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在“Elsevier电子期刊”中，命中：5,427条，耗时：0.040982 秒

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1.Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents

作者：Roheeth Kumar Pavana^a ; Shruti Choudhary^a ; Anja Bastian^b ; Michael A. Ihnat^c ; Ruoli Bai^d ; Ernest Hamel^d ; Aleem Gangjee^a ; ^{gangjee@duq.edu}

关键词：AA ; antiangiogenic agents ; MTA ; microtubule targeting agents ; VEGFR-2 ; vascular endothelial growth factor receptor-2 ; PDGFR-β ; platelet-derived growth factor receptor-β ; CAM ; chorioallantoic membrane ; CA ; combretastatin A-4 ; Pgp ; P-glycoprotein ; EGFR ; epidermal growth factor receptor ; TBS ; Tris-buffered saline ; HRP ; horseradish peroxidase ; PY ; phosphotyrosine

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

作者：Jinlei Bian¹ ; Tinghan Li¹ ; Tianwei Weng ; Jubo Wang ; Yu Chen ; Zhiyu Li ; ^{zhiyuli@cpu.edu.cn}

关键词：Wogonin ; QSAR ; Cytotoxic ; Flavonoid

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Real-time near-infrared bioimaging of a receptor-targeted cytotoxic dendritic theranostic agent

作者：Junchen Wu ; Yuren Zhou ; Shang Li ; Dahui Qu ; Wei-Hong Zhu ; ^{whzhu@ecust.edu.cn} ; He Tian

关键词：Substance P ; 5-fluorouracil ; Neurokinin-1 receptor ; Near-infrared imaging ; Anticancer

刊名：Biomaterials

出版年：2017

4.Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

作者：R. Brad Jones^a ; ^b ; ^c ; Stephanie Mueller^a ; ^c ; Sudha Kumari^a ; ^c ; Vlad Vrbanac^a ; ^d ; Shy Genel^e ; Andrew M. Tager^a ; Todd M. Allen^a ; Bruce D. Walker^a ; ^f ; ^g ; ^h ; Darrell J. Irvine^a ; ^c ; ^g ; ^h ; ⁱ ; ^{djirvine@mit.edu}

关键词：Drug delivery ; Cytotoxic T lymphocytes ; Lipid nanocapsules ; Immunotherapy ; T-pharmacyte

刊名：Biomaterials

出版年：2017

5.New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs

作者：Simon J.A. van Kuijk^a ; ¹ ; ^{s.vankuijk@maastrichtuniversity.nl} ; Nanda Kumar Parvathaneni^a ; ^b ; ¹ ; ^{nanda-kumar.parvathaneni@etu.umontpellier.fr} ; Raymon Niemans^a ; ¹ ; Marike W. van Gisbergen^a ; ¹ ; Fabrizio Carta^c ; Daniela Vullo^d ; Silvia Pastorekova^e ; Ala Yaromina^a ; Claudiu T. Supuran^c ; Ludwig J. Dubois^a ; ² ; Jean-Yves Winum^b ; ² ; Philippe Lambin^a ; ²

关键词：Tumor ; Hypoxia ; Carbonic anhydrase IX ; Dual-target drugs ; CAIX inhibitors ; Cytotoxic drugs

刊名：European Journal of Medicinal Chemistry

出版年：2017

6.Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents

作者：Jiyu Li^a ; ^&dagger ; ; Dian He^a ; ^&dagger ; ; Baitao Wang^a ; Ling Zhang^a ; Kun Li^a ; Qinjian Xie^b ; Lifang Zheng^a ; ^{zhenglf@lzu.edu.cn}

关键词：Mitochondrial dysfunction ; Hepatocellular carcinomas ; Hydroxycinnamic acids ; Antiproliferative activities ; Mitochondrial permeability transition pore

刊名：Acta Pharmaceutica Sinica B

出版年：2017

7.Cytotoxic activity, apoptosis induction and structure-activity relationship of 8-OR-2-aryl-3,4-dihydroisoquinolin-2-ium salts as promising anticancer agents

作者：Fang-Jun Cao¹ ; Li-Fei Zhu¹ ; Qian Kuang ; Xing-Qiang Li ; Bo-Hang Zhou ; Xin-Juan Yang ; ^{yxjsn2@163.com} ; Le Zhou ; ^{zhoulechem@nwsuaf.edu.cn}

关键词：Isoquinoline ; Benzo[c]phenanthridine alkaloid ; Cytotoxicity ; Apoptosis induction ; Structure&ndash ; activity relationship

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

8.Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines

作者：Hamidreza Akrami^a ; Maliheh Safavi^b ; Bibi Fatemeh Mirjalili^a ; Mahmood Dehghani Ashkezari^c ; Farhang Dadfar^c ; Najme Mohaghegh^a ; Saeed Emami^d ; Fahimeh Salehi^e ; Hamid Nadri^f ; Sussan K. Ardestani^e ; Loghman Firoozpour^g ; Mehdi Khoobi^h ; ⁱ ; ^{khoobi@tums.ac.ir} ; Alireza Foroumadi^g ; ^h ; ^{aforoumadi@yahoo.com}

关键词：Anticancer ; Cytotoxic agents ; Benzochromene ; Polycyclic compounds

刊名：European Journal of Medicinal Chemistry

出版年：2017

9.Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents

作者：Alexandra R. Fernandes^a ; ^b ; ^{ma.fernandes@fct.unl.pt} ; Joã ; o Jesus^a ; Pedro Martins^a ; Sara Figueiredo^a ; Daniela Rosa^a ; Luí ; sa M.R.D.R.S. Martins^b ; ^c ; Maria Luí ; sa Corvo^d ; Manuela C. Carvalheiro^d ; Pedro M. Costa^e ; Pedro V. Baptista^a ; ^{pmvb@fct.unl.pt}

关键词：Gold nanoparticles ; Targeting ; Nanomedicine ; Cancer therapy ; Metal complexes ; Colorectal cancer ; Lung cancer

刊名：Journal of Controlled Release

出版年：2017

10.Cytotoxic effect of Spirulina platensis extracts on human acute leukemia Kasumi-1 and chronic myelogenous leukemia K-562 cell lines

作者：Flor Yohana Flores Hernandez ; Sanghamitra Khandual ; ^{mita@ciatej.mx} ; Inocencia Guadalupe Ramí ; rez Ló ; pez

关键词：Leukemia ; Cytotoxicity ; Spirulina ; Carotenoids

刊名：Asian Pacific Journal of Tropical Biomedicine

出版年：2017

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