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在“Elsevier电子期刊”中，命中：869条，耗时：0.0389801 秒

在所有数据库中总计命中：1,332条

1.Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization

作者：Jun Yan ; Jinhui Hu ; Baijiao An ; Li Huang ; Xingshu Li ; ^{lixsh@mail.sysu.edu.cn}

关键词：Cyclic-indole derivatives ; Antiproliferative activity ; Tubulin polymerization inhibitor ; Cell cycle arrest ; Apoptosis

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Antibody-drug conjugate directed against the guanylyl cyclase antigen for the treatment of gastrointestinal malignancies

作者：Khaldoun Almhanna^a ; ^{Khaldoun.almhanna@moffitt.org} ; Gopi K. Prithviraj^a ; Petter Veiby^b ; Thea Kalebic^c

关键词：Antibody&ndash ; drug conjugate ; Guanylyl cyclase C ; GI malignancies

刊名：Pharmacology & Therapeutics

出版年：2017

3.Curdione attenuates thrombin-induced human platelet activation: β1-tubulin as a potential therapeutic target

作者：Dongling Zhang^a ; Wenhao Qiao^a ; Yingli Zhao^b ; Hui Fang^b ; Dujuan Xu^b ; Quan Xia^a ; ^b ; ^{xiaquan2010@163.com}

关键词：Curdione ; Platelet activation ; β1-tubulin ; Vinculin ; Talin1

刊名：Fitoterapia

出版年：2017

4.Design, synthesis and docking studies of novel 1,2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide derivatives as a potential anti-proliferative agents

作者：Saleha Banu^a ; Rajitha Bollu^a ; Rajashaker Bantu^a ; Lingaiah Nagarapu^a ; ; Sowjanya Polepalli^b ; Nishant Jain^b ; Radhika Vangala^c ; Vijjulatha Manga^c

关键词：Roquinimex ; 1 ; 2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamides ; Piperazines ; Anti-proliferative ; Multiple sclerosis ; Cell lines and molecular modeling

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

作者：Guangyao Lv^a ; ^&dagger ; ; Dengjun Sun^b ; ^&dagger ; ; Jingwen Zhang^a ; Xiaoxia Xie^a ; Xiaoqiong Wu^d ; Weishuo Fang^c ; Jingwei Tian^a ; Chunhong Yan^e ; Hongbo Wang^a ; ^{hongbowangyt@gmail.com} ; Fenghua Fu^a ; ^{fufenghua@sohu.com}

关键词：Lx2-32c ; Cephalomannine ; Prostate cancer ; Microtubule ; Cell cycle arrest ; Apoptosis

刊名：Acta Pharmaceutica Sinica B

出版年：2017

6.A novel piperazine linked β-amino alcohols bearing a benzosuberone scaffolds as anti-proliferative agents

作者：Sowmya Vanguru^a ; Lavanya Jilla^a ; Yasodakrishna Sajja^a ; Rajashaker Bantu^a ; Lingaiah Nagarapu^a ; ^{lnagarapuiict@yahoo.com} ; ^{nagarapu@iict.res.in} ; Jagadeesh Babu Nanubolu^b ; Bala Bhaskar^c ; Nishant Jain^c ; Sreekanth Sivan^d ; Vijjulatha Manga^d

关键词：Benzosuberone ; Piperazine ; β-Amino alcohol ; Anti-proliferative ; Cell lines ; Molecular modeling

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

作者：Roheeth Kumar Pavana^a ; Shruti Choudhary^a ; Anja Bastian^b ; Michael A. Ihnat^c ; Ruoli Bai^d ; Ernest Hamel^d ; Aleem Gangjee^a ; ^{gangjee@duq.edu}

关键词：AA ; antiangiogenic agents ; MTA ; microtubule targeting agents ; VEGFR-2 ; vascular endothelial growth factor receptor-2 ; PDGFR-β ; platelet-derived growth factor receptor-β ; CAM ; chorioallantoic membrane ; CA ; combretastatin A-4 ; Pgp ; P-glycoprotein ; EGFR ; epidermal growth factor receptor ; TBS ; Tris-buffered saline ; HRP ; horseradish peroxidase ; PY ; phosphotyrosine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro

作者：Mudiana Muhamad¹ ; ² ; ^{mudiana_muhamad@salam.uitm.edu.my} ; Yean Kee Lee² ; ³ ; Noorsaadah Abd. Rahman² ; ³ ; Rohana Yusof² ; ⁴

关键词：Synthesized derived ligand ; Dengue replication ; Inhibition assay ; Quantitative RT-PCR ; Cytoskeletal actin tubulin distribution

刊名：Asian Pacific Journal of Tropical Biomedicine

出版年：2017

9.3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

作者：Hsueh-Yun Lee^a ; Jiann-Fong Lee^a ; Sunil Kumar^a ; Yi-Wen Wu^b ; Wei-Chun HuangFu^c ; Mei-Jung Lai^d ; Yu-Hsuan Li^a ; Hsiang-Ling Huang^a ; Fei-Chiao Kuo^a ; Che-Jen Hsiao^e ; Chun-Chun Cheng^c ; Chia-Ron Yang^b ; ^{cryang@ntu.edu.tw} ; Jing-Ping Liou^a ; ^{jpl@tmu.edu.tw}

关键词：Anticancer agents ; Histone deacetylase inhibitors ; 3-Aroylindoles ; Tubulin polymerization inhibition

刊名：European Journal of Medicinal Chemistry

出版年：2017

10.Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds

作者：S. El-Meligie^a ; Azza T. Taher^a ; ^b ; Aliaa M. Kamal^a ; ^{Aliaa.kamal@pharma.cu.edu.eg} ; ^{K_aliaa2511@hotmail.com} ; A. Youssef^c

关键词：Chalcone derivatives ; Replacing enone bridge ; Cytotoxic activity ; Cancer cell lines ; Normal cell lines ; Tubulin beta polymerization inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

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