搜索页_+CB1+inverse+agonist

常用资源

电子图书

期刊论文

学位会议

外文资源

Elsevier电子期刊(97)

在“Elsevier电子期刊”中，命中：97条，耗时：0.0319943 秒

在所有数据库中总计命中：137条

1.Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists

作者：Bin Zhu ; Jay M. Matthews ; Mingde Xia ; Shawn Black ; Cailin Chen ; Cuifen Hou ; Yin Liang ; Yuting Tang ; Mark J. Macielag

关键词：Cannabinoid receptor ; CB1 receptor ; Inverse agonist ; Peripheral selectivity ; Peripherally restricted

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists

作者：Jay M. Matthews ; James J. McNally ; Peter J. Connolly ; Mingde Xia ; Bin Zhu ; Shawn Black ; Cailin Chen ; Cuifen Hou ; Yin Liang ; Yuting Tang ; Mark J. Macielag

关键词：Cannabinoid receptor ; CB1 receptor ; Inverse agonist ; Peripheral selectivity ; Peripherally restricted

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Pyrazole antagonists of the CB1 receptor with reduced brain penetration

作者：Alan Fulp ; Yanan Zhang ; Katherine Bortoff ; Herbert Seltzman ; Rodney Snyder ; Robert Wiethe ; George Amato ; Rangan Maitra ; ^{rmaitra@rti.org" class="auth_mail" title="E-mail the corresponding author}

关键词：BBB ; blood&ndash ; brain barrier ; BOP ; benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate ; CB ; cannabinoid receptors ; CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; CHO-K1 ; Chinese hamster ovary cells ; CMA 80 ; 80% chloroform ; 18% methanol ; and 2% ammonium hydroxide ; CNS ; central nervous system ; Ke ; apparent affinity constant ; MDCK-mdr1 ; Madin&ndash ; Darby canine kidney cells transfected with the human MDR1 gene ; IP3 ; inositol phosphatase 3 ; MRM ; multiple reaction mon

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique

作者：A.-L. Sberna¹ ; ² ; ^{alsbernahayez@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; P. Degrace¹ ; B. Vergè ; s¹ ; ²

关键词：Systè ; me endocannabinoï ; de ; ré ; cepteur cannabinoï ; de de type 1 (CB1-R) ; anandamide ; rimonabant ; lipides ; tissu adipeux ; sté ; atose hé ; patique ; insulino-ré ; sistance ; syndrome mé ; tabolique ; diabè ; te de type 2

刊名：Médecine des Maladies Métaboliques

出版年：2016

5.Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats

作者：Ikram Merroun ; Cristina S谩nchez-Gonz谩lez ; Rosario Mart铆nez ; Carlos L贸pez-Chaves ; Jes煤s M. Porres ; Pilar Ara ; Juan Llopis ; Milagros Galisteo ; Antonio Zarzuelo ; Mohammed Errami ; Mar铆a L贸pez-Jurado

关键词：AM 251 ; CB1 receptor inverse agonist ; DMSO ; dimethyl sulfoxide ; AST ; aspartate transaminase ; ALT ; alanine transminase

刊名：Metabolism

出版年：November, 2013

6.1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor

作者：Valentina Lucchesi^a ; Teija Parkkari^b ; ^c ; ^{Teija.Parkkari@uef.fi" class="auth_mail} ; Juha R. Savinainen^c ; Anna Maria Malfitano^d ; Marco Allarà ; ^f ; Simone Bertini^a ; Francesca Castelli^a ; Sara Del Carlo^a ; Chiara Laezza^e ; Alessia Ligresti^f ; Giuseppe Saccomanni^a ; Maurizio Bifulco^d ; Vincenzo Di Marzo^f ; Marco Macchia^a ; Clementina Manera^a ; ^{manera@farm.unipi.it" class="auth_mail}

关键词：Cannabinoid ; CB1 receptor ; CB2 receptor ; CB2 receptor neutral antagonist ; CB2 receptor inverse agonist

刊名：European Journal of Medicinal Chemistry

出版年：3 March, 2014

7.Translational strategies for therapeutic development in nicotine addiction: Rethinking the conventional bench to bedside approach

