ICAM-1在肿瘤转移中的作用及研究进展
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摘要
ICAM-1是免疫球蛋白超家族成员,是人体内分布最为广泛的细胞间黏附分子,可表达于多种不同组织来源的恶性肿瘤,通过参与肿瘤细胞和血管内皮或中性粒细胞的黏附介导恶性肿瘤的血行转移和淋巴结转移,并通过竞争性抑制血液循环中ICAM-1/LFA-1依赖的MHC-1类抗原对游离肿瘤细胞的免疫识别作用,介导肿瘤细胞的免疫逃逸,参与恶性肿瘤的侵袭和转移过程。深入研究ICAM-1在恶性肿瘤中的表达与功能,有助于进一步认识恶性肿瘤侵袭转移的分子机制,也为恶性肿瘤的诊断和预后判断提供了新的指标。
ICAM-1 is an immunoglobulin superfamily member,which is the intercellular adhesion molecule that is most widely distributed in the human body,which can be expressed in malignant tumour from different tissues. Moreover is involved in the process of invasion and metastasis of malignant tumors,and can mediate the immune escape of tumor cells by competitive inhibition of immunologic recognition effects on ICAM-1/LFA-1 reliant MHC-1 type of antigen as well as by participating in the hematogenous metastasis and lymph node metastasis of malignant tumor mediated by tumor cells,vascular endothelial cells and neutrophilic granulocytes. To research deeply the expression and function of ICAM-1 is helpful to understand the molecular mechanism of invasion and metastasis of malignant tumor,also to provide new indexes for the diagnosis and prognosis evaluation of malignant tumor.
ICAM-1 is an immunoglobulin superfamily member,which is the intercellular adhesion molecule that is most widely distributed in the human body,which can be expressed in malignant tumour from different tissues. Moreover is involved in the process of invasion and metastasis of malignant tumors,and can mediate the immune escape of tumor cells by competitive inhibition of immunologic recognition effects on ICAM-1/LFA-1 reliant MHC-1 type of antigen as well as by participating in the hematogenous metastasis and lymph node metastasis of malignant tumor mediated by tumor cells,vascular endothelial cells and neutrophilic granulocytes. To research deeply the expression and function of ICAM-1 is helpful to understand the molecular mechanism of invasion and metastasis of malignant tumor,also to provide new indexes for the diagnosis and prognosis evaluation of malignant tumor.
引文
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2 Hood JD,Cheresh DA.Role of integrins in cell invasion and migration.Nat Rev Cancer,2002,2:91-100.
3 Shen A,Yang J,Gu Y,et al.Lipopolysaccharide-evoked activation of p38and JNK leads to an increase in ICAM-1 expression in Schwann cells o sciatic nerves.FEBS J,2008,75:4343-4353.
4 Nathan C.Neutrophils and immunity:challenges and opportunities.Na Rev Immunol,2006,6:173-182.
5 Liang S,Fu C,Wagner D,et al.Two-dimensional kinetics ofβ2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow.Am J Physiol Cell Physiol,2008,294:C743-753.
6 Li H,Ge C,Zhao F,et al.Hypoxia-induceible factor-1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1 signaling in human hepatocellular carcinoma.Hematology,2011,4:910-919.
7 Li M,Gao CJ.An update onβ2 integrin LFA-1 and ligand ICAM-1Signaling.Journal of Experimental Hematology,2008,16:213-216.
8 De Vita F,Infusino S,Auriemma A,et al.Circulating levels of soluble intercellular adhesion molecule-1 in non-small cell lung cancer patients.Oncology Reports,1998,5:393-399.
9夏宗江,赵松,王家祥.肺癌组织中ICAM-1测定的临床意义.医学信息·手术学分册,2007,20:531-532.
10刘向阳,王旭广,许江宾,等.肺癌根治对s ICAM-1表达的影响研究河南外科学杂志,2016,22:33-35.
11夏漫辉,冷云华.血s ICAM-1、s VCAM-1水平与肺鳞癌关系的研究.中国血液流变学杂志,2012,22:637-638.
12卞晓洁,陈平.血清MMP-9和ICAM-1水平对非小细胞肺癌骨转移诊断和预后的意义.临床肿瘤学杂志,2010,15:680-684.
13刘子梅,余文熙.ICAM-1在三阴性乳腺癌中的表达的临床意义及与预后的关系.中国癌症杂志,2017,27:121-127.
14吴琼,王堃,向满林,等.可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义.实用预防医学,2016,23:630-633.
15孙亚欣,张志超,贾明库.CD40与ICAM-1在原发性肝细胞癌组织中的表达及临床意义.吉林大学学报·医学版,2009,35:348-351,398.
