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Elsevier电子期刊(13)

在“Elsevier电子期刊”中，命中：13条，耗时：0.0630001 秒

在所有数据库中总计命中：18条

1.Ser⁴²² phosphorylation blocks human Tau cleavage by caspase-3: Biochemical implications to Alzheimer’s Disease

作者：Priya Sandhu^a ; Mansur Mohammad Naeem^a ; Chunyu Lu^a ; Premkumari Kumarathasan^b ; James Gomes^a ; Ajoy Basak^a ; ^c ; ¹ ; ^{abasa2@uottawa.ca}

关键词：Aa ; amino acid ; ACN ; acetonitrile ; AUFS ; absorbance units full scale ; CHCA ; 1-Cyano 4-Hydroxy Cinnamic Acid ; Da ; Dalton ; DHB ; 2 ; 5-dihydroxy benzoic acid ; DMF ; N ; N&prime ; -dimethyl formamide ; EDT ; ethane dithiol ; h ; human ; HATU ; 1-[Bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; HBTU ; NN ; N&prime ; N&prime ; -Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate ; HOBT ; 1-hydroxy benzotriazole ; kDa ; kilo Dalton ; MALDI-Tof MS ; matrix assisted laser

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

作者：Maria De Rosa^a ; ^g ; Lu Lu^b ; ^g ; Edouard Zamaratski^a ; Natalia Szałaj^a ; Sha Cao^c ; Henrik Wadensten^d ; Lena Lenhammar^e ; Johan Gising^a ; Annette K. Roos^f ; Douglas L. Huseby^c ; Rolf Larsson^e ; Per E. André ; n^d ; Diarmaid Hughes^c ; Peter Brandt^a ; Sherry L. Mowbray^b ; ^f ; ^{Sherry.Mowbray@icm.uu.se} ; Anders Karlé ; n^a ; ^{Anders.Karlen@orgfarm.uu.se}

关键词：dabcyl ; 4-((4-(dimethylamino)phenyl)azo)benzoic acid ; DCM ; dichloromethane ; DIEA ; N ; N-diisopropylethylamine ; DMF ; N ; N-dimethylformamide ; E. coli ; Escherichia coli ; EDANS ; 5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid ; EDCI ; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide ; Fmoc ; 9-fluorenylmethoxycarbonyl ; HBTU ; NN ; N&prime ; N&prime ; -tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxide hexafluorophosph

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor

作者：Zhuang Jin^a ; Hua Lin^a ; Sathish Srinivasan^b ; Jerome C. Nwachukwu^b ; Nelson Bruno^b ; Patrick R. Griffin^a ; Kendall W. Nettles^b ; ; Theodore M. Kamenecka^a ; ^{kameneck@scripps.edu}

关键词：AF-1 ; activation function-1 ; AF-2 ; activation function-2 ; AP-1 ; activator protein 1 ; dppp ; 1 ; 3-bis(diphenylphosphino)propane ; DEX ; dexamethasone ; DIEA ; N ; N-diisopropylethylamine ; FKBP5 ; FK506-binding protein 5 ; GR ; glucocorticoid receptor ; GRE ; glucocorticoid-response element ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; IL-6 ; Interleukin-6 ; LBD ; ligand-binding domain ; LPS ; lipopolysaccharide ; MMTV ; mouse mammary tumor virus ; NF-κB ; nuclear

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect

作者：Takashi Kanamori^a ; Takashi Sawamura^a ; Tatsumi Tanaka^a ; Izumi Sotokawa^a ; Ryota Mori^a ; Kotaro Inada^a ; Akihiro Ohkubo^a ; Shun-Ichiro Ogura^a ; Yasutoshi Murayama^b ; Eigo Otsuji^b ; Hideya Yuasa^a ; ^{hyuasa@bio.titech.ac.jp}

关键词：DIC ; 1 ; 3-diisopropylcarbodiimide ; DIPEA ; N ; N-diisopropylethylamine ; DLS ; dynamic light scattering ; DMAP ; N ; N-dimethyl-4-aminopyridine ; DMF ; N ; N-dimethylformamide ; DMEM ; Dulbecco&rsquo ; s Modified Eagle Medium ; EPR effect ; enhanced permeability and retention effect ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; HOBt ; 1-hydroxybenzotriazole ; MTT ; 3-[4 ; 5-dimethylthiazol-2-yl]-2 ; 5-diphenyltetrazolium bromide

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.A facile semi-synthetic approach towards halogen-substituted aminobenzoic acid analogues of platensimycin

作者：Lin Qiu^a ; Kai Tian^a ; Jian Pan^a ; Lin Jiang^a ; Hu Yang^c ; Xiangcheng Zhu^a ; ^b ; ^c ; Ben Shen^e ; ^f ; ^g ; Yanwen Duan^a ; ^b ; ^c ; ^d ; ; Yong Huang^a ; ^b ; ^d ; ^{jonghuang@csu.edu.cn}

关键词：Platensimycin ; Platensic acid ; Halogen-substituted aminobenzoate ; Methicillin-resistant Staphylococcus aureus

刊名：Tetrahedron

出版年：2017

6.Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition

作者：Hideyuki Igawa^a ; ^{hideyuki.igawa@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Masashi Takahashi^a ; Mikio Shirasaki^a ; Keiko Kakegawa^a ; Asato Kina^a ; Minoru Ikoma^a ; Jumpei Aida^a ; Tsuneo Yasuma^b ; Shoki Okuda^a ; Yayoi Kawata^a ; Toshihiro Noguchi^a ; Syunsuke Yamamoto^a ; Yasushi Fujioka^a ; Mrinalkanti Kundu^c ; Uttam Khamrai^c ; Masaharu Nakayama^a ; Yasutaka Nagisa^d ; Shizuo Kasai^a ; Tsuyoshi Maekawa^a

