作者：J. Phillip Turner^a ; Shelby E. Chastain^b ; Dongwon Park^a ; Melissa A. Moss^b ; ^c ; Shannon L. Servoss^a ; ^{sservoss@uark.edu}

关键词：AD ; Alzheimer&rsquo ; s disease ; Aβ ; amyloid-β protein ; Aβ40 ; amyloid-β 1&ndash ; 40 ; Aβ42 ; amyloid-β 1&ndash ; 42 ; HD ; Huntington&rsquo ; s disease ; ThT ; thioflavin T ; DMF ; dimethylformamide ; TFA ; trifluoroacetic acid ; HPLC ; high performance liquid chromatography ; TEM ; transmission electron microscopy ; DMSO ; dimethyl sulfoxide

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

作者：Xiaoyao Zheng ; Xiaoying Pang ; Peng Yang ; Xu Wan ; Yue Wei ; Qian Guo ; Qizhi Zhang ; ^{qzzhang@fudan.edu.cn} ; Xinguo Jiang

关键词：Cationic hybrid complex ; siRNA delivery ; Blood-brain barrier (BBB) ; Amyloid plaque ; Alzheimer&rsquo ; s disease

刊名：Acta Biomaterialia

出版年：2017

作者：Priya Sandhu^a ; Mansur Mohammad Naeem^a ; Chunyu Lu^a ; Premkumari Kumarathasan^b ; James Gomes^a ; Ajoy Basak^a ; ^c ; ¹ ; ^{abasa2@uottawa.ca}

关键词：Aa ; amino acid ; ACN ; acetonitrile ; AUFS ; absorbance units full scale ; CHCA ; 1-Cyano 4-Hydroxy Cinnamic Acid ; Da ; Dalton ; DHB ; 2 ; 5-dihydroxy benzoic acid ; DMF ; N ; N&prime ; -dimethyl formamide ; EDT ; ethane dithiol ; h ; human ; HATU ; 1-[Bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; HBTU ; NN ; N&prime ; N&prime ; -Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate ; HOBT ; 1-hydroxy benzotriazole ; kDa ; kilo Dalton ; MALDI-Tof MS ; matrix assisted laser

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

作者：Jutamas Jiaranaikulwanitch^a ; ^b ; ^{jutamas.jia@cmu.ac.th} ; Sarin Tadtong^c ; Piyarat Govitrapong^d ; Valery V. Fokin^e ; Opa Vajragupta^b

关键词：Bis-tryptoline triazole ; Multifunctional activity ; Neuritogenic activity ; β-secretase inhibitor ; β-amyloid aggregation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

作者：B. Laumbacher ; B. Fellerhoff-Loesch ; R. Wank ; ^{professor-wank@muenchen-mail.de}

刊名：Medical Hypotheses

出版年：2017

作者：Rosalie M. Sterner ; BS ; BA^a ; Paul Y. Takahashi ; MD^b ; Aimee C. Yu Ballard ; MD ; PhD^b ; ^{yu.aimee@mayo.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer vaccine ; Alzheimer immunotherapy ; Alzheimer treatment

刊名：Journal of the American Medical Directors Association

出版年：2016

作者：Simona Mancini ; MS^a ; ^{s.mancini6@campus.unimib.it" class="auth_mail" title="E-mail the corresponding author} ; Stefania Minniti ; MS^a ; ^{stefania.minniti1@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Maria Gregori ; PhD^a ; ^{maria.gregori@unimib.it" class="auth_mail" title="E-mail the corresponding author} ; Giulio Sancini ; MS^a ; ^{giulio.sancini@unimib.it" class="auth_mail" title="E-mail the corresponding author} ; Alfredo Cagnotto ; MS^b ; ^{alfredo.cagnotto@marionegri.it" class="auth_mail" title="E-mail the corresponding author} ; Pierre-Olivier Couraud ; PhD^c ; ^{pierre-olivier.couraud@inserm.fr" class="auth_mail" title="E-mail the corresponding author} ; Lara Ordó ; ñ ; ez-Gutié ; rrez ; MS^d ; ^{lordoniez@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author} ; Francisco Wandosell ; PhD^d ; ^{fwandosell@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author} ; Mario Salmona ; PhD^b ; ^{mario.salmona@marionegri.it" class="auth_mail" title="E-mail the corresponding author} ; Francesca Re ; PhD^a ; ^{francesca.re1@unimib.it" class="auth_mail" title="E-mail the corresponding author}

关键词：β-Amyloid oligomers ; Alzheimer disease ; Sink effect ; Nanoparticles ; Liposomes

刊名：Nanomedicine: Nanotechnology, Biology and Medicine

出版年：2016

作者：Riqiang Yan ; ^{yanr@ccf.org" class="auth_mail" title="E-mail the corresponding author} ; Qingyuan Fan ; John Zhou ; Robert Vassar¹ ; ^{r-vassar@northwestern.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：BACE1 ; Alzheimer&rsquo ; s β-secretase ; APP ; Abeta peptides ; Synapses ; NMDA receptors ; AMPA receptors ; Dopamine receptors

刊名：Neuroscience & Biobehavioral Reviews

出版年：2016

作者：Takuya Arai^a ; ^b ; Akiko Ohno^c ; Mori Kazunori^b ; Taeko Kakizawa^c ; Hiroshi Kuwata^b ; Toshihiko Ozawa^d ; Motoko Shibanuma^b ; Shuntaro Hara^b ; Seiichi Ishida^e ; Masaaki Kurihara^c ; Naoki Miyata^a ; Hidehiko Nakagawa^a ; Kiyoshi Fukuhara^b ; ^{fukuhara@pharm.showa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; amino acid ; Aβ ; amyloid-β ; AD ; Alzheimer&rsquo ; s disease ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DIPEA ; N ; N-diisopropylethylamine ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethyl sulfoxide ; HBTU ; O-(benzotriazol-1-yl)-NN ; N&prime ; N&prime ; -tetramethyluronium hexafluorophosphate ; HFIP ; 11133 ; 3-hexafluoro-2-propanol ; HOBt ; 1-hydroxybenzotriazole ; HRMS ; high resolution mass spectrometry ; PI ; propidium iodide ; ROS ; reactive oxygen species ; RP-HPLC ; reverse phase high per

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

作者：Takuya Arai^a ; ^b ; Akiko Ohno^c ; Kazunori Mori^b ; Hiroshi Kuwata^b ; Mirei Mizuno^b ; Kohei Imai^b ; Shuntaro Hara^b ; Motoko Shibanuma^b ; Masaaki Kurihara^c ; Naoki Miyata^a ; Hidehiko Nakagawa^a ; Kiyoshi Fukuhara^b ; ^{fukuhara@pharm.showa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Aβ ; amyloid-β ; AD ; Alzheimer&rsquo ; s disease ; CA ; caffeic acid ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; DHCA ; dihydrocaffeic acid ; DIPEA ; N ; N-diisopropylethylamine ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethyl sulfoxide ; Gly ; glycine ; HBTU ; O-(benzotriazol-1-yl)- NN ; N&prime ; N&prime ; -tetramethyluronium hexafluorophosphate ; HFIP ; 11133 ; 3-hexafluoro-2-propanol ; HOBt ; 1-hydroxybenzotriazole ; HRMS ; high resolution mass spectrometry ; PI ; propidium iodide ; ROS ; reactive oxy

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016