牛磺酸消炎抗氧化机理及其在幼龄动物中的应用
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摘要
牛磺酸广泛存在于动物组织细胞内,具有消炎抗氧化生物学功能。目前研究发现牛磺酸消炎抗氧化机理包括:通过雷帕霉素靶蛋白(m TOR)信号通路促进肠黏膜修复,通过抑制Toll样受体4(TLR4)信号通路缓解肠黏膜炎症反应,通过瞬时受体电位通道M2(TRPM2)离子通道改善细胞线粒体生理功能。本文就牛磺酸消炎抗氧化机理以及在幼龄动物中的应用进行综述,以期为牛磺酸在消炎抗氧化方面研究提供参考意义。
Taurine is widely found in the cells of animal tissues and has anti-inflammatory and antioxidant biological function. Recent studies have found that anti-inflammatory and anti-oxidative mechanism of taurine is as follows: taurine promotes the repair of intestinal mucosa through mammalian target of rapamyein( m TOR) signaling pathway; taurine alleviates the inflammatory reaction of intestinal mucosa by inhibiting Toll-like-receptors( TLR4) signaling pathway; taurine improves mitochondrial function in cell physiology through the transient receptor potential melastatin type 2( TRPM2) ion channels. In order to provide reference significance for taurine in anti-inflammatory and anti-oxidative research,the anti-inflammatory and anti-oxidative mechanism of taurine and the application of taurine in the young animals were reviewed in this paper.
Taurine is widely found in the cells of animal tissues and has anti-inflammatory and antioxidant biological function. Recent studies have found that anti-inflammatory and anti-oxidative mechanism of taurine is as follows: taurine promotes the repair of intestinal mucosa through mammalian target of rapamyein( m TOR) signaling pathway; taurine alleviates the inflammatory reaction of intestinal mucosa by inhibiting Toll-like-receptors( TLR4) signaling pathway; taurine improves mitochondrial function in cell physiology through the transient receptor potential melastatin type 2( TRPM2) ion channels. In order to provide reference significance for taurine in anti-inflammatory and anti-oxidative research,the anti-inflammatory and anti-oxidative mechanism of taurine and the application of taurine in the young animals were reviewed in this paper.
引文
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[19]HECQUET C M,AHMMED G U,VOGEL S M,et al.Role of TRPM2 channel in mediating H2O2-induced Ca2+entry and endothelial hyperpermeability[J].Circulation Research,2008,102(3):347-355.
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[23]NIR I,NITSAN Z,MAHAGNA M.Comparative grow th and development of the digestive organs and of some enzymes in broiler and egg type chicks after hatching[J].British Poultry Science,1998,34(3):523-532.
[24]ZENG D S,GAO Z H,HUANG X L,et al.Effect of taurine on lipid metabolism of broilers[J].Journal of Applied Animal Research,2012,40(2):86-89.
[25]YUAN J M,WANG Z H.Effect of taurine on intestinal morphology and utilisation of soy oil in chickens[J].British Poultry Science,2010,51(4):540-545.
[26]SHIM K S,JUNG H J,NA C S,et al.Effects of taurine on lipid metabolism and protein synthesis in poultry and mice[J].Asian-Australasian Journal of Animal Sciences,2009,22(6):865-870.
[27]SATSU H,KOBAYASHI Y,YOKOYAMA T,et al.Effect of dietary sulfur amino acids on the taurine content of rat tissues[J].Amino Acids,2002,23(4):447-452.
[28]HUANG C X,WANG B,MIN Z,et al.Dietary inclusion level and time effects of taurine on broiler performance,meat quality,oxidative status and muscle taurine content[J].British Poultry Science,2014,55(5):598-604.
[29]李丽娟,王安,王鹏.牛磺酸对爱拔益加肉雏鸡生长性能及抗氧化功能的影响[J].动物营养学报,2010,22(3):696-701.
[30]田莉莉,李林.牛磺酸对肉仔鸡抗氧化能力的影响[J].饲料研究,2012(2):75-76.
