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在“Elsevier电子期刊”中，命中：1,042条，耗时：0.0319843 秒

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1.Neo-tanshinlactone D-ring modified novel analogues induce apoptosis in human breast cancer cell via DNA damage

作者：Biswadip Banerji^a ; ^b ; ; Sunil Kumar Killi^a ; ^&dagger ; ; Atul Katarkar^c ; ^&dagger ; ; Satadru Chatterjee^a ; Yellaiah Tangella^a ; Chandraday Prodhan^c ; Keya Chaudhuri^c

关键词：Neotanshinlactone ; γH2AX foci ; DNA damage ; HDAC ; Apoptosis

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα

作者：Lorena Infante Lara^a ; Alexis Sledge^d ; Amine Laradji^d ; Cosmas O. Okoro^d ; ^{cokoro@tnstate.edu} ; Neil Osheroff^a ; ^b ; ^c ; ^{neil.osheroff@vanderbilt.edu}

关键词：Acridin-1(2H)-ones ; DNA topoisomerase IIα ; Anticancer drugs ; Covalent poison ; DNA cleavage

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

作者：Xiquan Liang ; Jason Potter ; ^{jason.potter@thermofisher.com} ; Shantanu Kumar ; Namritha Ravinder ; Jonathan D. Chesnut

关键词：CRISPR ; clustered regularly interspaced short palindromic repeats ; CAS9 ; CRISPR associated protein ; gRNA ; guide RNA ; PAM ; protospacer adjacent motif ; RNP ; ribonucleoprotein ; HDR ; homology directed repair ; hESCs ; human embryonic stem cells ; NHEJ ; non-homologous end joining ; SNP ; single-nucleotide polymorphism

刊名：Journal of Biotechnology

出版年：2017

4.As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks

作者：Jerome Irianto¹ ; ² ; Yuntao Xia¹ ; ² ; Charlotte R. Pfeifer¹ ; ² ; ³ ; Roger A. Greenberg¹ ; ⁴ ; Dennis E. Discher¹ ; ² ; ³ ; ^{discher@seas.upenn.edu}

刊名：Biophysical Journal

出版年：2017

5.House dust mite-induced asthma causes oxidative damage and DNA double-strand breaks in the lungs

作者：Tze Khee Chan ; BSc^a ; ^b ; ^c ; Xin Yi Loh ; BSc^a ; Hong Yong Peh ; BSc^a ; ^b ; W.N. Felicia Tan ; BSc^a ; W.S. Daniel Tan ; BSc^a ; ^b ; Na Li ; PhD^c ; Ian J.J. Tay ; BEng^d ; ^e ; W.S. Fred Wong ; PhD^a ; ^b ; ^{phcwongf@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; Bevin P. Engelward ; ScD^c ; ^e

关键词：House dust mite ; asthma ; oxidative stress ; DNA double-strand breaks ; BEAS-2B ; cell death ; DNA repair ; NU7441

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

6.Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents

作者：Nicolaos-Panagiotis Andreou^a ; Konstantinos Dafnopoulos^a ; Christos Tortopidis^a ; Alexandros E. Koumbis^b ; Maria Koffa^c ; George Psomas^d ; Konstantina C. Fylaktakidou^a ; ^{kfylakta@mbg.duth.gr" class="auth_mail" title="E-mail the corresponding author}

关键词：DNA photo-cleavage ; DNA binding ; Sulfonyl ketoximes ; Sulfonyloxyl radicals ; Photo-cleavage agents

刊名：Journal of Photochemistry and Photobiology B: Biology

出版年：2016

7.The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair

作者：Maria Jasin^a ; ^{m-jasin@ski.mskcc.org" class="auth_mail" title="E-mail the corresponding author} ; James E. Haber^b ; ^{haber@brandeis.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：DSB ; double-strand break ; HR ; homologous recombination ; HDR ; homology-directed repair ; BIR ; break-induced replication ; NHEJ ; nonhomologous end-joining ; Alt-NHEJ ; alternative-NHEJ ; MMEJ ; microhomology-mediated end-joining ; ssDNA ; single-stranded DNA

刊名：DNA Repair

出版年：2016

8.Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection

作者：Roopesh Anand¹ ; ² ; Lepakshi Ranjha¹ ; ² ; Elda Cannavo¹ ; ² ; Petr Cejka¹ ; ² ; ³ ; ^{petr.cejka@irb.usi.ch}

关键词：helicase ; nuclease ; homologous recombination ; DNA end resection ; double-strand DNA break

刊名：Molecular Cell

出版年：2016

9.Design of a mononuclear copper(II)-phenanthroline complex: Catechol oxidation, DNA cleavage and antitumor properties

作者：Dhananjay Dey^a ; Subrata Das^a ; Hare Ram Yadav^b ; Anandan Ranjani^c ; Loganathan Gyathri^c ; Sanjay Roy^d ; Partha Sarathi Guin^d ; Dharumadurai Dhanasekaran^c ; Angshuman Roy Choudhury^b ; Mohammad Abdulkader Akbarsha^e ; ^f ; Bhaskar Biswas^a ; ^{mr.bbiswas@rediffmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{icbbiswas@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Copper(II) ; Crystal structure ; Catecholase activity ; DNA cleavage ; Antitumor activity

刊名：Polyhedron

出版年：2016

10.Amplified detection of nuclear factor-kappa B activity and inhibition based on exonuclease III assisted cleavage-induced DNAzyme releasing strategy

作者：Jingjing Ming^a ; ^bAuthor Vitae ; Ting-Fu Jiang^a ; ^b ; ^c ; ^{jiangtingfu@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Yuan-Hong Wang^a ; ^b ; ^cAuthor Vitae ; Zhi-Hua Lv^a ; ^b ; ^c ; ^{lvzhihua@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author}Author Vitae

关键词：Transcription factors ; Nuclear factor-kappa B ; Exonuclease III ; Fluorescence sensor ; DNAzyme

刊名：Sensors & Actuators: B. Chemical

出版年：2016

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