搜索页_ Absorption distribution metabolism excretion (ADME)

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(4)	SpringerLink电子期刊(63)	ACS电子期刊(36)
Springer电子图书(2)	Elsevier电子期刊(160)

在“Elsevier电子期刊”中，命中：160条，耗时：0.0289562 秒

在所有数据库中总计命中：265条

1.Gut microbiome interactions with drug metabolism, efficacy, and toxicity

作者：Ian D. Wilson ; ^{ianwilsonprof@gmail.com} ; Jeremy K. Nicholson

关键词：ADMET ; absorption ; distribution ; metabolism ; excretion ; toxicity ; AHR ; aryl hydrocarbon receptor ; AUC ; area under the curve ; BVU ; (E)-5-(2-bromovinyl) uracil ; CAR ; constitutive androstane receptor ; cMOAT ; Canalicular multispecific organic anion transporter 1 ; cgr ; cardiac glycoside reductase ; CYP450s ; cytochromes P450 ; DPD ; dihydropyrimidine dehydrogenase ; DNA ; deoxyribonucleic acid ; EPHXs ; epoxide hydrolases ; DMI&rsquos ; drug-microbiome interactions ; FDA ; Food and Drug Administration ; GF ; germ

刊名：Translational Research

出版年：2017

2.Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

作者：Samer K. Khaled¹ ; ² ; ^{samerkm@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Joycelynne M. Palmer³ ; Josef Herzog⁴ ; Tracey Stiller³ ; Ni-Chun Tsai³ ; David Senitzer⁵ ; Xueli Liu³ ; Sandra H. Thomas¹ ; Sepideh Shayani⁶ ; Jeffrey Weitzel⁴ ; Stephen J. Forman¹ ; Ryotaro Nakamura¹

关键词：Immunosuppressant ; Drug absorption ; distribution ; metabolism ; and excretion (ADME) ; Pharmacogenetics

刊名：Biology of Blood and Marrow Transplantation

出版年：2016

3.Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey

作者：Shawn A. Gannon^a ; ^{shawn.a.gannon@chemours.com" class="auth_mail" title="E-mail the corresponding author} ; William J. Fasano^b ; Michael P. Mawn^c ; Diane L. Nabb^b ; Robert C. Buck^a ; L. William Buxton^a ; Gary W. Jepson^a ; Steven R. Frame^b

关键词：Fluoropolymer ; ADME ; Rodent ; Monkey ; Pharmacokinetics ; Toxicokinetics

刊名：Toxicology

出版年：2016

4.Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid

作者：Teng Ai ; Li Qiu ; Jiashu Xie ; Robert J. Geraghty ; Liqiang Chen ; ^{chenx462@umn.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ABPP ; activity-based protein profiling ; ADME ; absorption ; distribution ; metabolism ; and excretion ; DAAs ; direct-acting antivirals ; DPBS ; Dulbecco&rsquo ; s phosphate-buffered saline ; HCV ; hepatitis C virus ; HDACs ; histone deacetylases ; HTAs ; host-targeting antivirals ; 2mA ; 2&prime ; -C-methyl adenosine ; MMPs ; matrix metalloproteinases ; NADPH ; nicotinamide adenine dinucleotide phosphate ; RT-qPCR ; reverse transcription and quantitative PCR ; SAR ; structure&ndash ; activity relationship ; SOC ; standard of

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats

作者：Ola Sternebring ; Jesper Kammersgaard Christensen ; Inga Bjø ; rnsdottir ; ^{Inbj@novonordisk.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ADME ; absorption ; distribution ; metabolism ; and excretion ; AMS ; accelerator mass spectrometry ; AUC ; area under the plasma concentration&ndash ; time curve from zero to infinity ; AUC[0&ndash ; t] ; area under the plasma concentration&ndash ; time curves from zero to time t ; AUCextrap ; extrapolated area under the plasma concentration&ndash ; time curves from the last sampling time point to infinity ; CL ; total plasma clearance ; CLd ; intercompartmental distribution clearance ; C0 ; concentration at time zero

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

6.Pharmacokinetics for the prescriber

作者：Yijing He ; Howard L. McLeod

关键词：Drug absorption ; drug metabolism ; elimination ; excretion ; half-life ; pharmacokinetics

