搜索页_+Poorly+water-soluble+drug

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(5)	SpringerLink电子期刊(329)	Elsevier电子期刊(984)
Springer电子图书(15)	NATURE电子期刊(2)	ACS电子期刊(137)

在“Elsevier电子期刊”中，命中：984条，耗时：0.0949837 秒

在所有数据库中总计命中：1,472条

1.Synergistic role of solid lipid and porous silica in improving the oral delivery of weakly basic poorly water soluble drugs

作者：Rokhsana Yasmin ; Shasha Rao ; Kristen Bremmell ; Clive Prestidge ; ^{Clive.Prestidge@unisa.edu.au}

关键词：Oral delivery ; Poorly water soluble drugs ; Solid lipid ; Porous silica ; Solubilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Critical Material Attributes of Strip Films Loaded With Poorly Water-Soluble Drug Nanoparticles: II. Impact of Polymer Molecular Weight

作者：Scott M. Krull ; Jennifer Ammirata ; Sonia Bawa ; Meng Li ; Ecevit Bilgili ; Rajesh N. Davé ; ; ^{dave@njit.edu}

关键词：biodegradable polymers ; content uniformity ; controlled release/delivery ; dissolution rate ; formulation ; nanoparticles ; particle sizing ; polymeric drug delivery systems ; thermogravimetric analysis ; UV/vis spectroscopy

刊名：Journal of Pharmaceutical Sciences

出版年：2017

3.Modified mesoporous silica nanoparticles for enhancing oral bioavailability and antihypertensive activity of poorly water soluble valsartan

作者：Nikhil Biswas ^{nikhil_ju05@yahoo.co.in} ^{nikhilju05@gmail.com}

关键词：Poorly water soluble drug ; Mesoporous silica nanoparticles ; Functionalization ; Bioavailability ; In vitro in vivo correlation ; Antihypertensive activity

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

4.Carrier particle design for stabilization and isolation of drug nanoparticles

作者：Teresa Tierney ^{Teresa.Tierney@ul.ie} ; Katalin Bodná ; r ^{Katalin.Bodnar@ul.ie} ; Å ; ke Rasmuson ^{Ake.Rasmuson@ul.ie} ; Sarah Hudson ; ^{Sarah.Hudson@ul.ie}

关键词：Carrier particles ; Drug nanoparticles ; Bioavailability ; Antisolvent precipitation ; Filtration ; Dissolution rate

刊名：International Journal of Pharmaceutics

出版年：2017

5.Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant

作者：Pengli Bu^a ; ^b ; Yue Ji^b ; Silpa Narayanan^a ; Damon Dalrymple^c ; Xingguo Cheng^a ; Abu T.M. Serajuddin^a ; ^{serajuda@stjohns.edu}

关键词：LBDDS ; lipid-based drug delivery system ; LBSEDDS ; lipid-based self-emulsifying drug delivery system ; SEDDS ; self-emulsifying drug delivery system ; SMEDDS ; self-microemulsifying drug delivery system ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; PG ; propylene glycol ; HBSS ; Hank's Balanced Salt Solution ; DMEM ; Dulbecco's Modification of Eagle's Medium ; FBS ; fetal bovine serum ; DMSO ; dimethyl sulfoxide ; TEER ; transepithelial electrical resistance

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

6.Design of PVP/VA S-630 based tadalafil solid dispersion to enhance the dissolution rate

作者：Jin-Seok Choi ; Jeong-Sook Park ; ^{eicosa@cnu.ac.kr}

关键词：TDF ; Tadalafil ; SD ; Solid dispersion ; DW ; Distilled water ; FE-SEM ; Field emission scanning electron microscope ; DSC ; Differential scanning calorimetry ; PXRD ; Powder X-ray diffraction ; SLS ; Sodium lauryl sulfate

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

7.In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells

作者：Patrí ; cia Figueiredo^a ; ^{patricia.figueiredo@helsinki.fi} ; Kalle Lintinen^b ; Alexandros Kiriazis^a ; Ville Hynninen^c ; Zehua Liu^a ; Tomá ; s Bauleth-Ramos^a ; ^d ; ^e ; ^f ; Antti Rahikkala^a ; Alexandra Correia^a ; Tomá ; &scaron ; Kohout^g ; Bruno Sarmento^d ; ^e ; ^f ; Jari Yli-Kauhaluoma^a ; Jouni Hirvonen^a ; Olli Ikkala^c ; Mauri A. Kostiainen^b ; Hé ; lder A. Santos^a ; ^{helder.santos@helsinki.fi}

关键词：Lignin nanoparticles ; Biocompatibility ; Cellular uptake ; Drug loading ; Benzazulene ; Antiproliferation effect

刊名：Biomaterials

出版年：2017

8.Poly(ε-benzyloxycarbonyl-L-lysine)-grafted branched polyethylenimine as efficient nanocarriers for indomethacin with enhanced oral bioavailability and anti-inflammatory efficacy

作者：Chao Lu¹ ; Xin Li¹ ; Wenquan Xia ; Siheng Lu ; Hongjun Luo ; Danyan Ye ; Yanmei Zhang ; Daojun Liu ; ^{liudj@stu.edu.cn}

关键词：Drug delivery ; Star-block copolymer ; Indomethacin ; Bioavailability ; Ischemia-reperfusion injury

刊名：Acta Biomaterialia

出版年：2017

9.Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells

作者：Kalle Sigfridsson^a ; ^{carl-gustav.sigfridsson@astrazeneca.com} ; Urban Skantze^a ; Pia Skantze^a ; Svante Johansson^a ; Iain Grant^b ; Bå ; rd Smedsrø ; d^c ; ^d ; Britt Fuglesteg^c ; Kjetil Elvevold^c ; Lennart Lindfors^a

关键词：Adsorption isotherm ; CMC ; Critical micelle concentration ; Liposomes ; Nanoparticles ; PEG ; Phospholipids ; Pluronic ; Poloxamer ; Stealth ; Zeta potential

刊名：International Journal of Pharmaceutics

出版年：2017

10.The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers

作者：Kristian Semjonov^a ; ^{kristian.semjonov@ut.ee} ; Karin Kogermann^a ; ^{karin.kogerman@ut.ee} ; Ivo Laidmä ; e^a ; ^{ivo.laidmae@ut.ee} ; Osmo Antikainen^b ; ^{osmo.antikainen@helsinki.fi} ; Clare J Strachan^b ; ^{clare.strachan@helsinki.fi} ; Henrik Ehlers^b ; ^{henrik.ehlers@helsinki.fi} ; Jouko Yliruusi^b ; ^{jouko.yliruusi@helsinki.fi} ; Jyrki Heinä ; mä ; ki^a ; ^{jyrki.heinamaki@ut.ee}

关键词：Solid dispersion ; Two-phase systems ; Supercooled molten mixture ; Indomethacin ; Soluplus® ; Xylitol ; Solid-state stability

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

按检索点细分(984)

题名(182)

关键词(146)

文摘(860)

按出版年细分(984)

2027年及以后(46)

2017年(19)

2016年(90)

2015年(23)

2013年(93)

2012年(84)

2011年(99)

2010年(73)

2009年(60)

2008年(63)

2007年(48)

2006年(37)

2005年(37)

2004年(44)

2003年(32)

2002年(22)

2001年(23)

2000年(13)

2000年及以前(78)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700