搜索页_+hERG+or+IKr

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

SpringerLink电子期刊(3)

Elsevier电子期刊(62)

在“Elsevier电子期刊”中，命中：62条，耗时：小于0.01 秒

在所有数据库中总计命中：65条

1.Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

作者：Kiyoshi Takasuna^a ; ^b ; ^c ; ^{takasuna.kiyoshi.a3@daiichisankyo.co.jp} ; Keiichi Asakura^b ; ^c ; ^d ; Seiichi Araki^b ; ^c ; ^e ; Hiroyuki Ando^b ; ^c ; ^f ; Katsuyuki Kazusa^b ; ^c ; ^g ; Takashi Kitaguchi^b ; ^c ; ^h ; Takeshi Kunimatsu^b ; ^c ; ⁱ ; Shinobu Suzuki^b ; ^c ; ^j ; Norimasa Miyamoto^b ; ^c ; ^k

关键词：CSAHi ; Consortium for Safety Assessment using Human iPS Cells ; FPDc10 ; concentration inducing FPDc prolongation by 10% ; CMIS ; cell motion imaging system ; hiPS-CMs ; human induced pluripotent stem cell-derived cardiomyocytes ; CRD ; contraction-relaxation duration ; IBD10 ; impedance-based duration from 10% rising to 10% falling amplitude ; PWD90 ; peak width duration at 90% amplitude ; MEA ; multi-electrode array ; CPMP ; committee for proprietary medicinal products ; APD ; action potential duration ; TdP ; To

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

2.hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

作者：Akil Puckerin ; PhD^* ; Kelly A. Aromolaran ; PhD^&dagger ; ; Donald D. Chang ; PhD^* ; R. Suzanne Zukin ; PhD^&dagger ; ; Henry M. Colecraft ; PhD^* ; Mohamed Boutjdir ; PhD^&Dagger ; ; ^§ ; ; ^║ ; Ademuyiwa S. Aromolaran ; PhD^* ; ^{aa3000@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：hERG 1a ; hERG 1b ; KCNH2 ; IKr ; LQT2 ; HEK293 ; Cardiomyocytes ; Guinea pig ; Potassium channel ; Truncation mutants

刊名：Heart Rhythm

出版年：2016

3.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

作者：Yihong Zhang^a ; Charlotte K. Colenso^b ; ¹ ; Aziza El Harchi^a ; Hongwei Cheng^a ; Harry J. Witchel^c ; Chris E. Dempsey^b ; ^{C.Dempsey@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jules C. Hancox^a ; ^{Jules.hancox@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; diLQTS ; drug induced long QT syndrome ; DEA ; desethylamiodarone ; HEK ; human embryonic kidney ; hERG ; human-Ether-à ; -go-go-Related Gene ; IC50 ; half-maximal inhibitory concentration ; IhERG ; ionic current carried by hERG potassium channels ; IKr ; rapid delayed rectifier potassium current ; IKs ; slow delayed rectifier potassium current ; LQTS ; long QT syndrome

刊名：Biochemical Pharmacology

出版年：2016

4.Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

作者：P. Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; C. Regan ; K. Fitzgerald ; P. Gerenser ; J. Travis ; S. Wang ; P. Fanelli ; F. Sannajust

关键词：ANES GP ; anesthetized guinea pig ; AUC ; area under the curve ; CAVB ; complete atrioventricular blockade ; Cmax ; maximal plasmatic concentration ; ECG ; electrocardiogram ; EMw ; electromechanical window ; EMw-10 ; ; &minus ; ; 10% shortening of the EMw ; GP ; guinea pig ; FDA ; Food and Drug Administration ; hERG ; human Ether-a-go-go Related Gene ; HR ; heart rate ; ICH ; International Conference on Harmonization ; IKr ; rapidly-activating delayed rectifier potassium current ; LVP ; left ventricular pressure ; N

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

关键词：APD ; action potential duration ; AERS ; adverse event reporting system ; CiPA ; Comprehensive in Vitro Proarrhythmia Assay ; EAD ; early after depolarizations ; ECG ; electrocardiogram ; HESI ; Health and Environmental Sciences Institute ; HT ; high throughput ; hSC-CM ; human cardiac stem cell derived cardiomyocyte ; hERG or IKr ; human ether-à ; -go-go related gene ; ISWG ; In Silico Working Group ; ICWG ; Ion Channel Working Group ; ICH ; International Conference on Harmonisation ; JiCSA ; Japan iPS Cardiac Safe