16何雄文,张伟.细胞间黏附分子-1与肝细胞癌关系的研究.现代预防医学,2011,38:4953-4954,4960.
17陈洁,姚登福.s ICAM-1定量检测对肝细胞性肝癌诊断与预后的临床价值分析.南通大学学报·医学版,2012,32:180-182.
18邵建富,王敬瑄.CD105和细胞间粘附分子-1在胃癌中的表达及意义.河北医药,2012,34:2725-2727.
19李艳,章明放,郭雪西.结直肠癌患者组织和外周血中细胞黏附分子-1和血管细胞黏附分子-1的表达及临床意义.中国肿瘤临床与康复,2016,23:903-905.
20殷积彬,李宝馨.MMP-2和ICAM-1在裸鼠体内塞来昔布抑制肝癌组织中的表达.世界华人消化杂志,2010,18:1206-1210.
21梁翙,丁健民.TNF-α与IL-1β对胃癌腹膜间皮细胞黏附分子mRNA表达的影响.胃肠病学和肝病学杂志,2014,23:252-255.
22张红梅,安广宇.RNA干扰MMP-9表达对人纤维肉瘤细胞系HT1080侵袭转移的影响.中国肿瘤临床,2010,48:1425-1431.
23白洪波,王昀.腺苷酸活化蛋白激酶活化对单核细胞-内皮细胞黏附的影响及其机制.生理学报,2016,68:41-49.
24黄恺飞.藤黄酸诱导胃癌细胞凋亡及抗肿瘤转移的实验研究.中草药,2010,41:1823-1828.
25黄恺飞,庄媛.汉黄芩素抑制乳腺癌细胞增殖及侵袭的实验研究.中国中药杂志,2014,39:1485-1489.
26蒋瑞彬,黄晶晶.白及须根醇提物诱导肺腺癌细胞A549凋亡研究.云南中医学院学报,2015,38:12-17.
27 Chen J,Shi DY,Liu SL,et al.Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo.Oncol Rep,2012,27:523-528.
28 Zhang Y,Wei RX,Zhu XB,et al.Tanshinone IIA induces apoptosis and inhibits the proliferation,migration,and invasion of the osteosarcoma MG-63 cell line in vitro.Anticancer Drugs,2012,23:212-219.
29赵雪峰,贾楠.丹参酮ⅡA对胃癌细胞迁移和侵袭能力的抑制作用及机制.中国癌症杂志,2013,23:793-797.
30李强,陈德.E-selectin和ICAM-1在肝癌细胞与血管内皮细胞黏附作用中的实验研究.岭南现代临床外科,2009,9:327-330.
31何秀娟,林燕,蒙玉娇,等.桂皮醛抑制血管内皮细胞与中性粒细胞黏附及其分子机制.中国临床药理学与治疗学,2017,22:43-47.
32何晓乐,王晓明.姜黄素在内脂素诱导内皮细胞炎症损伤中的作用机制.中华老年多器官疾病杂志,2017,16:203-207.
33杨富国,刘革新.黄芪甲苷对缺氧/复氧损伤人脐静脉内皮细胞与中性粒细胞黏附能力及细胞核转录因子κB表达的影响.中国组织工程研究与临床康复,2008,12:2843-2846.
34修春,宓穗卿,王宁生.隐丹参酮对TNF-α诱导的人脐静脉内皮细胞粘附分子ICAM-1表达的作用.中药药理与临床,2009,25:16-19.
2 Hood JD,Cheresh DA.Role of integrins in cell invasion and migration.Nat Rev Cancer,2002,2:91-100.
3 Shen A,Yang J,Gu Y,et al.Lipopolysaccharide-evoked activation of p38and JNK leads to an increase in ICAM-1 expression in Schwann cells o sciatic nerves.FEBS J,2008,75:4343-4353.
4 Nathan C.Neutrophils and immunity:challenges and opportunities.Na Rev Immunol,2006,6:173-182.
5 Liang S,Fu C,Wagner D,et al.Two-dimensional kinetics ofβ2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow.Am J Physiol Cell Physiol,2008,294:C743-753.
6 Li H,Ge C,Zhao F,et al.Hypoxia-induceible factor-1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1 signaling in human hepatocellular carcinoma.Hematology,2011,4:910-919.
7 Li M,Gao CJ.An update onβ2 integrin LFA-1 and ligand ICAM-1Signaling.Journal of Experimental Hematology,2008,16:213-216.
8 De Vita F,Infusino S,Auriemma A,et al.Circulating levels of soluble intercellular adhesion molecule-1 in non-small cell lung cancer patients.Oncology Reports,1998,5:393-399.
