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1.Adenosine A_2A and A_2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis

作者：Rosa M. André ; s¹ ; ² ; Marí ; a Carmen Terencio¹ ; ² ; Jorge Arasa¹ ; ² ; Miguel Payá ; ¹ ; ² ; Francisca Valcuende-Cavero³ ; ⁴ ; Pedro Navaló ; n⁵ ; Marí ; a Carmen Montesinos¹ ; ² ; ^{m.carmen.montesinos@uv.es}

关键词：AR ; adenosine receptors ; BAY ; BAY60&ndash ; 6583 ; CGS ; CGS-21680 ; iCa2+ ; intracellular calcium ; MRS ; MRS-1706 ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; NECA ; 5'-N-ethylcarboxamidoadenosine ; NHEK ; normal human epidermal keratinocyte ; SCH ; SCH-442416 ; TNF ; tumor necrosis factor ; TPA ; 12-O-tetradecanoylphorbol-13-acetate

刊名：Journal of Investigative Dermatology

出版年：2017

2.Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility

作者：Duncan Hieu M. Dam¹ ; ² ; Xiao-Qi Wang¹ ; ² ; Sarah Sheu¹ ; Mahima Vijay¹ ; Desmond Shipp¹ ; Luke Miller¹ ; Amy S. Paller¹ ; ^{apaller@northwestern.edu}

关键词：AS ; antisense oligonucleotide ; GCS ; glucosylceramide synthase ; GCSI ; glucosylceramide synthase inhibitor ; GM3S ; ganglioside GM3 synthase ; IGF-1 ; insulin-like growth factor-1 ; IGF1R ; insulin-like growth factor-1 receptor ; IR ; insulin receptor ; M2D3 ; GM2/GD2 and GD3 synthases ; NHEK ; normal human epidermal keratinocyte ; shRNA ; short hairpin RNA ; siRNA ; small interfering RNA ; SNA ; spherical nucleic acid

刊名：Journal of Investigative Dermatology

出版年：2017

3.Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes

作者：Michael R. Williams¹ ; Teruaki Nakatsuji¹ ; James A. Sanford¹ ; Alison F. Vrbanac¹ ; Richard L. Gallo¹ ; ^{rgallo@ucsd.edu}

关键词：AD ; atopic dermatitis ; DSG-1 ; desmoglein-1 ; FLG ; filaggrin ; KLK ; kallikrein ; MMP ; matrix metalloproteinase ; NHEK ; normal human epidermal keratinocyte ; Pro-FLG ; profilaggrin ; RT ; room temperature ; siRNA ; small interfering RNA ; TSB ; tryptic soy broth

刊名：Journal of Investigative Dermatology

出版年：2017

4.Allergy-Inducing Chromium Compounds Trigger Potent Innate Immune Stimulation Via ROS-Dependent Inflammasome Activation

作者：Christian Adam¹ ; Jonas Wohlfarth¹ ; Maike Hauß ; mann¹ ; Helga Sennefelder¹ ; Annette Rodin¹ ; Mareike Maler² ; Stefan F. Martin² ; Matthias Goebeler¹ ; Marc Schmidt¹ ; ^{schmidt_M11@ukw.de}

关键词：ATP ; adenosine triphosphate ; BMDC ; bone marrow-derived dendritic cell ; CrO42&ndash ; potassium chromate ; Cr2O72&ndash ; potassium dichromate ; Cr3+ ; chromium chloride ; chromium (III) ; trivalent chromium ; chromium (VI) ; hexavalent chromium ; DAMP ; damage-associated molecular pattern ; LDH ; lactate dehydrogenase ; LPS ; lipopolysaccharide ; NHEK ; normal human epidermal keratinocyte ; mROS ; mitochondrial reactive oxygen species ; TLR ; toll-like receptor ; TPA ; 12-O-tetradecanoylphorbol-13-acetate

刊名：Journal of Investigative Dermatology

出版年：2017

5.PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

作者：Susanne Grond¹ ; Thomas O. Eichmann¹ ; Sandrine Dubrac² ; Dagmar Kolb³ ; ⁴ ; ⁵ ; Matthias Schmuth² ; Judith Fischer⁶ ; Debra Crumrine⁷ ; Peter M. Elias⁷ ; Guenter Haemmerle¹ ; Rudolf Zechner¹ ; Achim Lass¹ ; Franz P.W. Radner¹ ; ^{franz.radner@uni-graz.at}

关键词：ABHD5 ; α/β hydrolase domain containing 5 ; ω-O-AcylCers ; ω-O-acylceramides ; ARCI ; autosomal recessive congenital ichthyosis ; CLE ; corneocyte-bound lipid envelope ; FA ; fatty acid ; ω-OH-(Glc)Cers ; ω-hydroxy-(glucosyl)ceramides ; PNPLA1 ; patatin-like phospholipase domain-containing 1 ; qRT-PCR ; quantitative real-time reverse transcriptase-PCR