作者：Bernard Le Foll^a ; ^b ; ^c ; ^d ; ^e ; ^{bernard.lefoll@camh.ca" class="auth_mail} ; Abhiram Pushparaj^a ; Yaroslaw Pryslawsky^a ; Benoit Forget^f ; Kiran Vemuri^g ; ^h ; ⁱ ; Alexandros Makriyannis^g ; ^h ; ⁱ ; Jose M. Trigo^a

关键词：伪4尾2 ; ALPHA-4 beta-2 nicotinic receptor ; 尾2 ; nicotinic receptor subunit ; AM251 ; inverse agonist at the CB1 cannabinoid receptor ; AM4113 ; CB1 putative neutral antagonist ; BOLD ; blood&ndash ; oxygen-level dependent ; cAMP ; Cyclic Adenosine Monophosphate ; CB1 ; cannabinoid receptor type 1 ; CB2 ; cannabinoid receptor type 2 ; CPP ; conditioned place preference ; DBS ; deep brain stimulation ; EU ; European Union ; FDA ; Food and Drug Administration ; fMRI ; functional magnetic resonance imaging ; GABA ; gamma-aminob

刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry

出版年：3 July 2014

8.Micromolar concentrations of rimonabant directly inhibits delta opioid receptor specific ligand binding and agonist-induced G-protein activity

作者：Ferenc Zá ; dor ; ^{zador.ferenc@gmail.com" class="auth_mail} ; Dó ; ra Kocsis ; Anna Borsodi ; Sá ; ndor Benyhe

关键词：[35S]GTP纬S ; guanosine-5&prime ; -O-(3-[35S]thio)triphosphate ; BBB ; blood&ndash ; brain-barrier ; CB1 ; type 1 cannabinoid receptor ; CB1/CB2 K.O. ; CB1/CB2 double knock-out ; CB2 ; type 2 cannabinoid receptor ; CHO ; Chinese hamster ovary cell line ; CHO-mDOR ; Chinese hamster ovary cell line overexpressed with mouse 未-opioid receptor ; CHO-MOR ; Chinese hamster ovary cell line overexpressed with 渭-opioid receptor ; DMSO ; dimethyl sulphoxide ; DOR ; 未-opioid receptor ; DPDPE ; [D-Pen2 ; 5]-enkephalin hydrate ; EGTA

刊名：Neurochemistry International

出版年：February, 2014

9.Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats

作者：Elaine F. Toniolo^a ; Estê ; fani T. Maique^a ; Wilson A. Ferreira Jr.^b ; Andrea S. Heimann^c ; Emer S. Ferro^b ; Dinah L. Ramos-Ortolaza^d ; Lydia Miller^d ; Lakshmi A. Devi^d ; Camila S. Dale^e ; ^{camila.dale@usp.br" class="auth_mail} ; ^{camisdale@yahoo.com.br" class="auth_mail}

关键词：CB1 receptors ; type 1 cannabinoid receptors ; Hp ; hemopressin ; CCI ; chronic constriction injury ; PB ; phosphate buffer ; DRG ; dorsal root ganglia ; Egr1-IR ; EGR-1 immunoreactivity ; Met ; methysergide ; Yoh ; yohimbine

刊名：Peptides

出版年：June 2014

10.Identification of raloxifene as a novel CB2 inverse agonist

作者：Pritesh Kumar ; Zhao-Hui Song ; ^{zhsong@louisville.edu}

关键词：CB1 ; cannabinoid receptor 1 ; CB2 ; cannabinoid receptor 2 ; GPCR ; G protein-coupled receptor ; FDA ; food and drug administration ; HTRF ; homogenous time-resolved fluorescence

刊名：Biochemical and Biophysical Research Communications

出版年：2013

按检索点细分(97)

题名(19)

关键词(22)

文摘(74)

按出版年细分(97)

2027年及以后(6)

2016年(4)

2013年(9)

2012年(14)

2011年(3)

2010年(18)

2009年(8)

2008年(10)

2007年(6)

2006年(7)

2005年(5)

2004年(3)

2002年(1)

2001年(1)

2000年及以前(2)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700