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1.Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines

作者：Rita L. Civiello ; Xiaojun Han ; Brett R. Beno ; Prasad V. Chaturvedula ; John J. Herbst ; Cen Xu ; Charles M. Conway ; John E. Macor ; Gene M. Dubowchik

关键词：CGRP receptor antagonist ; Calcitonin gene-related peptide (CGRP) ; Migraine headache

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord

作者：Michael Milne ; John C. Ashton ; ^{john.ashton@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author}

关键词：Cannabinoid ; CGRP ; Spinal cord ; DAMGO ; WIN 55 ; 212-2

刊名：Neuroscience Letters

出版年：2016

3.Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting α7 nicotinic receptor and M4 muscarinic receptor and inhibiting CaMKIIα/CREB/CGRP signaling pathway in mice

作者：Dan Wan^a ; ¹ ; Ding Wang^a ; ¹ ; Qi Sun^b ; Yan Song^a ; YiMin Jiang^c ; RunTao Li^b ; Jia Ye^a ; ^{yejia@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Methyllycaconitine (PubChem CID ; 494471) ; Tropicamide (PubChem CID ; 5593) ; Methoctramine (PubChem CID ; 107759) ; Aspirin (PubChem CID ; 2244) ; Morphine (PubChem CID ; 5288826) ; Formalin (PubChem CID ; 712) ; Acetic acid (PubChem CID ; 176)

刊名：European Journal of Pharmacology

出版年：2016

4.Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies

作者：Silke Miller^a ; ^&dagger ; ; ^{silkem@amgen.com" class="auth_mail" title="E-mail the corresponding author} ; Hantao Liu^a ; ^&dagger ; ; Karin Warfvinge^b ; Licheng Shi^a ; Mary Dovlatyan^a ; Cen Xu^a ; Lars Edvinsson^b

关键词：BBB ; blood&ndash ; brain barrier ; BSA ; bovine serum albumin ; cAMP ; cyclic adenosine monophosphate ; CGRP ; calcitonin gene-related peptide ; CHO ; Chinese hamster ovary ; CLR ; calcitonin receptor-like receptor ; CNS ; central nervous system ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; FBS ; fetal bovine serum ; GFAP ; glial fibrillary acidic protein ; HEK ; human embryonic kidney ; HRP ; horseradish peroxidase ; IgG ; immunoglobulin G ; MAP-2 ; microtubule-associated protein 2 ; MBP

刊名：Neuroscience

出版年：2016

5.A novel 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist

关键词：AITC ; allyl-isothiocyanate ; CGRP ; calcitonin gene-related peptide ; CHO ; Chinese hamster ovary cell line ; COX ; cyclooxygenase ; CZP ; capsazepine ; D-MEM ; Dulbecco&rsquo ; s-Modified Eagle Medium ; DMSO ; dimethyl sulfoxide ; ECS ; extracellular solution ; LJP 1207 ; N&prime ; -(2-Phenylallyl)hydrazine hydrochloride ; NGF ; nerve growth factor ; PBS ; phosphate-buffered solution ; SSAO ; semicarbazide-sensitive amine-oxidase ; SZV-1287 ; 3-(4 ; 5-diphenyl-1 ; 3-oxazol-2-yl)propanal oxim ; TG ; trigeminal ganglion ; TRPV1 ; T

刊名：Neuroscience

出版年：2016

6.Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

作者：Panot Tangsucharit^a ; ^b ; Shingo Takatori^a ; ^e ; ^{stakator@cc.matsuyama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshito Zamami^d ; Mitsuhiro Goda^a ; ^f ; Poungrat Pakdeechote^c ; Hiromu Kawasaki^a ; ^e ; Fusako Takayama^a

关键词：Acetylcholine-induced vasodilatation ; CGRPergic nerves ; Muscarinic receptor subtypes ; Rat mesenteric arteries

刊名：Journal of Pharmacological Sciences

出版年：2016

7.Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles

作者：Juliano Machado^a ; Leandro H. Manfredi^a ; Wilian A. Silveira^a ; Dawit A.P. Gonç ; alves^a ; Danilo Lustrino^a ; Neusa M. Zanon^a ; Isis C. Kettelhut^a ; ^b ; Luiz C. Navegantes^a ; ^{navegantes@fmrp.com.br" class="auth_mail" title="E-mail the corresponding author}

关键词：CGRP ; Skeletal muscle ; cAMP/PKA signaling ; Autophagy ; Proteolysis

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

8.Targeting of calcitonin gene-related peptide action as a new strategy for migraine treatment

作者：Olga Kuzawińska^a ; ¹ ; Krzysztof Lis^a ; ¹ ; Grzegorz Cessak^a ; ^b ; Dagmara Mirowska-Guzel^a ; ^c ; Ewa Bałkowiec-Iskra^a ; ^b ; ^{ebalkowiec@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：Calcitonin gene-related peptide ; Migraine ; Monoclonal antibodies ; Calcitonin gene-related peptide antagonists

刊名：Neurologia i Neurochirurgia Polska

出版年：2016

9.Accelerated onset of the vesicovesical reflex in postnatal NGF-OE mice and the role of neuropeptides

作者：Beatrice Girard ; Abbey Peterson ; Susan Malley ; Margaret A. Vizzard ; ^{margaret.vizzard@uvm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Postnatal development ; Substance P ; Neurokinin-1 receptor antagonist ; Suburothelial nerve plexus

刊名：Experimental Neurology

出版年：2016

10.Prostaglandin E₂-mediated upregulation of neuroexcitation and persistent tetrodotoxin-resistant Na⁺ currents in Ah-type trigeminal ganglion neurons isolated from adult female rats

作者：H. Liu^a ; ^{liuhuahyd@sina.com" class="auth_mail" title="E-mail the corresponding author} ; S.-R. Duan^b

关键词：17β-E2 ; 17β-estradiol ; APD50 ; AP duration measured at 50% amplitude of AP ; APFT ; AP firing threshold ; APs ; action potential ; cAMP ; cyclic adenosine monophosphate ; Cap ; capsaicin ; CGRP ; calcitonin-related gene peptide ; COX ; cyclooxygenase ; EP ; subtype of PGE2 receptor ; G-1 ; GPR30-selective agonist ; G-15 ; GPR30-selective antagonist ; GPR30 ; G-protein-coupled receptor 30 ; PGE2 ; prostaglandin E2 ; TGNs ; trigeminal ganglion neurons ; TTX ; tetrodotoxin ; TTX-R ; TTX-resistent ; TTX-S ; TTX-sensitive ; UVMAX

刊名：Neuroscience

出版年：2016

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