9夏宗江,赵松,王家祥.肺癌组织中ICAM-1测定的临床意义.医学信息·手术学分册,2007,20:531-532.
10刘向阳,王旭广,许江宾,等.肺癌根治对s ICAM-1表达的影响研究河南外科学杂志,2016,22:33-35.
11夏漫辉,冷云华.血s ICAM-1、s VCAM-1水平与肺鳞癌关系的研究.中国血液流变学杂志,2012,22:637-638.
12卞晓洁,陈平.血清MMP-9和ICAM-1水平对非小细胞肺癌骨转移诊断和预后的意义.临床肿瘤学杂志,2010,15:680-684.
13刘子梅,余文熙.ICAM-1在三阴性乳腺癌中的表达的临床意义及与预后的关系.中国癌症杂志,2017,27:121-127.
14吴琼,王堃,向满林,等.可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义.实用预防医学,2016,23:630-633.
15孙亚欣,张志超,贾明库.CD40与ICAM-1在原发性肝细胞癌组织中的表达及临床意义.吉林大学学报·医学版,2009,35:348-351,398.
16何雄文,张伟.细胞间黏附分子-1与肝细胞癌关系的研究.现代预防医学,2011,38:4953-4954,4960.
17陈洁,姚登福.s ICAM-1定量检测对肝细胞性肝癌诊断与预后的临床价值分析.南通大学学报·医学版,2012,32:180-182.
18邵建富,王敬瑄.CD105和细胞间粘附分子-1在胃癌中的表达及意义.河北医药,2012,34:2725-2727.
19李艳,章明放,郭雪西.结直肠癌患者组织和外周血中细胞黏附分子-1和血管细胞黏附分子-1的表达及临床意义.中国肿瘤临床与康复,2016,23:903-905.
20殷积彬,李宝馨.MMP-2和ICAM-1在裸鼠体内塞来昔布抑制肝癌组织中的表达.世界华人消化杂志,2010,18:1206-1210.
21梁翙,丁健民.TNF-α与IL-1β对胃癌腹膜间皮细胞黏附分子mRNA表达的影响.胃肠病学和肝病学杂志,2014,23:252-255.
22张红梅,安广宇.RNA干扰MMP-9表达对人纤维肉瘤细胞系HT1080侵袭转移的影响.中国肿瘤临床,2010,48:1425-1431.
23白洪波,王昀.腺苷酸活化蛋白激酶活化对单核细胞-内皮细胞黏附的影响及其机制.生理学报,2016,68:41-49.
24黄恺飞.藤黄酸诱导胃癌细胞凋亡及抗肿瘤转移的实验研究.中草药,2010,41:1823-1828.
25黄恺飞,庄媛.汉黄芩素抑制乳腺癌细胞增殖及侵袭的实验研究.中国中药杂志,2014,39:1485-1489.
26蒋瑞彬,黄晶晶.白及须根醇提物诱导肺腺癌细胞A549凋亡研究.云南中医学院学报,2015,38:12-17.
27 Chen J,Shi DY,Liu SL,et al.Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo.Oncol Rep,2012,27:523-528.
28 Zhang Y,Wei RX,Zhu XB,et al.Tanshinone IIA induces apoptosis and inhibits the proliferation,migration,and invasion of the osteosarcoma MG-63 cell line in vitro.Anticancer Drugs,2012,23:212-219.
29赵雪峰,贾楠.丹参酮ⅡA对胃癌细胞迁移和侵袭能力的抑制作用及机制.中国癌症杂志,2013,23:793-797.
30李强,陈德.E-selectin和ICAM-1在肝癌细胞与血管内皮细胞黏附作用中的实验研究.岭南现代临床外科,2009,9:327-330.
31何秀娟,林燕,蒙玉娇,等.桂皮醛抑制血管内皮细胞与中性粒细胞黏附及其分子机制.中国临床药理学与治疗学,2017,22:43-47.
32何晓乐,王晓明.姜黄素在内脂素诱导内皮细胞炎症损伤中的作用机制.中华老年多器官疾病杂志,2017,16:203-207.
33杨富国,刘革新.黄芪甲苷对缺氧/复氧损伤人脐静脉内皮细胞与中性粒细胞黏附能力及细胞核转录因子κB表达的影响.中国组织工程研究与临床康复,2008,12:2843-2846.
34修春,宓穗卿,王宁生.隐丹参酮对TNF-α诱导的人脐静脉内皮细胞粘附分子ICAM-1表达的作用.中药药理与临床,2009,25:16-19.