搜索页_ CB2 inverse agonist

设为首页

收藏本站

网站地图 | English | 公务邮箱

远程访问

NSTL服务站

外文资源

Elsevier电子期刊(34)

在“Elsevier电子期刊”中，命中：34条，耗时：0.0229908 秒

在所有数据库中总计命中：52条

1.New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

作者：Giulio Ragusa^a ; Marí ; a Gó ; mez-Cañ ; as^b ; ^c ; ^d ; Paula Morales^e ; Carmen Rodrí ; guez-Cueto^b ; ^c ; ^d ; Marí ; a R. Pazos^b ; ^c ; ^d ; Battistina Asproni^a ; Elena Cichero^f ; Paola Fossa^f ; Gerard A. Pinna^a ; Nadine Jagerovic^e ; Javier Ferná ; ndez-Ruiz^b ; ^c ; ^d ; Gabriele Murineddu^a ; ^{muri@uniss.it}

关键词：Scaffold hopping ; Synthesis ; Cannabinoid receptors ; CB2 antagonism ; ADME model ; Docking studies

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB₂ cannabinoid receptor inverse agonists

作者：Mojgan Aghazadeh Tabrizi^a ; ^{tbj@unife.it" class="auth_mail" title="E-mail the corresponding author} ; Pier Giovanni Baraldi^a ; ^{baraldi@unife.it" class="auth_mail" title="E-mail the corresponding author} ; Emanuela Ruggiero^a ; Giulia Saponaro^a ; Stefania Baraldi^a ; Giulio Poli^b ; Tiziano Tuccinardi^b ; Annalisa Ravani^c ; Fabrizio Vincenzi^c ; Pier Andrea Borea^c ; Katia Varani^c

关键词：Cannabinoid ; CB2 receptor ; Inverse agonists ; Triazolopyrimidine ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：2016

3.Synthesis and pharmacological evaluation of new biphenylic derivatives as CB₂ receptor ligands

作者：Simone Bertini^a ; ¹ ; ^{simone.bertini@unipi.it" class="auth_mail" title="E-mail the corresponding author} ; Andrea Chicca^b ; ¹ ; Chiara Arena^a ; ^b ; Stefano Chicca^b ; Giuseppe Saccomanni^a ; Jü ; rg Gertsch^b ; Clementina Manera^a ; Marco Macchia^a

关键词：CB2 ; Cannabinoid receptor ; Biphenyl-carboxamides ; CB2 agonist ; CB2 antagonist ; CB2 inverse agonist ; Methylhonokiol ; Endocannabinoid system

刊名：European Journal of Medicinal Chemistry

出版年：2016

4.Pyrazole antagonists of the CB1 receptor with reduced brain penetration

作者：Alan Fulp ; Yanan Zhang ; Katherine Bortoff ; Herbert Seltzman ; Rodney Snyder ; Robert Wiethe ; George Amato ; Rangan Maitra ; ^{rmaitra@rti.org" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; blood&ndash ; brain barrier ; BOP ; benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate ; CB ; cannabinoid receptors ; CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; CHO-K1 ; Chinese hamster ovary cells ; CMA 80 ; 80% chloroform ; 18% methanol ; and 2% ammonium hydroxide ; CNS ; central nervous system ; Ke ; apparent affinity constant ; MDCK-mdr1 ; Madin&ndash ; Darby canine kidney cells transfected with the human MDR1 gene ; IP3 ; inositol phosphatase 3 ; MRM ; multiple reaction mon

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor

作者：Valentina Lucchesi^a ; Teija Parkkari^b ; ^c ; ^{Teija.Parkkari@uef.fi" class="auth_mail} ; Juha R. Savinainen^c ; Anna Maria Malfitano^d ; Marco Allarà ; ^f ; Simone Bertini^a ; Francesca Castelli^a ; Sara Del Carlo^a ; Chiara Laezza^e ; Alessia Ligresti^f ; Giuseppe Saccomanni^a ; Maurizio Bifulco^d ; Vincenzo Di Marzo^f ; Marco Macchia^a ; Clementina Manera^a ; ^{manera@farm.unipi.it" class="auth_mail}

