作者：Anita R. Iskandar^a ; ¹ ; ^{Anita.Iskandar@pmi.com} ; Carole Mathis^a ; ¹ ; ^{Carole.Mathis@pmi.com} ; Walter K. Schlage^b ; ^{WK.Schlage@t-online.de} ; Stefan Frentzel^a ; ^{Stefan.Frentzel@pmi.com} ; Patrice Leroy^a ; ^{Patrice.Leroy@pmi.com} ; Yang Xiang^a ; ^{Yang.Xiang@pmi.com} ; Alain Sewer^a ; ^{Alain.Sewer@pmi.com} ; Shoaib Majeed^a ; ^{Shoaib.Majeed@pmi.com} ; Laura Ortega-Torres^a ; ^{Laura.OrtegaTorres@pmi.com} ; Stephanie Johne^a ; ^{Stephanie.Johne@pmi.com} ; Emmanuel Guedj^a ; ^{Emmanuel.Guedj@pmi.com} ; Keyur Trivedi^a ; ^{Keyur.Trivedi@pmi.com} ; Gilles Kratzer^a ; ^{Gilles.Kratzer@gmail.com} ; Celine Merg^a ; ^{Celine.Merg@pmi.com} ; Ashraf Elamin^a ; ^{Ashraf.Elamin@pmi.com} ; Florian Martin^a ; ^{Florian.Martin@pmi.com} ; Nikolai V. Ivanov^a ; ^{Nikolai.Ivanov@pmi.com} ; Manuel C. Peitsch^a ; ^{Manuel.Peitsch@pmi.com} ; Julia Hoeng^a ; ^{Julia.Hoeng@pmi.com}

关键词：3D ; Three-dimensional ; AK ; Adenylate kinase ; BIF ; Biological impact factor ; CBF ; Ciliary beating frequency ; CCL ; Chemokine (C-C motif) ligand ; CFA ; Cell fate ; CPR ; Cell proliferation ; CS ; Cigarette smoke ; CST ; Cell stress ; CXCL ; Chemokine (C-X-C motif) ligand ; DEG ; Differentially expressed gene ; EGF ; Epidermal growth factor ; FDR ; False discovery rate ; FFT ; Fast Fourier transformation ; H&E ; Hematoxylin and eosin ; IL ; Interleukin ; IPN ; Inflammatory process networks ; MiRNA ; microRNA ; MMP ; Matrix me

刊名：Toxicology in Vitro

出版年：2017

作者：Ee Tsin Wong^a ; Ulrike Kogel^b ; Emilija Veljkovic^a ; Florian Martin^b ; Yang Xiang^b ; Stephanie Boue^b ; Gregory Vuillaume^b ; Patrice Leroy^b ; Emmanuel Guedj^b ; Gregory Rodrigo^c ; Nikolai V. Ivanov^b ; Julia Hoeng^b ; Manuel C. Peitsch^b ; Patrick Vanscheeuwijck^b ; ^{Patrick.Vanscheeuwijck@pmi.com}

关键词：Heat-not-burn ; Modified risk tobacco product ; Pulmonary inflammation ; Inhalation toxicology study ; Inhalation systems toxicology

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Ulrike Kogel^a ; ¹ ; Bjoern Titz^a ; ¹ ; Walter K. Schlage^b ; Catherine Nury^a ; Florian Martin^a ; Alberto Oviedo^c ; Stefan Lebrun^a ; Ashraf Elamin^a ; Emmanuel Guedj^a ; Keyur Trivedi^a ; Nikolai V. Ivanov^a ; Patrick Vanscheeuwijck^a ; Manuel C. Peitsch^a ; Julia Hoeng^a ; ^{julia.hoeng@pmi.com}

关键词：Modified risk tobacco product ; Systems toxicology ; Transcriptomics ; Proteomics ; Lipidomics ; Subchronic inhalation toxicity

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Alexander Gosslau^a ; ^b ; ^{agosslau@bmcc.cuny.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Food toxicology ; Oxidative stress ; Inflammation ; In vitro ; in vivo and in silico models ; Alternative models

