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在“Elsevier”中，命中：1,742条，耗时：0.052936 秒

1.Sanger sequencing solved a cryptic case of severe alpha₁-antitrypsin deficiency

作者：Shing H. Zhan^a ; ^b ; Raja T. Abboud^a ; ^c ; Benjamin Jung^a ; ^d ; Brian Kuchinka^a ; ^e ; Diana Ralston^a ; ^d ; Brett Casey^a ; ^e ; Andre Mattman^a ; ^b ; ^{amattman@providencehealth.bc.ca}

关键词：AAT ; alpha1-antitrypsin deficiency ; AATD ; alpha1-antitrypsin deficiency ; COPD ; chronic obstructive pulmonary disease ; IEF ; isoelectric focusing ; PI ; protease inhibitor

刊名：Clinical Biochemistry

出版年：2012

2.Characterization of a novel weak interaction between MUC1 and Src-SH3 using nuclear magnetic resonance spectroscopy

作者：Nirosha Gunasekara^a ; Brian Sykes^b ; ^{brian.sykes@ualberta.ca} ; Judith Hugh^a ; ^{judithh@ualberta.ca}

关键词：ICAM-1 ; intercellular adhesion molecule-1 ; CD ; cytoplasmic domain ; SH3 ; Src homology-3 ; NMR ; nuclear magnetic resonance ; Kd ; dissociation constant ; 1H&ndash ; 15N HSQC NMR ; two-dimensional NMR spectra correlating the amide proton and nitrogen NMR chemical s

刊名：Biochemical and Biophysical Research Communications

出版年：2012

3.Diachronous evolution of the alpine continental subduction wedge: Evidence from P-T estimates in the Brian莽onnais Zone houill猫re (France - Western Alps)

作者：Pierre Lanari^a ; ^{pierre.lanari@ujf-grenoble.fr} ; Sté ; phane Guillot^a ; Sté ; phane Schwartz^a ; Olivier Vidal^a ; Pierre Tricart^a ; Nicolas Riel^a ; Olivier Beyssac^b

关键词：Continental subduction ; P&ndash ; T path ; Low-grade metamorphism ; Geodynamic ; Western Alps

刊名：Journal of Geodynamics

出版年：2012

4.Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

作者：Kenneth H. Huang^&dagger ; ; ^{khuang@pamlicopharma.com} ; Thomas E. Barta ; John W. Rice ; Emilie D. Smith ; Andy J. Ommen ; Wei Ma ; James M. Veal ; R. Patrick Fadden ; Amy F. Barabasz ; Briana E. Foley ; Philip F. Hughes ; Gunnar J. Hanson ; Christopher J. Markworth ; Melanie Silinski ; Jeffrey M. Partridge ; Paul M. Steed ; Steven E. Hall

关键词：Hsp90 ; Chaperone ; Inhibitors ; Indolone ; Aminoquinazoline ; Quinazoline ; Her2 ; Cancer

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

5.Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

作者：Petra Beli¹ ; ⁴ ; Natalia Lukashchuk² ; ⁴ ; Sebastian ; A. Wagner¹ ; Brian ; T. Weinert¹ ; Jesper ; V. Olsen¹ ; Linda Baskcomb² ; Matthias Mann¹ ; ³ ; ^{mmann@biochem.mpg.de} ; Stephen ; P. Jackson² ; ^{s.jackson@gurdon.cam.ac.uk} ; Chunaram Choudhary¹ ; ^{chuna.choudhary@cpr.ku.dk}

刊名：Molecular Cell

出版年：2012

6.Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: Results of a randomized, controlled trial

作者：David W. Scheifele^a ; ^{dscheifele@cw.bc.ca} ; ^{dscheifele@cfri.ca} ; Brian J. Ward^b ; Marc Dionne^c ; Otto G. Vanderkooi^d ; Mark Loeb^e ; Brenda L. Coleman^f ; Yan Li^g ; PHAC/CIHR Influenza Research Network (PCIRN)^h

关键词：Influenza vaccine ; seasonal ; Influenza vaccine ; A/H1N1pdm09 pandemic ; Vaccine adjuvants

刊名：Vaccine

出版年：2012

7.Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: A PHAC/CIHR Influenza Research Network (PCIRN) study

作者：Joanne M. Langley^a ; ^{Joanne.Langley@dal.ca} ; David W. Scheifele^b ; ^{dscheifele@cfri.ca} ; Caroline Quach^c ; ^{caroline.quach@mcgill.ca} ; Otto G. Vanderkooi^d ; ^{otto.vanderkooi@calgaryhealthregion.ca} ; Brian Ward^c ; ^{brian.ward@mcgill.ca} ; Shelly McNeil^a ; ^{Shelly.McNeil@cdha.nshealth.ca} ; Simon Dobson^b ; ^{sdobson@cw.bc.ca} ; James D. Kellner^d ; ^{Jim.Kellner@calgaryhealthregion.ca} ; Susan Kuhn^d ; ^{Susan.Kuhn@calgaryhealthregion.ca} ; Tobias Kollman^b ; ^{tkollm@mac.com} ; Donna MacKinnon-Cameron^a ; ^{Donna.MacKinnon-Cameron@dal.ca} ; Bruce Smith^a ; ^{Bruce.smith@dal.ca} ; Yan Li^e ; ^{yan.l@phac-aspc.gc.ca} ; Scott A. Halperin^a ; ^{scott.halperin@dal.ca}

关键词：Trivalent seasonal inactivated influenza vaccine ; Pandemic vaccine ; Immunogenicity ; Reactogenicity

刊名：Vaccine

出版年：2012

8.Kilometre-scale palaeoescarpments as evidence for Cretaceous synsedimentary tectonics in the External Brian莽onnais Domain (Ligurian Alps, Italy)

作者：Carlo Bertok^a ; ^{carlo.bertok@unito.it} ; Luca Martire^a ; Elena Perotti^a ; Anna d'Atri^a ; Fabrizio Piana^b

关键词：Palaeoescarpments ; Breccias ; External Brianç ; onnais ; Ligurian Alps ; Syn-depositional faults ; Cretaceous transtensional tectonics

刊名：Sedimentary Geology

出版年：2012

9.Carboniferous and Cretaceous mafic-ultramafic massifs in Inner Mongolia (China): A SHRIMP zircon and geochemical study of the previously presumed integral 鈥淗egenshan ophiolite鈥?/span>

作者：Ping Jian^a ; ^{jianping_510@yahoo.com.cn} ; Alfred Krö ; ner^b ; Brian F. Windley^c ; Yuruo Shi^a ; Wei Zhang^a ; Liqao Zhang^d ; Weiran Yang^e

关键词：Zircon ; Mafic&ndash ; ultramafic massifs ; Asthenospheric upwelling ; Lithosphere extension ; Central Asian Orogenic Belt ; Orogenic quiescence

刊名：Lithos

出版年：2012

10.Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

作者：Angeline C.-H. Lee^&dagger ; ; Pondy Murugappan Ramanujulu^&dagger ; ; Anders Poulsen ; Meredith Williams ; Sté ; phanie Blanchard ; Diana M. Ma ; Zahid Bonday ; Kay Lin Goh ; Kee Chuan Goh ; Miah Kiat Goh ; Jeanette Wood ; Brian W. Dymock ; ^{phadbw@nus.edu.sg}

关键词：3-Phosphoinositide dependent protein kinase-1 (PDK1) ; Fragment screening ; Kinase inhibitor design ; Ligand efficiency

刊名：Bioorganic and Medicinal Chemistry Letters

出版年：2012

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