益胃活血汤治疗气滞血瘀型急性胃炎的临床效果
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摘要
目的分析益胃活血汤治疗气滞血瘀型急性胃炎患者的临床效果。方法选择中国中医科学院望京医院2016年2月～2017年12月收治的120例气滞血瘀型急性胃炎患者,采用随机数字表法将其分为两组,对照组60例应用常规西医治疗,观察组60例在西医治疗的基础上结合益胃活血汤治疗。连续治疗2周后,比较两组临床疗效、中医症状积分、胃泌素和胃动素水平,以及安全性。结果观察组和对照组治疗后上脘疼痛、食欲下降及呕吐或呕血积分均明显低于治疗前(t=20.612、22.796、19.474,均P <0.05;t=16.095、18.724、15.163,均P <0.05),且观察组治疗后上脘疼痛、食欲下降及呕吐或呕血积分明显低于对照组(t=10.067、14.858、13.267,均P <0.05)。观察组总有效率明显高于对照组,差异有统计学意义(χ~2=5.55,P <0.05)。观察组和对照组治疗后胃泌素、胃动素水平均明显高于治疗前(t=5.353,11.277,均P <0.05;t=2.715、5.571,均P <0.05),且观察组治疗后胃泌素及胃动素水平明显高于对照组,差异有统计学意义(t=11.727、20.782,均P <0.05)。观察组总不良反应发生率低于对照组(χ~2=11.36,P <0.05)。结论益胃活血汤治疗气滞血瘀型急性胃炎可有效改善患者症状、胃肠功能,且安全可靠,应用价值显著。
Objective To analyze the clinical efficacy of Yiwei Huoxue Decoction in the treatment of acute gastritis patients with syndrome of qi stagnation and blood stasis. Methods One hundred and twenty acute gastritis patients with syndrome of qi stagnation and blood stasis admitted to Wangjing Hospital of China Academy of Chinese Medical Sciences from February 2016 to December 2017 were selected and divided into two groups by random number table method. 60 patients in the control group were treated with conventional Western medicine, 60 patients in the observation group were added with Yiwei Huoxue Decoction on the basis of Western medicine. After 2 weeks of continuous treatment, the clinical efficacy and TCM symptom scores, the levels of gastrin and motilin, and the safety were compared between the two groups. Results The scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group and the control group were all lower than those before treatment(t = 20.612, 22.796, 19.474, all P < 0.05; t = 16.095, 18.724, 15.163, all P < 0.05), and the scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group were lower than those of the control group after treatment(t = 10.067, 14.858,13.267, all P < 0.05). The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant(χ~2= 5.55, P < 0.05). The levels of gastrin and motilin in the observation group and the control group were alll higher than those before treatment(t = 5.353, 11.277, all P < 0.05; t = 2.715, 5.571, all P < 0.05), and the levels of gastrin and motilin in the observation group were alll higher than those of the control group,the differences were statistically significant(t = 11.727, 20.782, all P < 0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group(χ~2= 11.36, P < 0.05). Conclusion Yiwei Huoxue Decoction can effectively improve the symptoms and gastrointestinal function of acute gastritis patients with syndrome of qi stagnation and blood stasis, it is safe and reliable, and it has significant application value.
Objective To analyze the clinical efficacy of Yiwei Huoxue Decoction in the treatment of acute gastritis patients with syndrome of qi stagnation and blood stasis. Methods One hundred and twenty acute gastritis patients with syndrome of qi stagnation and blood stasis admitted to Wangjing Hospital of China Academy of Chinese Medical Sciences from February 2016 to December 2017 were selected and divided into two groups by random number table method. 60 patients in the control group were treated with conventional Western medicine, 60 patients in the observation group were added with Yiwei Huoxue Decoction on the basis of Western medicine. After 2 weeks of continuous treatment, the clinical efficacy and TCM symptom scores, the levels of gastrin and motilin, and the safety were compared between the two groups. Results The scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group and the control group were all lower than those before treatment(t = 20.612, 22.796, 19.474, all P < 0.05; t = 16.095, 18.724, 15.163, all P < 0.05), and the scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group were lower than those of the control group after treatment(t = 10.067, 14.858,13.267, all P < 0.05). The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant(χ~2= 5.55, P < 0.05). The levels of gastrin and motilin in the observation group and the control group were alll higher than those before treatment(t = 5.353, 11.277, all P < 0.05; t = 2.715, 5.571, all P < 0.05), and the levels of gastrin and motilin in the observation group were alll higher than those of the control group,the differences were statistically significant(t = 11.727, 20.782, all P < 0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group(χ~2= 11.36, P < 0.05). Conclusion Yiwei Huoxue Decoction can effectively improve the symptoms and gastrointestinal function of acute gastritis patients with syndrome of qi stagnation and blood stasis, it is safe and reliable, and it has significant application value.
