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在“Elsevier电子期刊”中，命中：8条，耗时：0.0619612 秒

在所有数据库中总计命中：9条

1.Donepezil聽+聽propargylamine聽+聽8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

作者：Li Wang^a ; ¹ ; Gerard Esteban^b ; ¹ ; Masaki Ojima^a ; Oscar M. Bautista-Aguilera^c ; Tsutomu Inokuchi^a ; ; Ignacio Moraleda^d ; Isabel Iriepa^d ; Abdelouahid Samadi^c ; Moussa B.H. Youdim^e ; Alejandro Romero^f ; Elena Soriano^g ; Raquel Herrero^h ; Ana Patricia Ferná ; ndez Ferná ; ndez^h ; Ricardo-Martí ; nez-Murillo^h ; José ; Marco-Contelles^c ; ; Mercedes Unzeta^b ; ^{Mercedes.Unzeta@uab.cat" class="auth_mail} ; ^{mercedes.unzeta@uab.es" class="auth_mail}

关键词：Donepezil + Propargylamine + 8-Hydroxyquinoline hybrids ; Multifunctional drugs ; Fe/Cu/Zn chelators ; ChE and MAO inhibitors ; In vivo scopolamine-induced long-term memory deficit ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：10 June 2014

2.Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

作者：Abdelouahid Samadi^a ; ^{samadi@iqog.csic.es} ; Cristó ; bal de los Rí ; os^b ; ^c ; ^{cristobal.delosrios@uam.es} ; Irene Bolea^d ; ^{irene_bolea@hotmail.com} ; Mourad Chioua^a ; ^{mchioua@iqog.csic.es} ; Isabel Iriepa^b ; ^{isabel.iriepa@uah.es} ; Ignacio Moraleda^b ; ^{ignacio.moraleda@uah.es} ; Manuela Bartolini^e ; ^{manuela.bartolini3@unibo.it} ; Vincenza Andrisano^e ; ^{vincenza.andrisano@unibo.it} ; Enrique Gá ; lvez^b ; ^{enrique.galvez@uah.es} ; Carolina Valderas^a ; ^{carolina.valderas@iqog.csic.es} ; Mercedes Unzeta^d ; ^{mercedes.unzeta@uab.cat} ; José ; Marco-Contelles^a ; ^{jlmarco@iqog.csic.es}

关键词：Indoles ; Naphthyridines ; Multipotent molecules ; EeAChE ; eqBuChE ; MAO-A ; MAO-B ; Kinetic analysis ; Inhibition mechanism ; Molecular modeling ; Amyloid ¦Â ; Alzheimer's disease

刊名：European Journal of Medicinal Chemistry

出版年：2012

3.LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

作者：Laura Ferná ; ndez-Ferná ; ndez^a ; Gemma Comes^b ; Irene Bolea^a ; Tony Valente^a ; Jessica Ruiz^c ; Patricia Murtra^a ; Bartolomé ; Ramirez^d ; Neus Anglé ; s^d ; Jordi Reguant^d ; José ; Ramó ; n Morelló ; ^d ; Mercè ; Boada^e ; Juan Hidalgo^b ; Rosa Marí ; a Escorihuela^c ; Mercedes Unzeta^a ; ^{Mercedes.unzeta@uab.cat}

关键词：Polyphenols ; Polyunsaturated fatty acids ; Memory and learning ; Aging ; Alzheimer's disease

刊名：Behavioural Brain Research

出版年：2012

4.Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer¡¯s disease

作者：Abdelouahid Samadi^a ; ^{samadi@iqog.csic.es} ; Mourad Chioua^a ; ^{mchioua@iqog.csic.es} ; Irene Bolea^b ; ^{Irene.Bolea@campus.uab.cat} ; Cristó ; bal de los Rí ; os^c ; ^d ; ^{cristobal.delosrios@uam.es} ; Isabel Iriepa^d ; ^{isabel.iriepa@uah.es} ; Ignacio Moraleda^d ; ^c ; ^{ignacio.moraleda@uah.es} ; Agatha Bastida^e ; ^{agatha.bastida@iqog.csic.es} ; Gerard Esteban^b ; ^{gerardo.esteban@uab.cat} ; Mercedes Unzeta^b ; ^{mercedes.unzeta@uab.cat} ; Enrique Gá ; lvez^d ; ^{enrique.galvez@uah.es} ; José ; Marco-Contelles^a ; ^{jlmarco@iqog.csic.es}

关键词：Pyridines ; Naphthyridines ; Multipotent molecules ; AChE ; BuChE ; MAO-A ; MAO-B ; Kinetic analysis ; Inhibition mechanism ; Molecular modeling ; Alzheimer&rsquo ; s disease

刊名：European Journal of Medicinal Chemistry

出版年：2011

5.p53 phosphorylation is involved in vascular cell death induced by the catalytic activity of membrane-bound SSAO/VAP-1

作者：Montse Solé ; Mar Hern ; ez-Guillamon ; Mercè ; Boada ; Mercedes Unzeta

关键词：Semicarbazide sensitive amine oxidase ; Transmembrane protein ; Methylamine ; Apoptosis ; p53 ; Smooth muscle cells

刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research

出版年：2008

6.Soluble Semicarbazide Sensitive Amine Oxidase (SSAO) catalysis induces apoptosis in vascular smooth muscle cells

作者：Mar Hernandez ; Montse Solé ; Mercè ; Boada and Mercedes Unzeta

关键词：Semicarbazide Sensitive Amine Oxidase ; Methylamine ; Formaldehyde ; Hydrogen peroxide ; Apoptosis ; Aortic smooth muscle cell

刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research

出版年：2006

7.Human plasma semicarbazide sensitive amine oxidase (SSAO), ????-amyloid protein and aging

作者：del Mar Hernandez ; Maria ; Esteban ; Miriam ; Szabo ; Paul ; Boada ; Merc?? ; Unzeta ; Mercedes

关键词：Semicarbazide sensitive amine oxidase ; Alzheimer disease ; β ; -Amyloid ; Global deterioration scale ; Aging ; Oxidative stress ; Hydrogen peroxide

刊名：Neuroscience Letters

出版年：2005

8.The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses

作者：O'Sullivan ; Jeffrey ; O'Sullivan ; Michael ; Tipton ; Keith F. ; Unzeta ; Mercedes ; Del Mar Hernandez ; Maria ; et. al.

关键词：Galactosamine ; Inhibition ; Vascular-adhesion protein 1 (VAP-1) ; MAO ; monoamine oxidase ; SSAO ; semicarbazide-sensitive amine oxidase ; VAP-1 ; vascular-adhesion protein 1

刊名：Biochimica et Biophysica Acta - Proteins and Proteomics

出版年：2003

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