作者：Andrew M. Haidle^a ; ; Kaleen K. Childers^a ; Anna A. Zabierek^a ; Jason D. Katz^a ; James P. Jewell^a ; Yongquan Hou^a ; Michael D. Altman^a ; Alexander Szewczak^c ; Dapeng Chen^b ; Andreas Harsch^b ; Mansuo Hayashi^d ; Lee Warren^d ; Michael Hutton^d ; Hugh Nuthall^d ; Matt G. Stanton^a ; Ian W. Davies^a ; Ben Munoz^a ; Alan Northrup^a

关键词：MARK ; Kinase ; Pharmacokinetics ; Optimization ; Physical properties ; Disposition study ; In vitro&ndash ; in vivo correlation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

作者：Michael R. Wood^a ; ^c ; ¹ ; Meredith J. Noetzel^a ; ^b ; ¹ ; Michael S. Poslusney^a ; ¹ ; Bruce J. Melancon^a ; ^b ; James C. Tarr^a ; Atin Lamsal^a ; Sichen Chang^a ; Vincent B. Luscombe^a ; ^b ; Rebecca L. Weiner^a ; ^b ; Hyekyung P. Cho^a ; ^b ; Michael Bubser^a ; Carrie K. Jones^a ; ^b ; ^e ; Colleen M. Niswender^a ; ^b ; ^e ; Michael W. Wood^d ; Darren W. Engers^a ; ^b ; Nicholas J. Brandon^d ; Mark E. Duggan^d ; P. Jeffrey Conn^a ; ^b ; ^e ; Thomas M. Bridges^a ; ^b ; ^{thomas.m.bridges@vanderbilt.edu} ; Craig W. Lindsley^a ; ^b ; ^c ; ^{craig.lindsley@vanderbilt.edu}

关键词：M4 ; Muscarinic acetylcholine receptor ; Positive allosteric modulator (PAM) ; Schizophrenia ; Structure-activity relationship (SAR)

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

作者：Simone Esposito ; ^{s.esposito@irbm.it" class="auth_mail" title="E-mail the corresponding author} ; Elena Bracacel ; Martina Nibbio ; Roberto Speziale ; Laura Orsatti ; Maria Veneziano ; Edith Monteagudo ; Fabio Bonelli

关键词：Perhexiline ; LC&ndash ; HRMS ; Dilute-and-shoot ; Plasma pharmacokinetics ; Preclinical DMPK ; Orbitrap

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

作者：P.G. Bridgman^a ; ^{paul.bridgman@cdhb.health.nz" class="auth_mail" title="E-mail the corresponding author} ; J. Finsterer^b ; C. Lacey^c ; B. Kimber^c ; P.J. Parkin^d ; A.L. Miller^e ; M.A. Kennedy^e

关键词：Takotsubo cardiomyopathy ; Myotonic dystrophy type one ; Torsades de pointes ; Genetics ; Cardiac involvement

刊名：International Journal of Cardiology

出版年：2016

作者：Cristian Miere ; Heema Hewitson ; Liani Devito ; Victoria Wood ; Neli Kadeva ; Glenda Cornwell ; Stefano Codognotto ; Emma Stephenson ; Dusko Ilic ; ^{dusko.ilic@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author}

刊名：Stem Cell Research

出版年：2016

作者：Martyna O. Urbanek ; Wlodzimierz J. Krzyzosiak ; ^{wlodkrzy@ibch.poznan.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：DM ; myotonic dystrophy ; HD ; Huntington&rsquo ; s disease ; SCA ; spinocerebellar ataxia ; DRPLA ; dentatorubral-pallidoluysian atrophy ; HDL2 ; Huntington disease-like 2 ; ALS/FTD ; amyotrophic lateral sclerosis/frontotemporal dementia ; FXTAS ; fragile X-associated tremor/ataxia syndrome ; TREDs ; triplet repeat expansion diseases ; MBNL1 ; muscleblind-like 1 ; DMPK ; dystrophia myotonica protein kinase ; FISH ; fluorescence in situ hybridization ; IF ; immunofluorescence ; LNA ; locked nucleic acids ; PNA ; peptide nuc

刊名：Methods

出版年：2016

作者：Shefali Gola^a ; Asheesh Gupta^a ; ^{asheeshgupta2001@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Gaurav K. Keshri^a ; Madhu Nath^b ; Thirumurthy Velpandian^b

关键词：Chronic hypobaric hypoxia ; CYP2C9 ; Hepatic metabolism ; Ibuprofen ; Pharmacokinetics

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

作者：Massimo Santoro^a ; ^{masantoro@dongnocchi.it" class="auth_mail" title="E-mail the corresponding author} ; Luana Fontana^b ; ^{fontanaluana@libero.it" class="auth_mail" title="E-mail the corresponding author} ; Marcella Masciullo^c ; ^{m.masciullo@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author} ; Maria Laura Ester Bianchi^d ; ^{mlebianchi@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Salvatore Rossi^d ; ^{salvatorerossi309@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emanuele Leoncini^e ; ^{emanuele.leoncini@rm.unicatt.it" class="auth_mail" title="E-mail the corresponding author} ; Giuseppe Novelli^b ; ^{novelli@med.uniroma2.it" class="auth_mail" title="E-mail the corresponding author} ; Annalisa Botta^b ; ¹ ; ^{botta@med.uniroma2.it" class="auth_mail" title="E-mail the corresponding author} ; Gabriella Silvestri^d ; ¹ ; ^{gsilvestri@rm.unicatt.it" class="auth_mail" title="E-mail the corresponding author}

关键词：MIRS ; muscular impairment rating scale ; CTG ; cytosine&ndash ; thymine&ndash ; guanine ; DM1 ; myotonic dystrophy type 1 ; cDM1 ; congenital myotonic dystrophy type 1 ; DMPK ; Dystrophia myotonica protein kinase gene ; SIX5 ; SIX Homeobox 5 gene ; CUG-BP1 ; CUG RNA-binding protein ; MBNL-1 ; muscleblind-like (Drosophila) 1 protein ; MS-HRM ; methylation sensitive high resolution melting ; CpG ; cytosine-guanine ; CTCF ; CCCTC-binding factor

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2015

作者：Yang Liu^a ; ¹ ; Shiyu Jin^a ; ¹ ; Xia Peng^b ; ¹ ; Dong Lu^a ; Limin Zeng^a ; Yiming Sun^b ; Jing Ai^b ; ^{jai@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Meiyu Geng^b ; ^{mygeng@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Youhong Hu^a ; ^{yhhu@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Pyridazinone ; c-Met inhibitor ; Cyclization strategy ; Antitumor

刊名：European Journal of Medicinal Chemistry

出版年：2016

作者：Peilong Zhang^a ; ^c ; Jiaqiang Dong^b ; ^{djiaqiang@163.com" class="auth_mail" title="E-mail the corresponding author} ; Boyu Zhong^b ; Deyi Zhang^b ; Hongbin Yuan^b ; Can Jin^b ; Xiangyuan Xu^b ; Hailong Li^b ; Yong Zhou^b ; Zhi Liang^b ; Minghua Ji^b ; Tao Xu^b ; Guowei Song^b ; Ling Zhang^b ; Gang Chen^b ; Xuejing Meng^b ; Desheng Sun^b ; Joe Shih^b ; Ruihao Zhang^b ; Guojun Hou^b ; Chengcheng Wang^b ; Ying Jin^b ; Qiong Yang^b

关键词：ALK ; Kinase ; Anti-tumor ; NSCLC ; Pyrimidine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016