引文
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[20]孟红艳,马宏博,张光波,等.中医药治疗慢性浅表性胃炎辨证用药规律分析[J].中国医药导报,2016,13(7):84-86.
[21]吴强.芍连胃乐片治疗肝郁气滞型慢性萎缩性胃炎32例[J].西部中医药,2017,30(10):77-78.
[22]Tan J,Wang Y,Sun X,et al.The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease[J].Am J Med Sci,2015,349(4):364-371.
[23]李海蓉,朱楠,叶红,等.自拟理气活血益胃汤治疗慢性萎缩性胃炎的临床分析[J].国际医药卫生导报,2016,22(11):1618-1620.
[24]陈庆.活血止痛中药配合西药治疗急性胃炎患者临床疗效观察及对血清胃泌素和胃动素的影响[J].陕西中医,2015,36(8):956-958.
[2]孟飞,吴琴.急性胃炎临床超声的诊断与鉴别诊断探究[J].现代消化及介入诊疗,2015,20(4):376-377.
[3]温洪钟,余旭辉,范茂春.中西医结合治疗肝胃不和型急性胃炎60例临床观察[J].中国现代药物应用,2017,11(20):118-120.
[4]黄淑顺,李敏.藿香正气丸联合磷酸铝凝胶治疗急性胃肠炎的临床研究[J].现代药物与临床,2017,32(8):1470-1473.
[5]龚国彪,梁建.山良菪碱、奥美拉唑联合阿托品治疗急性胃炎疗效观察[J].海南医学,2016,27(17):2841-2843.
[6]李建芝,高鹏.枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎的临床研究[J].现代药物与临床,2016,31(8):1201-1204.
[7]白晓莉.间苯三酚联合依替米星对急性胃肠炎痉挛性腹痛患者疼痛症状及炎症因子水平的影响分析[J].实用医院临床杂志,2017,14(6):176-178.
[8]宋淑芳.中西医结合治疗慢性浅表性胃炎临床研究[J].中医学报,2015,11(9):1348-1350.
[9]Dinca EB,Skinner A,Dinca RV,et al.The dangers of gastritis:a case of clarithromycin-associated brief psychotic episode[J].J Nerv Ment Dis,2015,203(2):149-151.
[10]哲剑虹.中西医结合治疗脾胃湿热型慢性胃炎临床研究[J].中医学报,2017,32(6):1055-1058.
[11]刘晓欣,周淑芬,刘明钊,等.注射用泮托拉唑钠治疗急慢性胃炎的疗效观察[J].中国医院用药评价与分析,2017,17(7):929-930.
[12]蔡鑫桂,林晓燕,赵帅,等.平衡针联合四黄水蜜外敷治疗急性胃肠炎疗效观察[J].浙江中医药大学学报,2015,39(2):153-154.
[13]Benitez PR,Nogueira CS,Holanda AC,et al.Lumbar spinal anesthesia with cervical nociceptive blockade.Critical review of a series of 1330 procedures[J].Rev Bras Anestesiol,2016,66(1):86-93.
[14]赵素娟.注射用泮托拉唑钠不良反应的分析[J].临床医药文献电子杂志,2017,4(41):8083.
[15]王豹.中医辩证辩病治疗慢性胃炎伴胆汁反流疗效观察[J].环球中医药,2015,8(s1):79-80.
[16]秦瞻.中医治疗慢性胃炎的临床思路构建和探索[J].世界中医药,2016,11(3):459.
[17]崔世军,高艺真.香砂养胃汤联合温针治疗慢性浅表性胃炎66例[J].西部中医药,2017,30(12):65-67.
[18]林柳兵,阙任烨,沈艳婷,等.慢性浅表性胃炎的中西医研究进展[J].陕西中医,2016,37(8):1099-1101.
[19]黎友隆.健脾通络汤治疗脾胃虚弱型慢性萎缩性胃炎的效果研究[J].中国医药科学,2017,7(11):56-58.
[20]孟红艳,马宏博,张光波,等.中医药治疗慢性浅表性胃炎辨证用药规律分析[J].中国医药导报,2016,13(7):84-86.
[21]吴强.芍连胃乐片治疗肝郁气滞型慢性萎缩性胃炎32例[J].西部中医药,2017,30(10):77-78.
[22]Tan J,Wang Y,Sun X,et al.The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease[J].Am J Med Sci,2015,349(4):364-371.
[23]李海蓉,朱楠,叶红,等.自拟理气活血益胃汤治疗慢性萎缩性胃炎的临床分析[J].国际医药卫生导报,2016,22(11):1618-1620.
[24]陈庆.活血止痛中药配合西药治疗急性胃炎患者临床疗效观察及对血清胃泌素和胃动素的影响[J].陕西中医,2015,36(8):956-958.