刊名：Food Science and Human Wellness

出版年：2016

作者：Paul Brownbill^a ; ^b ; ^{paul.brownbill@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Igor Chernyavsky^c ; ^{igor.chernyavsky@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Barbara Bottalico^d ; ^{barbarabottalico28@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Gernot Desoye^e ; ^{gernot.desoye@medunigraz.at" class="auth_mail" title="E-mail the corresponding author} ; Stefan Hansson^d ; ^{stefan.hansson@med.lu.se" class="auth_mail" title="E-mail the corresponding author} ; Gerry Kenna^f ; ^{gerry@safermedicines.org" class="auth_mail" title="E-mail the corresponding author} ; Lisbeth E. Knudsen^g ; ^{liek@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Udo R. Markert^h ; ^{udo.markert@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Nicola Powles-Gloverⁱ ; ^{Nicola.PowlesGlover@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Henning Schneider^j ; ^{henning.schneider@hispeed.ch" class="auth_mail" title="E-mail the corresponding author} ; Lopa Leach^k ; ^{Lopa.Leach@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：PlaNet ; placentology network ; HPTSs ; human placental test systems ; FDA ; Food and Drug Administration ; EMA ; European Medicines Agency ; PLLR ; pregnancy and lactation labelling rule ; IVS ; intervillous space ; HUVEC ; human umbilical vein endothelial cell ; NET ; norepinephrine transporter ; EMT ; extra-neural monoamine transporter ; VMAT2 ; vesicular monoamine transporter 2 ; NOAEL ; no observed adverse effect level ; LOAEL ; lowest observable adverse effect level ; DART ; development and reproductive toxicology

刊名：Reproductive Toxicology

出版年：2016

作者：Carine Poussin ; ^{Carine.Poussin@pmi.com" class="auth_mail" title="E-mail the corresponding author} ; Alexandra Laurent ; Manuel C. Peitsch ; Julia Hoeng ; Hector De Leon

关键词：CS ; cigarette smoke ; FDR ; false discovery rate ; HCAECs ; human coronary artery endothelial cells ; I ; D ; and FD ; indirect ; direct and fresh direct ; respectively ; ICAM-1 ; intercellular adhesion molecule 1 ; MM6 ; Mono Mac 6 ; MRTP ; modified risk tobacco product ; NPA ; network perturbation amplitude ; (R)BIF ; (Relative) biological impact factor ; SELE ; E-selectin ; SM ; starvation medium ; TACE ; tumor necrosis factor-α-converting enzyme ; THS2.2 ; Tobacco Heating System 2.2 ; TNFα ; tumor necrosis factor-alpha

刊名：Toxicology

出版年：2016

作者：Alberto Oviedo^b ; ¹ ; Stefan Lebrun^a ; ¹ ; Ulrike Kogel^a ; Jenny Ho^b ; Wei Teck Tan^b ; Bjoern Titz^a ; Patrice Leroy^a ; Gregory Vuillaume^a ; Monali Bera^c ; Florian Martin^a ; Gregory Rodrigo^c ; Marco Esposito^a ; Ruth Dempsey^a ; Nikolai V. Ivanov^a ; Julia Hoeng^a ; Manuel C. Peitsch^a ; Patrick Vanscheeuwijck^a ; ^{Patrick.vanscheeuwijck@pmi.com}

关键词：Inhalation ; Potential reduced risk product ; Heat-not-burn ; Pulmonary inflammation ; Toxicity ; Menthol

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Martin Roursgaard^a ; ^{mwro@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Kristina Bram Knudsen^a ; ^b ; ^c ; Helle Northeved^c ; Mikael Persson^c ; Tina Christensen^c ; Pramod E.K. Kumar^d ; Anders Permin^e ; Thomas L. Andresen^d ; Torben Gjetting^d ; Jens Lykkesfeldt^a ; Lise K. Vesterdal^a ; Steffen Loft^a ; Peter Mø ; ller^a

关键词：Drug delivery systems ; Liposomes ; Micelles ; In vitro toxicology ; Nanomedicine ; Hepatocytes ; Lung epithelial cells ; Comet assay

刊名：Toxicology in Vitro

出版年：2016

作者：Wolfgang Dekant^a ; ^{dekant@toxi.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author} ; James E. Klaunig^b ; ^{jklauni@indiana.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Reproductive toxicity ; Carcinogenicity ; Silicones ; Enzyme induction

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Mó ; nica J.B. Amorim^a ; ^{mjamorim@ua.pt" class="auth_mail" title="E-mail the corresponding author} ; Carlos P. Roca^c ; Janeck J. Scott-Fordsmand^b

关键词：High-throughput screening (HTS) ; High-effect screening (HES) ; High content analysis (HCA) ; Safety ; Systems toxicology ; Adverse outcome pathway (AOP) ; Biostatistics

刊名：Environmental Pollution

出版年：2016