[31]李万军.牛磺酸对肉鸡饲粮养分利用率、免疫器官发育及屠宰性能的影响研究[J].中国农学通报,2012,28(23):6-10.
[32]WANG F R,DONG X F,TONG J M,et al.Effects of dietary taurine supplementation on grow th performance and immune status in grow ing Japanese quail(Coturnix coturnix japonica)[J].Poultry Science,2009,88(7):1394-1398.
[33]杨小然,王安,郭志杰.牛磺酸对笼养蛋雏鸭生长性能、抗氧化功能及免疫器官发育的影响[J].动物营养学报,2011,23(5):807-812.
[34]于洋洋,陈涛,邱淑敏,等.牛磺酸对MDCC-MSB1细胞端粒酶表达水平及其活性的影响[J].饲料工业,2014,35(5):17-19.
[35]张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪肠道吸收功能的影响[J].中国畜牧兽医,2010,37(8):20-22.
[36]LIU Y,MAO X B,YU B,et al.Excessive dietary taurine supplementation reduces grow th performance,liver and intestinal health of w eaned pigs[J].Livestock Science,2014,168:109-119.
[2]SCHULLER-LEVIS G B,PARK E.Taurine:new implications for an old amino acid[J].FEM S M icrobiology Letters,2003,226(2):195-202.
[3]BLAIR R,JACOB J P,GARDINER E E.Lack of an effect of taurine supplementation on the incidence of sudden death syndrome in male broiler chicks[J].Poultry Science,1991,70(3):554-560.
[4]徐晓峰,张力莉.牛磺酸在动物营养中的应用研究进展[J].饲料与畜牧,2007(4):31-33.
[5]SMITH F,CLARK J E,OVERMAN B L,et al.Early w eaning stress impairs development of mucosal barrier function in the porcine intestine[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2010,298(3):G352-G363.
[6]ROY A,MANNA P,SIL P C.Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via M APKs/NF-κB and mitochondria dependent pathw ays[J].Free Radical Research,2009,43(10):995-1007.
[7]KONTNY E,SZCZEPANSKA K,KOWALCZEWSKI J,et al.The mechanism of taurine chloramine inhibition of cytokine(interleukin-6,interleukin-8)production by rheumatoid arthritis fibroblast-like synoviocytes[J].Arthritis&Rheumatism,2000,43(10):2169-2177.
[8]BARUA M,LIU Y,QUINN M R.Taurine chloramine inhibits inducible nitric oxide synthase and TNF-αgene expression in activated alveolar macrophages:decreased NF-κB activation and IκB kinase activity[J].The Journal of Immunology,2002,167(4):2275-2281.
[9]ROGLER G,BRAND K,VOGL D,et al.Nuclear factorκB is activated in macrophages and epithelial cells of inflamed intestinal mucosa[J].Gastroenterology,1998,115(2):357-369.
[10]GITTER A H,BENDFELDT K,SCHULZKE J D,et al.Leaks in the epithelial barrier caused by spontaneous and TNF-α-induced single-cell apoptosis[J].The Journal of the Federation of American Societies for Experimental Biology,2000,14(12):1749-1753.
[11]SCHREIBER S,NIKOLAUS S,HAMPE J.Activation of nuclear factorκB in inflammatory bow el disease[J].Gut,1998,42(4):477-484.
[12]THIELE K,BIERHAUS A,AUTSCHBACH F,et al.Cell specific effects of glucocorticoid treatment on the NF-κBp65/IκBαsystem in patients w ith Crohn’s disease[J].Gut,1999,45(5):693-704.
[13]XU Y,JAGANNATH C,LIU X D,et al.Toll-like receptor 4 is a sensor for autophagy associated w ith innate immunity[J].Immunity,2007,27(1):135-144.
[14]AKIRA S.Mammalian Toll-like receptors[J].Current Opinion in Immunology,2003,15(1):5-11.
[15]JOBIN C,HOLT L,BRADHAM C A,et al.TNF receptor-associated factor-2 is involved in both IL-1βand TNF-αsignaling cascades leading to NF-κB activation and IL-8 expression in human intestinal epithelial cells[J].The Journal of Immunology,1999,162(8):4447-4454.
