三种子宫内膜准备方案在薄型子宫内膜患者中的应用研究
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摘要
目的探讨薄型子宫内膜患者在冻融胚胎移植周期3种不同方案准备内膜后的临床治疗结局,探讨该类患者适合的冻融胚胎移植方案。方法选取在本院及合作医院接受冻融胚胎解冻移植周期的患者,既往反复内膜厚度监测未超过7 mm者,以患者意愿分为3组:1组采用自然周期,2组采用诱导排卵周期,3组采用激素替代周期。结果对于薄型子宫内膜患者,3组的黄体酮转化日子宫内膜厚度、临床妊娠率、生化妊娠率、早期流产率比较差异无统计学意义。结论对于薄型子宫患者,三种内膜准备方案的妊娠结局差异无明显统计学意义。
Objective To study the thin endometrium in patients with three different solutions to the freezing and thawing embryo transfer cycle after the lining of the clinical treatment outcome, on patients with the suitable method of freezing and thawing embryo transfer. Methods Select accept the freeze-thaw embryos thawing and cooperation in our hospital patients with transplant period, always repeated lining thickness monitoring is not more than 7 mm, willingness to patients are divided into: 1 group USES the natural cycle, two groups using induced ovulation cycle.Results The three groups using hormone replacement cycle for thin endometrium patients, three groups of progesterone into day palace film thickness biochemical pregnancy rate of clinical pregnancy rate of early abortion rate had no statistical difference. Conclusion There was no statistically significant difference in pregnancy outcome between the three endometrial preparation regimens in patients with thin uterus.
Objective To study the thin endometrium in patients with three different solutions to the freezing and thawing embryo transfer cycle after the lining of the clinical treatment outcome, on patients with the suitable method of freezing and thawing embryo transfer. Methods Select accept the freeze-thaw embryos thawing and cooperation in our hospital patients with transplant period, always repeated lining thickness monitoring is not more than 7 mm, willingness to patients are divided into: 1 group USES the natural cycle, two groups using induced ovulation cycle.Results The three groups using hormone replacement cycle for thin endometrium patients, three groups of progesterone into day palace film thickness biochemical pregnancy rate of clinical pregnancy rate of early abortion rate had no statistical difference. Conclusion There was no statistically significant difference in pregnancy outcome between the three endometrial preparation regimens in patients with thin uterus.
引文
[1] McWilliams GD, Frattarelli JL. Changes in measured endometrial thickness predict in vitro fertilization Success[J]. Fertil Steril, 2007,88(1):74-81.
[2] Gleieher N, Vidali A, Barad DH. Suceessful treatment of unresponsi-thin endometriumⅢ[J]. Fenil Steril, 2O11,95(6):2l23,e13-e17.
[3] Miwa I, Tamura H, Takasaki A, et a1. Pathophysi0l0gic lea tures of"thin"endometrium[J]. Fertil Steril, 2009,91(4):998-1004.
[4] Casper RF. It's time to pay attention to the endometrium[J]. Fertil Steril, 2011,96(3):519-521.
[5] Davar R, Dehqhani Firouzabadi R, Chaman Ara K. Dilatation and curettage effect on the endometrial thickness[J]. Iran Red Crescent Med J, 2O13, 15(4):350-355.
[6] Okogbo FO, Ezechi OC, Loto OM, et a1. Uterine Leiomyomata in South Western Nigeria:a clinical study of presentations and management outcome[J]. Afr Health Sei, 2011,l1(2):271-278.
[7] Talukdar N, Bentov Y,Chang PT, et a1. Effect of longterm combined oral contraceptive pill use on endometrial thickness[J]. Ohstet Gynecol, 2012, 120(2 Pt1):348-354.
[8] Jimenez PT, Schon SB, Odem RR, et a1. A retrospective cross—sectional study:fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles[J]. Reprod Biol Endocrinol, 2013(11):35.
[9] Gonzalez Gonzalez NL, Gonzalez Davila E, Castro A, et a1. Effect of pregestational diabetes mellitus on first trimester placental characteristics:three—dimensional placental volume and power Doppler indices[J]. Placenta, 2014,35(3):147-151.
[10] Al-Ghamdi A, Coskun S, A1-Hassan S, et a1.The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer(IVFET)outcome[J]. Reprod Biol Endocrinol, 2008(6):37.
[11]陈芳.不同水平雌激素在宫腔粘连形成中的作用及相关机制[J].中华妇产科杂志,2010,45(12):917-920.
[12]高敏芝,辛梅珍,赵晓明,等.控制性超促排卵对黄体期子宫内膜胶原纤维表达的影响[J].生殖与避孕,2010,30(10):668-674.
[13]洪宇,陈冬梅,李扬志,等,整合素αγβ3和孕激素受体在子宫内膜异位症患者黄体中期子宫内膜中的表达[J].中国妇幼保健,2012,27(13):2024-2027
[14]李贺梅,靳镭.IVF/ICSI中异位妊娠发生的危险因素分析[J].中国优生与遗传杂志,2010,18(11):118-120.
[2] Gleieher N, Vidali A, Barad DH. Suceessful treatment of unresponsi-thin endometriumⅢ[J]. Fenil Steril, 2O11,95(6):2l23,e13-e17.
[3] Miwa I, Tamura H, Takasaki A, et a1. Pathophysi0l0gic lea tures of"thin"endometrium[J]. Fertil Steril, 2009,91(4):998-1004.
[4] Casper RF. It's time to pay attention to the endometrium[J]. Fertil Steril, 2011,96(3):519-521.
[5] Davar R, Dehqhani Firouzabadi R, Chaman Ara K. Dilatation and curettage effect on the endometrial thickness[J]. Iran Red Crescent Med J, 2O13, 15(4):350-355.
[6] Okogbo FO, Ezechi OC, Loto OM, et a1. Uterine Leiomyomata in South Western Nigeria:a clinical study of presentations and management outcome[J]. Afr Health Sei, 2011,l1(2):271-278.
[7] Talukdar N, Bentov Y,Chang PT, et a1. Effect of longterm combined oral contraceptive pill use on endometrial thickness[J]. Ohstet Gynecol, 2012, 120(2 Pt1):348-354.
[8] Jimenez PT, Schon SB, Odem RR, et a1. A retrospective cross—sectional study:fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles[J]. Reprod Biol Endocrinol, 2013(11):35.
[9] Gonzalez Gonzalez NL, Gonzalez Davila E, Castro A, et a1. Effect of pregestational diabetes mellitus on first trimester placental characteristics:three—dimensional placental volume and power Doppler indices[J]. Placenta, 2014,35(3):147-151.
[10] Al-Ghamdi A, Coskun S, A1-Hassan S, et a1.The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer(IVFET)outcome[J]. Reprod Biol Endocrinol, 2008(6):37.
[11]陈芳.不同水平雌激素在宫腔粘连形成中的作用及相关机制[J].中华妇产科杂志,2010,45(12):917-920.
[12]高敏芝,辛梅珍,赵晓明,等.控制性超促排卵对黄体期子宫内膜胶原纤维表达的影响[J].生殖与避孕,2010,30(10):668-674.
[13]洪宇,陈冬梅,李扬志,等,整合素αγβ3和孕激素受体在子宫内膜异位症患者黄体中期子宫内膜中的表达[J].中国妇幼保健,2012,27(13):2024-2027
[14]李贺梅,靳镭.IVF/ICSI中异位妊娠发生的危险因素分析[J].中国优生与遗传杂志,2010,18(11):118-120.