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1.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

2.A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents

作者：Isabel Leung¹ ; ² ; Nick Jarvik² ; Sachdev S. Sidhu¹ ; ² ; ^{sachdev.sidhu@utoronto.ca}

关键词：Ubv ; ubiquitin variant ; Ub ; ubiquitin ; wt ; wild-type ; EGFR ; epidermal growth factor receptor ; EGF ; epidermal growth factor ; Her3 ; human epidermal growth factor receptor 3 ; NRG ; neuregulin ; Grb2 ; growth factor receptor-bound protein 2 ; GST ; glutathione S-transferase ; SPR ; surface plasmon resonance ; IP ; immunoprecipitation ; Grb2-SH2 ; Grb2 SH2 domain ; p-Tyr ; phospho-tyrosine ; pERK ; phosphorylated ERK ; pMEK ; phosphorylated MEK ; ERK ; extracellular signal-regulated kinase ; MEK ; MAPK/ERK kinase

刊名：Journal of Molecular Biology

出版年：2017

3.Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity

作者：Mikael Niku^a ; ^b ; ¹ ; Anne-Maria Pajari^a ; ¹ ; Laura Sarantaus^c ; Essi Pä ; ivä ; rinta^a ; Markus Storvik^d ; Anu Heiman-Lindh^a ; Santeri Suokas^b ; Minna Nyströ ; m^c ; Marja Mutanen^a ; ^{marja.mutanen@Helsinki.fi}

关键词：High-risk Western-type diet ; Intestinal cancer ; Energy metabolism ; Loss of heterozygosity ; PDK4 ; ERK ; ApcMin/+ mice

刊名：The Journal of Nutritional Biochemistry

出版年：2017

4.The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells

关键词：BM ; Basement Membrane ; CAM ; ChorioAllantoic Membrane ; CD ; Cytoplasmic Domain ; CD-44 ; Cluster of Differentiation 44 ; CM ; Conditioned Media ; ECM ; Extracellular Matrix ; ERK ; Extracellular Regulated Kinase ; F-actin ; Filamentous Actin ; FIH ; Factor Inhibiting HIF ; FL ; Full-Length ; HIF ; Hypoxia Inducible Factor ; MAPK ; Mitogen Activated Protein Kinase ; MMPs ; Matrix Metalloproteinases ; MMPi ; MMP inhibitor ; MT1/2-MMP ; Membrane Type 1/2 Matrix Metalloproteinase ; PH3 ; Phospho-Histone 3 ; TIMP-2 ; Tissue Inhib

刊名：Experimental Cell Research

出版年：2017

5.A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

作者：Jinqi Ren^a ; ¹ ; Aaron A. Cook^b ; ¹ ; Wolfgang Bergmeier^b ; John Sondek^a ; ^b ; ^c ; ^{sondek@med.unc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：RasGRP2 ; ERK1/2 signaling ; Negative-feedback loop ; Phosphorylation ; GEF ; CalDAG-GEFI

刊名：Biochemical and Biophysical Research Communications

出版年：2016

6.ERK activated by Histamine H1 receptor is anti-proliferative through spatial restriction in the cytosol

作者：Ruchi Jain ; Uchenna Watson ; Deepak Kumar Saini ; ^{deepak@mrdg.iisc.ernet.in}

关键词：GPCRs ; Transactivation ; ERK ; H1 receptor ; Live cell imaging ; FRAP

刊名：European Journal of Cell Biology

出版年：2016

7.Ginsenoside Rb1 Attenuates Acute Inflammatory Nociception by Inhibition of Neuronal ERK Phosphorylation by Regulation of the Nrf2 and NF-κB Pathways

作者：Minhee Jang^&lowast ; ; ^&dagger ; ; Min Jung Lee^&lowast ; ; ^&Dagger ; ; Jong Hee Choi^&lowast ; ; ^&Dagger ; ; Eun-Jeong Kim^&lowast ; ; ^&Dagger ; ; Seung-Yeol Nah^§ ; ; Hak-Jae Kim^¶ ; ; Sanghyun Lee^|| ; Sang Won Lee^&lowast ; &lowast ; ; Young Ock Kim^&lowast ; &lowast ; ; Ik-Hyun Cho^&lowast ; ; ^&Dagger ; ; ^&dagger ; &dagger ; ; ^{ihcho@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Ginsenoside-Rb1 ; intrathecal introduction ; inflammatory nociception ; phospho-ERK ; nuclear factor erythroid 2-related factor 2 ; nuclear factor-kappa B

刊名：The Journal of Pain

出版年：2016

8.Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

作者：Daniel A. Ritt¹ ; Marí ; a T. Abreu-Blanco² ; Lakshman Bindu² ; David E. Durrant¹ ; Ming Zhou² ; Suzanne I. Specht¹ ; Andrew G. Stephen² ; Matthew Holderfield² ; Deborah K. Morrison¹ ; ³ ; ^{morrisod@mail.nih.gov}

关键词：Ras pathway ; Sos ; Ras ; Raf ; ERK cascade ; JNK cascade ; phosphorylation ; rigosertib

刊名：Molecular Cell

出版年：2016

9.Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation

作者：Ying Guo^b ; Yuanyuan Ding^c ; Tao Zhang^c ; ^{taozhang@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Hongli An^a ; ^{anhongli@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Sinapine ; Doxorubicin ; MCF-7/dox ; P-glycoprotein ; NF-κB ; FGFR4

刊名：Phytomedicine

出版年：2016

10.Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo

作者：Yoko Yamagata^a ; ^b ; ^{yamagata@nips.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Angus C. Nairn^c ; ^d

关键词：anti-ERK1/2 ; anti-p44/42 MAPK antibody ; anti-phospho-ERK1/2 ; anti-phospho-p44/42 MAPK antibody ; CaMKII ; Ca2+/calmodulin-dependent protein kinase II ; ECT ; electroconvulsive treatment ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; GABAA-R ; γ-aminobutyric acid type A receptor ; KA ; kainic acid ; KA-SE ; kanic acid-induced status epileptcus ; MAPK ; mitogen-activated protein kinase ; MEK ; ERK kinase ; NMDA-R ; N-methyl-d-aspartate-type glutamate receptor ; PB ; phosphate buffer ; PBS ; phosphate buffered s

刊名：Brain Research

出版年：2015

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