关键词：Cannabinoid ; CB1 receptor ; CB2 receptor ; CB2 receptor neutral antagonist ; CB2 receptor inverse agonist

刊名：European Journal of Medicinal Chemistry

出版年：3 March, 2014

6.Identification of raloxifene as a novel CB2 inverse agonist

作者：Pritesh Kumar ; Zhao-Hui Song ; ^{zhsong@louisville.edu}

关键词：CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; GPCR ; G protein-coupled receptor ; FDA ; food and drug administration ; HTRF ; homogenous time-resolved fluorescence

刊名：Biochemical and Biophysical Research Communications

出版年：2013

7.CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene

作者：Pritesh Kumar ; Zhao-Hui Song

关键词：SERM ; selective estrogen receptor modulator ; CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; GPCR ; G protein-coupled receptor ; FDA ; food and drug administration ; HTRF ; homogenous time resolved fluorescence

刊名：Biochemical and Biophysical Research Communications

出版年：3 January, 2014

8.Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity

作者：Ferenc Zá ; dor ; ^{zador.ferenc@gmail.com" class="auth_mail} ; Dó ; ra Kocsis ; Anna Borsodi ; Sá ; ndor Benyhe

关键词：[35S]GTP纬S ; guanosine-5&prime ; -O-(3-[35S]thio)triphosphate ; BBB ; blood&ndash ; brain-barrier ; CB1 ; type 1 cannabinoid receptor ; CB1/CB2 K.O. ; CB1/CB2 double knock-out ; CB2 ; type 2 cannabinoid receptor ; CHO ; Chinese hamster ovary cell line ; CHO-mDOR ; Chinese hamster ovary cell line overexpressed with mouse 未-opioid receptor ; CHO-MOR ; Chinese hamster ovary cell line overexpressed with 渭-opioid receptor ; DMSO ; dimethyl sulphoxide ; DOR ; 未-opioid receptor ; DPDPE ; [D-Pen2 ; 5]-enkephalin hydrate ; EGTA

刊名：Neurochemistry International

出版年：February, 2014

9.A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury

作者：Antonella Contartese^a ; Massimo Valoti^a ; Federico Corelli^b ; Serena Pasquini^b ; Claudia Mugnaini^b ; Federica Pessina^a ; Carlo Aldinucci^c ; Giampietro Sgaragli^a ; Maria Frosini^a ; ^{maria.frosini@unisi.it}

关键词：Oxygen glucose deprivation and reperfusion ; Brain slices ; Neuroprotection ; Cannabinoids system ; CB2 agonist ; CB2 inverse-agonist ; 4-Quinolone-3-carboxylic acid derivatives

刊名：Pharmacological Research

出版年：2012

10.Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach

作者：Bernard Le Foll^a ; ^b ; ^c ; ^d ; ^e ; ^{bernard.lefoll@camh.ca" class="auth_mail} ; Abhiram Pushparaj^a ; Yaroslaw Pryslawsky^a ; Benoit Forget^f ; Kiran Vemuri^g ; ^h ; ⁱ ; Alexandros Makriyannis^g ; ^h ; ⁱ ; Jose M. Trigo^a

关键词：伪4尾2 ; ALPHA-4 beta-2 nicotinic receptor ; 尾2 ; nicotinic receptor subunit ; AM251 ; inverse agonist at the CB1 cannabinoid receptor ; AM4113 ; CB1 putative neutral antagonist ; BOLD ; blood&ndash ; oxygen-level dependent ; cAMP ; Cyclic Adenosine Monophosphate ; CB1 ; cannabinoid receptor type 1 ; CB2 ; cannabinoid receptor type 2 ; CPP ; conditioned place preference ; DBS ; deep brain stimulation ; EU ; European Union ; FDA ; Food and Drug Administration ; fMRI ; functional magnetic resonance imaging ; GABA ; gamma-aminob

刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry

出版年：3 July 2014

按检索点细分(34)

题名(1)

关键词(10)

文摘(23)

按出版年细分(34)

2027年及以后(4)

2017年(1)

2016年(3)

2013年(4)

2012年(4)

2011年(3)

2010年(4)

2009年(2)

2008年(2)

2007年(1)

2006年(2)

2005年(2)

2004年(1)

2000年及以前(1)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700