关键词：MCH ; melanin-concentrating hormone ; MCHR1 ; melanin-concentrating hormone receptor 1 ; CYP3A4 ; cytochrome P450 3A4 ; TDI ; time-dependent inhibition ; DIO ; diet-induced obesity ; hERG ; human ether-a-go-go related gene ; DMEDA ; N ; N&prime ; -dimethylethylenediamine ; HATU ; (1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate) ; DIPEA ; N ; N-diisopropylethylamine ; TFAA ; trifluoroacetic anhydride ; ADDP ; 1 ; 1&prime ; -(azodicarbonyl)dipiperidine ; MW ; microwave ; CHO ; Chinese

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations

作者：Srinivas Deekonda^a ; Jacob Cole^a ; Sydney Sunna^a ; David Rankin^b ; Tally M. Largent-Milnes^b ; Peg Davis^b ; Neemah M. BassiriRad^b ; Josephine Lai^b ; Todd W. Vanderah^b ; Frank Porecca^b ; Victor J. Hruby^a ; ^{hruby@email.arizona.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ACN ; acetonitrile ; Boc ; tert-butyloxycarbonyl ; CHO ; Chinese hamster ovary ; DAMGO ; [D-Ala2 ; NMePhe4 ; Gly5-ol]enkephalin ; DALEA ; [D-Ala2 ; Leu5] enkephalin amide ; DCM ; dichloromethane ; DIPEA ; N ; N-diisopropylethylamine ; HBTU ; NN ; N&prime ; N&prime ; -tetra methyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate ; hDOR ; human δ opioid receptor ; Dmt ; 2 ; 6-dimethyltyrosine ; DPDPE ; c[D-Pen2 ; DPen5]enkephalin ; GPI ; guinea pig isolated ileum ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridi

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold

作者：Zhixiang Xu^a ; ^&dagger ; ; Xiangxiang Xu^a ; ^&dagger ; ; Ruadhan O&rsquo ; Laoi^b ; Haikuo Ma^a ; Jiyue Zheng^a ; ^{jyzheng@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Shuaishuai Chen^c ; Lusong Luo^c ; ^{lusong.luo@beigene.com" class="auth_mail" title="E-mail the corresponding author} ; Zhilin Hu^d ; Sudan He^d ; Jiajun Li^a ; Hongjian Zhang^a ; Xiaohu Zhang^a ; ^{xiaohuzhang@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：BPO ; benzoyl peroxide ; DCM ; dichloromethane ; DIPEA ; N ; N-diisopropylethylamine ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethyl sulfoxide ; FaSSIF ; fasted state simulated intestinal fluid ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; SEM ; standard error measurement ; SGF ; simulated gastric fluid ; STF ; super-top flash ; TFA ; trifluoroacetic acid

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

作者：Srinivas Deekonda^a ; Lauren Wugalter^a ; David Rankin^b ; Tally M. Largent-Milnes^b ; Peg Davis^b ; Yue Wang^b ; Neemah M. Bassirirad^b ; Josephine Lai^b ; Vinod Kulkarni^a ; Todd W. Vanderah^b ; Frank Porreca^b ; Victor J. Hruby^a ; ^{hruby@email.arizona.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ACN ; Acetonitrile ; Boc ; tert-butyloxycarbonyl ; CHO ; Chinese hamster ovary ; DCM ; Dichloromethane ; DIPEA ; N ; N-Diisopropylethylamine ; DALEA ; [D-Ala2 ; Leu5] enkephalin amide ; DAMGO ; [D-Ala2 ; NMePhe4 ; Gly5-ol]enkephalin ; Dmt ; 2 ; 6-dimethyltyrosine ; DPDPE ; c[D-Pen2 ; DPen5]enkephalin ; GPI ; guinea pig isolated ileum ; HBTU ; NN ; N&prime ; N&prime ; -Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate ; HATU ; 1-[Bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium3-oxid hexafluorophosphate

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

10.Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

作者：Sudhir Landge^a ; Amrita B. Mullick^a ; Kavitha Nagalapur^a ; Joã ; o Neres^c ; Venkita Subbulakshmi^a ; Kannan Murugan^a ; Anirban Ghosh^a ; Claire Sadler^b ; Mick D. Fellows^b ; Vaishali Humnabadkar^a ; Jyothi Mahadevaswamy^a ; Prakash Vachaspati^a ; Sreevalli Sharma^a ; Parvinder Kaur^a ; Meenakshi Mallya^a ; Suresh Rudrapatna^a ; Disha Awasthy^a ; Vasan K. Sambandamurthy^a ; Florence Pojer^c ; Stewart T. Cole^c ; Tanjore S. Balganesh^a ; Bheemarao G. Ugarkar^a ; V. Balasubramanian^a ; Balachandra S. Bandodkar^a ; Manoranjan Panda^a ; Vasanthi Ramachandran^a ; ^{vasanthi_epr@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：TB ; tuberculosis ; Mtb ; Mycobacterium tuberculosis ; MIC ; minimal inhibitory concentration ; CYP ; cytochrome P450 ; SAR ; structure&ndash ; activity relationships ; MMIC ; mammalian cytotoxicity ; DprE1 ; decaprenylphosphoryl-β-d-ribose 2&prime ; -oxidase ; TEA ; triethylamine ; HCl ; hydrochloric acid ; PCl3 ; phosphorous trichloride ; DAST ; diethylaminosulfurtrifluoride ; DIPEA ; diisopropylethylamine ; DCM ; dichloromethane ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluoroph

刊名：Bioorganic & Medicinal Chemistry

出版年：2015

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