05). After treatment, the Y-BOCS score in the observation group was significantly lower than that in the control group(P <0.01), and the scores of operational IQ, memory quotient and short-term memory were significantly higher than those in the control group(P <0.05). Conclusions Fluvoxamine combined with risperidone is safe and effective in the treatment of patients with obsessivecompulsive disorder, and can significantly improve the cognitive function of patients.
引文
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[7]王东明,孙平,段妮.氟伏沙明治疗强迫症的疗效和对生活质量的影响[J].临床合理用药杂志, 2016, 9(19):35-36.
[8]赵仁香.探讨氟伏沙明联合利培酮治疗强迫症的临床疗效分析[J].中国卫生标准管理, 2015, 6(12):75-76.
[9]汪春运.强迫症的抗多巴胺药物治疗[J].医药导报, 2015, 34(7):927-929.
[10]郭玲玲,贺俊严.利培酮及氟伏沙明联合用药对难治性强迫症的治疗效果分析[J].中国医药指南, 2017, 15(23):159-160.
[2]段俞戎,吴海苏.强迫症认知功能障碍的研究进展[J].神经疾病与精神卫生, 2017, 17(12):893-898.
[3]万其容,胡亚荣,徐金枝,等.舍曲林联合氨磺必利治疗难治性强迫症的临床研究[J].神经损伤与功能重建, 2016, 11(2):138-140.
[4]高月霞,黄敬,刘华丽,等.米氮平与帕罗西汀治疗强迫症对照研究[J].精神医学杂志, 2015, 28(6):454-456.
[5]郝红,赵宁民,朱雪萍,等.氟伏沙明联合阿立哌唑对强迫症患者临床症状及认知功能的影响[J].国际精神病学杂志, 2017, 44(2):243-246.
[6]何堂礼.氟伏沙明联合利培酮治疗强迫症25例临床分析[J].中国社区医师(医学专业), 2014, 30(19):43-44.
[7]王东明,孙平,段妮.氟伏沙明治疗强迫症的疗效和对生活质量的影响[J].临床合理用药杂志, 2016, 9(19):35-36.
[8]赵仁香.探讨氟伏沙明联合利培酮治疗强迫症的临床疗效分析[J].中国卫生标准管理, 2015, 6(12):75-76.
[9]汪春运.强迫症的抗多巴胺药物治疗[J].医药导报, 2015, 34(7):927-929.
[10]郭玲玲,贺俊严.利培酮及氟伏沙明联合用药对难治性强迫症的治疗效果分析[J].中国医药指南, 2017, 15(23):159-160.