长链非编码RNA在银屑病中的研究进展
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摘要
长链非编码RNA(lncRNA)是一类长度大于200个核苷酸的不具有蛋白编码功能的RNA,广泛存在于动植物中,在调控细胞周期、细胞分化、免疫反应等众多生命活动中发挥重要作用。最近的研究发现,lncRNA在银屑病患者皮损组织中异常表达,在银屑病发生、发展中发挥着重要调控作用。本文就lncRNA的概况及其在银屑病中的研究进展作一综述。
引文
[1] BORSANI G,TONLORENZI R,SIMMLER M C,et al.Characterization of a murine gene expressed from the inactive Xchromosome[J].Nature,1991,351(6324):325-329.
[2] KOPP F,MENDELL J T.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407.
[3] LI X,LI N.LncRNAs on guard[J].Int Immunopharmacol,2018,65:60-63.
[4] HUANG W,THOMAS B,FLYNN R A,et al.DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions[J].Nature,2015,528(7583):517-522.
[5] HU G,GONG A Y,WANG Y,et al.LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling[J].J Immunol,2016,196(6):2779-2808.
[6] SONKOLY E,BATA-CSORGO Z,PIVARCSI A,et al.Identification and characterization of a novel,psoriasis susceptibility-related noncoding RNA gene,PRINS[J].J Biol Chem,2005,280(25):24159-24167.
[7] SZEGEDI K,SONKOLY E,NAGY N,et al.The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA,PRINS[J].Exp Dermatol,2010,19(3):269-278.
[8] SZéLL M,DANIS J,BATA-CS?RGO Z,et al.PRINS,a primate-specific long non-coding RNA,plays a role in the keratinocyte stress response and psoriasis pathogenesis[J].Pflugers Arch,2016,468(6):935-943.
[9] DANIS J,GOBL?S A,BATA-CSORGO Z,et al.PRINS non-coding RNA regulates nucleic acid-induced innate immune responses of human keratinocytes[J].Front Immunol,2017,8:1053.
[10] TSOI L C,IYER M K,STUART P E,et al.Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin[J].Genome Biol,2015,16:24.
[11] GAO J,CHEN F,HUA M,et al.Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes[J].Biol Res,2018,51(1):30.
[12] QIAO M,LI R,ZHAO X,et al.Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7[J].Exp Cell Res,2018,363(2):243-254.
[13] LI C X,LI H G,HUANG L T,et al.H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p[J].Cell Death Dis,2017,8(11):e3174.
[14] HOLM S J,SáNCHEZ F,CARLéN L M,et al.HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3[J].Acta Derm Venereol,2005,85(1):2-8.
[15] CHANG Y T,CHOU C T,SHIAO Y M,et al.Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes[J].Br J Dermatol,2006,155(4):663-669.
[16] WI■NIEWSKI A,MATUSIAK L,SZCZERKOWSKA-DOBOSZ A,et al.HLA-C*06:02-independent,gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis[J].Mol Genet Genomics,2018,293(4):957-966.
[17] AHN R,GUPTA R,LAI K,et al.Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs[J].BMC Genomics,2016,17(1):841.
[18] KRETZ M,SIPRASHVILI Z,CHU C,et al.Control of somatic tissue differentiation by the long non-coding RNA TINCR[J].Nature,2013,493(7431):231-235.
[19] 王靖,张新萍,金虹,等.长链非编码RNA作为竞争性内源RNA调控银屑病发展的机制研究[J].中华生物医学工程杂志,2018,24(2):77-84.
[20] DOLCINO M,PELOSI A,FIORE P F,et al.Long non-coding RNAs play a role in the pathogenesis of psoriatic arthritis by regulating microRNAs and genes involved in inflammation and metabolic syndrome[J].Front Immunol,2018,9:1533.
[21] 乔锰.长链非编码RNA-MSX2P1通过miR-6731-5p对S100A7的调控在银屑病发病中的作用[D].济南:山东大学,2018:169.
[2] KOPP F,MENDELL J T.Functional classification and experimental dissection of long noncoding RNAs[J].Cell,2018,172(3):393-407.
[3] LI X,LI N.LncRNAs on guard[J].Int Immunopharmacol,2018,65:60-63.
[4] HUANG W,THOMAS B,FLYNN R A,et al.DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions[J].Nature,2015,528(7583):517-522.
[5] HU G,GONG A Y,WANG Y,et al.LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling[J].J Immunol,2016,196(6):2779-2808.
[6] SONKOLY E,BATA-CSORGO Z,PIVARCSI A,et al.Identification and characterization of a novel,psoriasis susceptibility-related noncoding RNA gene,PRINS[J].J Biol Chem,2005,280(25):24159-24167.
[7] SZEGEDI K,SONKOLY E,NAGY N,et al.The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA,PRINS[J].Exp Dermatol,2010,19(3):269-278.
[8] SZéLL M,DANIS J,BATA-CS?RGO Z,et al.PRINS,a primate-specific long non-coding RNA,plays a role in the keratinocyte stress response and psoriasis pathogenesis[J].Pflugers Arch,2016,468(6):935-943.
[9] DANIS J,GOBL?S A,BATA-CSORGO Z,et al.PRINS non-coding RNA regulates nucleic acid-induced innate immune responses of human keratinocytes[J].Front Immunol,2017,8:1053.
[10] TSOI L C,IYER M K,STUART P E,et al.Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin[J].Genome Biol,2015,16:24.
[11] GAO J,CHEN F,HUA M,et al.Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes[J].Biol Res,2018,51(1):30.
[12] QIAO M,LI R,ZHAO X,et al.Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7[J].Exp Cell Res,2018,363(2):243-254.
[13] LI C X,LI H G,HUANG L T,et al.H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p[J].Cell Death Dis,2017,8(11):e3174.
[14] HOLM S J,SáNCHEZ F,CARLéN L M,et al.HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3[J].Acta Derm Venereol,2005,85(1):2-8.
[15] CHANG Y T,CHOU C T,SHIAO Y M,et al.Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes[J].Br J Dermatol,2006,155(4):663-669.
[16] WI■NIEWSKI A,MATUSIAK L,SZCZERKOWSKA-DOBOSZ A,et al.HLA-C*06:02-independent,gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis[J].Mol Genet Genomics,2018,293(4):957-966.
[17] AHN R,GUPTA R,LAI K,et al.Network analysis of psoriasis reveals biological pathways and roles for coding and long non-coding RNAs[J].BMC Genomics,2016,17(1):841.
[18] KRETZ M,SIPRASHVILI Z,CHU C,et al.Control of somatic tissue differentiation by the long non-coding RNA TINCR[J].Nature,2013,493(7431):231-235.
[19] 王靖,张新萍,金虹,等.长链非编码RNA作为竞争性内源RNA调控银屑病发展的机制研究[J].中华生物医学工程杂志,2018,24(2):77-84.
[20] DOLCINO M,PELOSI A,FIORE P F,et al.Long non-coding RNAs play a role in the pathogenesis of psoriatic arthritis by regulating microRNAs and genes involved in inflammation and metabolic syndrome[J].Front Immunol,2018,9:1533.
[21] 乔锰.长链非编码RNA-MSX2P1通过miR-6731-5p对S100A7的调控在银屑病发病中的作用[D].济南:山东大学,2018:169.