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在“Elsevier电子期刊”中，命中：1,633条，耗时：0.0299851 秒

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1.Immobilized fusion protein affinity chromatography combined with HPLC-ESI-Q-TOF-MS/MS for rapid screening of PPARγ ligands from natural products

作者：Junfeng Zhu ; Xiaojiao Yi ; Wenhui Liu ; Yingchun Xu ; Shuqing Chen ; Yongjiang Wu ; ^{yjwu@zju.edu.cn}

关键词：Peroxisome proliferator-activated receptor-γ ; Immobilized fusion protein affinity chromatography ; HPLC&ndash ; ESI-Q-TOF-MS/MS ; Multicomponent screening ; Natural products

刊名：Talanta

出版年：2017

2.Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor

作者：Hiroki Mano^a ; Miyu Nishikawa^a ; ^b ; Kaori Yasuda^a ; Shinichi Ikushiro^a ; Nozomi Saito^c ; ¹ ; Daisuke Sawada^c ; ² ; Shinobu Honzawa^c ; ³ ; Masashi Takano^c ; Atsushi Kittaka^c ; Toshiyuki Sakaki^a ; ^b ; ^{tsakaki@pu-toyama.ac.jp}

关键词：VDR ; vitamin D receptor ; RXRα ; retinoid X receptor α ; LBD ; ligand binding domain ; VDRE ; vitamin D responsive element ; LucN ; N-terminal domain of luciferase ; LucC ; C-terminal domain of luciferase

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

3.NMR characterization of weak interactions between RhoGDI2 and fragment screening hits

作者：Jiuyang Liu ; Jia Gao ; Fudong Li ; Rongsheng Ma ; Qingtao Wei ; Aidong Wang ; Jihui Wu ; Ke Ruan ; ^{kruan@ustc.edu.cn}

关键词：Fragment-based lead discovery ; Rho guanine-nucleotide dissociation inhibitor 2 ; Transferred paramagnetic relaxation enhancement ; Non-uniform sampling NMR ; Posttranslational modification

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2017

4.Structure-activity relationship-based screening of antibiotics against Gram-negative Acinetobacter baumannii

作者：Jee-Young Lee^a ; ^c ; Min-Cheol Jeong^b ; ^c ; Dasom Jeon^b ; Yeongjun Lee^b ; Woo Cheol Lee^b ; Yangmee Kim^b ; ^{ymkim@konkuk.ac.kr}

关键词：KAS ; Fatty acid synthesis ; Antibiotics ; In silico screening ; Gram-negative bacteria

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Virtual screening and biophysical studies lead to HSP90 inhibitors

作者：Renjie Huang ; Daniel M. Ayine-Tora ; M. Nasri Muhammad Rosdi ; Yu Li ; Jó ; hannes Reynisson ; ^{j.reynisson@auckland.ac.nz} ; Ivanhoe K.H. Leung ; ^{i.leung@auckland.ac.nz}

关键词：17-AAG ; 17-allylamino-17-demethoxygeldanamycin ; 17-DMAG ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) ; ADP ; adenosine diphosphate ; AMPPCP ; 5&prime ; -adenylylmethylenediphosphonate ; ASP ; Astex statistical potential ; ATP ; adenosine triphosphate ; CS ; ChemScore ; GS ; GoldScore ; HB ; hydrogen bonding ; HSP90 ; heat shock protein 90 ; HSQC ; heteronuclear single quantum correlation ; KD ; binding affinity ; ND ; N-domain ; NMR ; nuclear magnetic resonance ; NOE ; nuclear Overhauser effect ; Tm ; pro

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

6.Acyl chain preference and inhibitor identification of Moraxella catarrhalis LpxA: Insight through crystal structure and computational studies

作者：Shivendra Pratap ; Pooja Kesari ; Ravi Yadav ; Aditya Dev ; Manju Narwal ; Pravindra Kumar ; ^{pravshai@gmail.com}

关键词：UDP-N-acetylglucosamine acyltransferase ; Crystal structure ; Hydrocarbon ruler ; Virtual screening ; Acyl carrier protein

刊名：International Journal of Biological Macromolecules

出版年：2017

7.Array-based functional peptide screening and characterization of gold nanoparticle synthesis

作者：Masayoshi Tanaka^a ; ^b ; Shun Hikiba^a ; Kiyoto Yamashita^a ; Masaki Muto^a ; ^b ; Mina Okochi^a ; ^b ; ^{okochi.m.aa@m.titech.ac.jp}

关键词：AuNP ; gold nanoparticle ; SH ; sulfhydryl ; AuP ; AuNP binding peptides screened with a peptide array ; GRAVY ; grand average of hydropathy ; SEM ; scanning electron microscope ; SPR ; surface plasmon resonance ; TEM ; transmission electron microscopy

刊名：Acta Biomaterialia

出版年：2017

8.The characterization and validation of 17β-estradiol binding aptamers

作者：Marké ; ta Svobodová ; ^a ; Vasso Skouridou^a ; ^{vasoula.skouridou@urv.cat} ; Mary Luz Botero^a ; Miriam Jauset-Rubio^a ; Thomas Schubert^b ; Abdulaziz S. Bashammakh^c ; Mohammad S. El-Shahawi^c ; Abdulrahman O. Alyoubi^c ; Ciara K. O&rsquo ; Sullivan^a ; ^d ; ^{ciara.osullivan@urv.cat}

关键词：17β-estradiol ; Aptamers ; Small molecule ; Microscale thermophoresis (MST) ; Apta-PCR affinity assay (APAA) ; Surface Plasmon Resonance (SPR)

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

9.Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach

作者：Surza L.G. Rocha^a ; ^d ; Ana G.C. Neves-Ferreira^a ; ^d ; ^{anag@ioc.fiocruz.br} ; ^{anagextra@gmail.com} ; Monique R.O. Trugilho^a ; ^d ; ¹ ; Yamileth Angulo^b ; Bruno Lomonte^b ; Richard H. Valente^a ; ^d ; Gilberto B. Domont^c ; ^d ; Jonas Perales^a ; ^d ; ^{jperales@ioc.fiocruz.br} ; ^{jonasperales@gmail.com}

关键词：Snake venoms ; Myotoxin ; Myotoxin inhibitor ; Didelphis aurita ; Proteomics ; Interactomics

刊名：Journal of Proteomics

出版年：2017

10.Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation

作者：T. Pragna Lakshmi^a ; ^{pragnapcu@gmail.com} ; Amit Kumar^a ; ^{amit.kumar10nov@gmail.com} ; Veena Vijaykumar^b ; ^{btveenavijaykumar@gmail.com} ; Sakthivel Natarajan^b ; ^{puns2005@gmail.com} ; Ramadas Krishna^a ; ^{krishstrucbio@gmail.com}

关键词：PKB ; protein kinase B ; CPH ; common pharmacophore hypothesis ; RMSE ; root mean-square error ; PLS ; partial least-squares ; QSAR ; quantitative structure-activity relationship ; TCM ; traditional Chinese medicine ; HTVS ; high-throughput virtual screening ; SP ; standard precision ; XP ; extra precision ; DFT ; density functional theory ; HOMO ; higher occupied frontier orbitals ; LUMO ; lower unoccupied frontier orbitals ; MDS ; molecular dynamic simulations

刊名：International Journal of Biological Macromolecules

出版年：2017

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