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

6.In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

作者：Lucia Romero^a ; ^{lurope@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Beatriz Trenor^a ; ^{btrenor@eln.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Pei-Chi Yang^b ; ^{pcyang@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; Javier Saiz^a ; ^{jsaiz@gbio.i3bh.es" class="auth_mail" title="E-mail the corresponding author} ; Colleen E. Clancy^b ; ^{ceclancy@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：aLQTS ; drug-induced or acquired long-QT syndrome ; AP ; action potential ; APD ; action potential duration ; APD90 ; action potential duration at 90% repolarization ; C1 ; closed state 1 ; C2 ; closed state 2 ; C3 ; closed state 3 ; EAD ; early-afterdepolarization ; ECG ; electrocardiogram ; I ; inactivated state ; IKr ; rapid component of the delayed rectifier current ; LQTS ; long-QT syndrome ; O ; open state ; RFI ; recovery from inactivation ; TdP ; torsade de pointes ; WT ; wild-type ; Actilide_Oc ; drug binding simultane

刊名：Journal of Molecular and Cellular Cardiology

出版年：2015

7.QT interval correction assessment in the anesthetized guinea pig

作者：Pierre Morissette ; ^{pierre_morissette@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Hillary K. Regan ; Kevin Fitzgerald ; Sylvain Bernasconi¹ ; Pamela Gerenser ; Jeffrey Travis ; Patrick Fanelli ; Frederick Sannajust ; Christopher P. Regan

关键词：ANES GP ; anesthetized guinea pig ; BP ; blood pressure ; BT ; body temperature ; GP ; guinea pig ; hERG ; human ether-a-go-go related gene ; IKr ; rapidly-activating delayed rectifier potassium current ; IKs ; slowly-activating delayed rectifier potassium current ; MAP ; mean arterial pressure ; NCE ; new chemical entity ; NBE ; new biological entity ; QTc ; heart rate corrected QT interval ; QTcb ; Bazett's heart rate QT corrected interval ; QTcf ; Fridericia's heart rate QT corrected interval ; QTcVdW ; Van de Water's

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2015

8.The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT

作者：Asma Mechakra ; Yohann Vincent ; Philippe Chevalier ; Gilles Millat ; Eckhard Ficker ; Marek Jastrzebski ; Hugo Poulin ; Val茅rie Pouliot ; Mohamed Chahine ; Georges Christ茅

关键词：APD ; Action potential duration ; APD90 ; APD at 90% repolarization ; DNA ; Deoxyribonucleic acid ; cDNA ; Cyclic DNA ; ECG ; Electrocardiogram ; ESP ; Exome Sequencing Project ; HEK293 ; Human-derived renal epithelial cell line number 293 ; hERG ; Human ether-à ; -go-go related gene ; IKr ; The rapid delayed rectifier current ; underlied in cardiac cells by hERG ; LQTS ; Long QT syndrome ; PAS domain ; Per-Arnt-Sim domain in the N-terminal branch of the hERG protein ; QT ; The QT interval of the ECG ; QTc ; The corr

刊名：Gene

出版年：25 February, 2014

9.In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

作者：Lucia Romero^a ; ^{lurope@eln.upv.es" class="auth_mail} ; Beatriz Trenor^a ; ^{btrenor@eln.upv.es" class="auth_mail} ; Pei-Chi Yang^b ; ^{pcyang@ucdavis.edu" class="auth_mail} ; Javier Saiz^a ; ^{jsaiz@gbio.i3bh.es" class="auth_mail} ; Colleen E. Clancy^b ; ^{ceclancy@ucdavis.edu" class="auth_mail}

刊名：Journal of Molecular and Cellular Cardiology

出版年：July 2014

10.Arsenic trioxide-induced hERG K⁺ channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression

作者：Ying Zhang^a ; ^b ; ¹ ; Zengxiang Dong^a ; ^b ; ¹ ; Liyan Jin^a ; Kaiping Zhang^a ; Xin Zhao^a ; Jia Fu^a ; Yan Gong^a ; Mingming Sun^a ; Baofeng Yang^a ; ^b ; Baoxin Li^a ; ^b ; ^{libx64@hotmail.com}

关键词：As2O3 ; Matrine ; Oxymatrine ; hERG ; Sp1

刊名：Biochemical Pharmacology

出版年：2013

按检索点细分(62)

题名(1)

关键词(41)

文摘(16)

按出版年细分(62)

2027年及以后(3)

2017年(1)

2016年(4)

2015年(2)

2013年(4)

2012年(3)

2011年(3)

2010年(5)

2009年(6)

2007年(27)

2006年(1)

2005年(1)

2004年(1)

2000年及以前(1)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700