刊名：Medicine

出版年：2016

7.PBPK modeling and simulation in drug research and development

作者：Xiaomei Zhuang^a ; Chuang Lu^b ; ^{chuang.lu@biogen.com" class="auth_mail" title="E-mail the corresponding author}

关键词：PBPK ; PK prediction ; Absorption ; Metabolism ; Drug&ndash ; drug interaction ; Special population

刊名：Acta Pharmaceutica Sinica B

出版年：2016

8.Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes

作者：Benjamin A. Kandel^a ; ^b ; Maria Thomas^a ; ^b ; Stefan Winter^a ; ^b ; Georg Damm^c ; Daniel Seehofer^c ; Oliver Burk^a ; ^b ; Matthias Schwab^a ; ^b ; ^d ; Ulrich M. Zanger^a ; ^b ; ^{uli.zanger@ikp-stuttgart.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ADME ; absorption ; distribution ; metabolism ; excretion ; CAR ; constitutive androstane receptor (NR1I3) ; CITCO ; 6-(4-Chlorophenyl)imidazo[2 ; 1-b][1 ; 3]thiazole-5-carbaldehyde O-(3 ; 4-dichlorobenzyl)oxime ; CYP ; cytochrome P450 ; DMET ; drug metabolism and transport ; PHH ; primary human hepatocytes ; PPARα ; peroxisome proliferator-activated receptor alpha (NR1C1) ; PXR ; pregnane X receptor (NR1I2) ; WY14 ; 643 ; [[4-chloro-6-[(2 ; 3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid

刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

出版年：2016

9.“Hepatocellular carcinoma: A life-threatening disease”

作者：Shinu Chacko ; ^{shinu10015@bitmesra.ac.in} ; Subir Samanta

关键词：ADME ; absorption distribution metabolism and excretion ; AFP ; alpha-fetoprotein ; BCLC ; Barcelona Clinic Liver Cancer ; Chk 1 ; check point 1 ; HBV ; Hepatitis B Virus ; HCC ; hepatocellular carcinoma ; HCV ; Hepatitis C Virus ; LT ; liver transplatation ; NAFLD ; nonalcoholic fatty liver disease ; PDGF ; platelet-derived growth factor ; PS ; performance status ; TACE ; transarterial chemoembolization ; TSC ; thiosemicarbazide ; VEGFR ; vascular endothelial growth factor receptors

刊名：Biomedicine & Pharmacotherapy

出版年：2016

10.In silico pharmacology: Drug membrane partitioning and crossing

作者：Florent Di Meo^a ; Gabin Fabre^b ; Karel Berka^c ; Tahani Ossman^a ; Benjamin Chantemargue^a ; ^c ; Marké ; ta Paloncý ; ová ; ^c ; Pierre Marquet^a ; Michal Otyepka^c ; Patrick Trouillas^a ; ^c ; ^{patrick.trouillas@unilim.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：ABC ; ATP-binding cassette ; ADME ; absorption ; distribution ; metabolism and excretion ; AMP ; antimicrobial peptide ; CG ; coarse-grained ; COX ; cyclooxygenase ; CYP ; cytochrome P450 ; DLiPC ; dilinoeyl-phosphatidylcholine ; DOPC ; 1 ; 2-dioleoyl-sn-glycero-3-phosphocholine ; GA ; general anesthetic ; GlpT ; glycerol-3-phosphate ; phosphate transporter ; GLUT1 ; glucose transporter ; GST ; glutathione S-transferase ; IF ; inward facing ; LA ; local anesthetic ; LacY ; lactose permease ; MATE ; multi-antimicrobial extrusion pro

刊名：Pharmacological Research

出版年：2016

按检索点细分(160)

题名(4)

关键词(76)

文摘(83)

按出版年细分(160)

2027年及以后(7)

2017年(1)

2016年(23)

2015年(12)

2013年(19)

2012年(17)

2011年(5)

2010年(5)

2009年(9)

2008年(4)

2007年(6)

2006年(8)

2005年(3)

2004年(13)

2003年(5)

2002年(5)

2001年(4)

2000年(6)

2000年及以前(8)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700