刊名：Journal of Investigative Dermatology

出版年：2017

6.Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

作者：Xiannu Jin^a ; ^{xiannu.jin.ctr@mail.mil} ; Radharaman Ray^b ; Prabhati Ray^a

关键词：Sulfur mustard ; Serine protease ; Metalloprotease ; Protease inhibiter ; Zymography ; Laminin-5 γ2

刊名：Toxicology Reports

出版年：2016

7.Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress

作者：Annabell Plauth^a ; Anne Geikowski^a ; Susanne Cichon^a ; Sylvia J. Wowro^a ; Linda Liedgens^a ; Morten Rousseau^a ; Christopher Weidner^a ; Luise Fuhr^a ; Magdalena Kliem^a ; Gail Jenkins^b ; Silvina Lotito^b ; Linda J. Wainwright^b ; Sascha Sauer^a ; ^c ; ^d ; ^{sauer@molgen.mpg.de" class="auth_mail" title="E-mail the corresponding author}

关键词：RSV ; resveratrol (35 ; 4&prime ; -trihydroxy-trans-stilbene) ; SIRT1 ; sirtuin 1 ; PDE4 ; phosphodiesterase 4 ; ROS ; reactive oxygen species ; HNE ; 4-hydroxy-2-nonenal ; GSH ; glutathione ; KBM ; keratinocyte basal medium ; KGM ; keratinocyte growth medium ; NHEK ; neonatal normal human epidermal keratinocyte cells ; NHDF ; neonatal normal human dermal fibroblast cells ; NaHCO3 ; sodium bicarbonate

刊名：Free Radical Biology and Medicine

出版年：2016

8.Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions

关键词：HBD3 ; Human β-defensin 3 ; DCs ; dendritic cells ; NHEKs ; normal human epidermal keratinocytes ; hTERT ; human telomerase reverse transcriptase keratinocytes ; GE ; gingival epithelial keratinocytes ; PBMCs ; peripheral blood mononuclear cells ; PI ; propidium iodide ; MFI ; median fluorescence intensity ; LD50 ; lethal dose 50

刊名：Toxicology Letters

出版年：2015

9.Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium

作者：Karen L. Cooper^a ; Erica J. Dashner^a ; Ranalda Tsosie^b ; Young Mi Cho^c ; Johnnye Lewis^a ; ^d ; Laurie G. Hudson^a ; ^{lhudson@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; APTX ; aprataxin ; As ; arsenite ; CPDs ; cyclobutane pyrimidine dimers ; C ; cysteine ; DMEM ; Dulbecco's modified Eagle's medium ; H ; histidine ; HEK293 ; human embryonic kidney 293 ; ICP-MS ; inductively coupled plasma mass spectrometry ; HEKn ; normal human neonatal epidermal keratinocytes ; PBS ; phosphate-buffered saline ; pH2AX ; phospho-histone H2A.X ; PARP-1 ; poly(ADP-ribose) polymerase-1 ; SP-1 ; specificity protein-1 ; ssUVR ; solar-simulated ultraviolet radiation ; U

刊名：Toxicology and Applied Pharmacology

出版年：2016

10.Keratinocytes express functional CARD18, a negative regulator of inflammasome activation, and its altered expression in psoriasis may contribute to disease pathogenesis

作者：Anikó ; Gö ; blö ; s^a ; ^{goblos.aniko@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Judit Danis^a ; ^{danis.judit@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Krisztina Vas^a ; ^{vas.krisztina@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Zsuzsanna Bata-Csö ; rgő^a ; ^b ; ^{bata.zsuzsa@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Lajos Kemé ; ny^a ; ^b ; ^{kemeny.lajos@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author} ; Má ; rta Szé ; ll^b ; ^c ; ^{szell.marta@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：AIM2 ; absence in melanoma 2 ; CARD18 ; caspase recruitment domain family member 18 ; COP ; CARD-only protein ; DAPI ; 4 ; 6-diamidino-2-phenylindole ; DNase ; deoxyribonucleases ; GM-CSF ; granulocyte macrophage colony-stimulating factor ; IL ; interleukin ; IFN-ɣ ; interferon-ɣ ; TNF ; tumor necrosis factor ; IHC ; immunohistochemistry ; NHEK ; normal human epidermal keratinocytes ; PBS ; phosphate-buffered saline ; poly(dA ; dT) ; polydeoxyadenylic acid&ndash ; polydeoxythymidylic acid double-stranded homopolymer ; TS ; tape

刊名：Molecular Immunology

出版年：2016

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