[16]HENZE K,MARTIN W.Evolutionary biology:essence of mitochondria[J].Nature,2003,426(6963):127-128.
[17]汪朝晖,张贤康,缪明永,等.牛磺酸在大鼠缺血再灌注过程中对肝线粒体的保护作用[J].中西医结合肝病杂志,2002,12(6):351-354,357.
[18]马思聪,李磊,李海燕,等.瞬时受体电位2通道介导动物氧化应激的机理及其营养调控[J]动物营养学报,2013,25(10):2231-2237.
[19]HECQUET C M,AHMMED G U,VOGEL S M,et al.Role of TRPM2 channel in mediating H2O2-induced Ca2+entry and endothelial hyperpermeability[J].Circulation Research,2008,102(3):347-355.
[20]曾得寿,高振华,赵京辉,等.牛磺酸对肉仔鸡生产性能、免疫器官发育及抗氧化能力的影响[J].中国兽医学报,2009,29(6):774-778.
[21]黄春喜,袁建敏,周淑亮,等.牛磺酸对肉仔鸡生长性能、消化器官和免疫器官发育的影响[J].动物营养学报,2011,23(5):854-861.
[22]刘玉芝,刘艳琴.牛磺酸对肉仔鸡生产性能和免疫功能的影响[J].扬州大学学报:农业与生命科学版,2008,29(4):45-48.
[23]NIR I,NITSAN Z,MAHAGNA M.Comparative grow th and development of the digestive organs and of some enzymes in broiler and egg type chicks after hatching[J].British Poultry Science,1998,34(3):523-532.
[24]ZENG D S,GAO Z H,HUANG X L,et al.Effect of taurine on lipid metabolism of broilers[J].Journal of Applied Animal Research,2012,40(2):86-89.
[25]YUAN J M,WANG Z H.Effect of taurine on intestinal morphology and utilisation of soy oil in chickens[J].British Poultry Science,2010,51(4):540-545.
[26]SHIM K S,JUNG H J,NA C S,et al.Effects of taurine on lipid metabolism and protein synthesis in poultry and mice[J].Asian-Australasian Journal of Animal Sciences,2009,22(6):865-870.
[27]SATSU H,KOBAYASHI Y,YOKOYAMA T,et al.Effect of dietary sulfur amino acids on the taurine content of rat tissues[J].Amino Acids,2002,23(4):447-452.
[28]HUANG C X,WANG B,MIN Z,et al.Dietary inclusion level and time effects of taurine on broiler performance,meat quality,oxidative status and muscle taurine content[J].British Poultry Science,2014,55(5):598-604.
[29]李丽娟,王安,王鹏.牛磺酸对爱拔益加肉雏鸡生长性能及抗氧化功能的影响[J].动物营养学报,2010,22(3):696-701.
[30]田莉莉,李林.牛磺酸对肉仔鸡抗氧化能力的影响[J].饲料研究,2012(2):75-76.
[31]李万军.牛磺酸对肉鸡饲粮养分利用率、免疫器官发育及屠宰性能的影响研究[J].中国农学通报,2012,28(23):6-10.
[32]WANG F R,DONG X F,TONG J M,et al.Effects of dietary taurine supplementation on grow th performance and immune status in grow ing Japanese quail(Coturnix coturnix japonica)[J].Poultry Science,2009,88(7):1394-1398.
[33]杨小然,王安,郭志杰.牛磺酸对笼养蛋雏鸭生长性能、抗氧化功能及免疫器官发育的影响[J].动物营养学报,2011,23(5):807-812.
[34]于洋洋,陈涛,邱淑敏,等.牛磺酸对MDCC-MSB1细胞端粒酶表达水平及其活性的影响[J].饲料工业,2014,35(5):17-19.
[35]张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪肠道吸收功能的影响[J].中国畜牧兽医,2010,37(8):20-22.
[36]LIU Y,MAO X B,YU B,et al.Excessive dietary taurine supplementation reduces grow th performance,liver and intestinal health of w eaned pigs[J].Livestock Science,2014,168:109-119.