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Elsevier电子期刊(44)

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1.Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav_1.2 over-expressing cells

作者：Armando Lagrutta ; PhD ; ^{armando_lagrutta@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Haoyu Zeng ; PhD ; John Imredy ; PhD ; Bharathi Balasubramanian ; MS ; Spencer Dech ; MA ; Edward Lis ; BS ; Jixin Wang ; MS ; Jin Zhai ; MS ; Joseph DeGeorge ; PhD ; Frederick Sannajust ; PharmD ; PhD

关键词：AMIO ; amiodarone ; CCBs ; calcium channel blockers ; DEA ; desethylamiodarone ; DDI ; drug-drug interaction(s) ; DRON ; dronedarone ; FP ; field potential ; HCV-NI ; hepatitis-C virus nucleotide inhibitor ; hiPSC-CMs ; human induced Pluripotent Stem Cell-derived Cardiomyocytes ; IMP ; impedance ; MNI-1 ; Merck-Nucleotide Inhibitor #1 ; NCX1 ; sodium-calcium exchanger 1 ; P-gp ; P-glycoprotein ; SERCA ; sarcoplasmic-endoplasmic reticulum calcium-ATPase ; SOF ; sofosbuvir

刊名：Toxicology and Applied Pharmacology

出版年：2016

2.The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

作者：Qiangen Wu^a ; Baitang Ning^b ; Jiekun Xuan^a ; Zhen Ren^a ; Lei Guo^a ; ^{Lei.Guo@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Matthew S. Bryant^a ; ^{Matthew.Bryant@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：Amiodarone ; Desethylamiodarone ; Amiodarone metabolism ; Cytochrome P450s (CYPs) ; HepG2 cells ; HepG2 expressing CYP

刊名：Toxicology Letters

出版年：2016

3.Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

作者：Yihong Zhang^a ; Charlotte K. Colenso^b ; ¹ ; Aziza El Harchi^a ; Hongwei Cheng^a ; Harry J. Witchel^c ; Chris E. Dempsey^b ; ^{C.Dempsey@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jules C. Hancox^a ; ^{Jules.hancox@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AF ; atrial fibrillation ; diLQTS ; drug induced long QT syndrome ; DEA ; desethylamiodarone ; HEK ; human embryonic kidney ; hERG ; human-Ether-à ; -go-go-Related Gene ; IC50 ; half-maximal inhibitory concentration ; IhERG ; ionic current carried by hERG potassium channels ; IKr ; rapid delayed rectifier potassium current ; IKs ; slow delayed rectifier potassium current ; LQTS ; long QT syndrome

刊名：Biochemical Pharmacology

出版年：2016

4.Corneal Densitometry as a Novel Technique for Monitoring Amiodarone Therapy

作者：Maged Alnawaiseh ; MD¹ ; ^{maged.alnawaiseh@ukmuenster.de" class="auth_mail" title="E-mail the corresponding author} ; Lars Zumhagen ; MD ; MSc¹ ; Sven Zumhagen ; MD² ; Lea Schulte² ; André ; Rosentreter ; MD¹ ; Friederike Schubert ; MD¹ ; Nicole Eter ; MD¹ ; ^&lowast ; ; Gerold Mö ; nnig ; MD² ; ^&lowast ;

关键词：AK ; amiodarone keratopathy

刊名：Ophthalmology

出版年：2016

5.Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites

作者：Aneesh Karkhanis^a ; Hui Yuan Lam^a ; Gopalakrishnan Venkatesan^a ; Siew Kwan Koh^b ; Christina Li Lin Chai^a ; Lei Zhou^b ; Yanjun Hong^a ; Pipin Kojodjojo^c ; Eric Chun Yong Chan^a ; ^{phaccye@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author}

关键词：AA ; arachidonic acid ; ACN ; acetonitrile ; AF ; atrial fibrillation ; CYP2D6 ; cytochrome P450 2D6 ; CYP2J2 ; cytochrome P450 2J2 ; CYP3A4 ; cytochrome P450 3A4 ; CYP3A5 ; cytochrome P450 3A5 ; DDI ; drug&ndash ; drug interaction ; EET ; epoxyeicosatrienoic acid ; GSH ; glutathione ; k ; intrinsic elimination rate constant ; Ki ; reversible inhibition constant ; KI ; inactivator concentration at half-maximum inactivation rate constant ; kinact ; maximum inactivation rate constant ; Km ; Michaelis&ndash ; Menten constant ; Kobs

刊名：Biochemical Pharmacology

出版年：2016

6.Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures

作者：Giuliana Pomponio^a ; ^d ; ¹ ; Marie-Gabrielle Zurich^b ; ¹ ; Luise Schultz^c ; ¹ ; Dieter G. Weiss^c ; Luca Romanelli^d ; Alexandra Gramowski-Voss^c ; Emma Di Consiglio^a ; ^{emma.diconsiglio@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Emanuela Testai^a

关键词：AMI ; Amiodarone ; MDEA ; mono-N-desethylamiodarone ; DDEA ; di-N-desethylamiodarone ; 2D mouse model ; murine neuronal network culture in two dimensional structure ; 3D rat model ; re-aggregating rat brain cell cultures in three dimensional structure ; DIV ; days in vitro ; LDH ; lactate dehydrogenase ; CYP ; cytochrome P450 ; DMSO ; Dimethylsulfoxide ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s medium ; PBS ; phosphate buffered saline ; PNGM ; Primary Neuron Growth Medium ; PNBM ; Primary Neuron Basal Medium ; d0

刊名：Toxicology in Vitro

出版年：2015

7.In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

作者：Giuliana Pomponio^a ; ^e ; ¹ ; Camille C. Savary^b ; ¹ ; Cé ; line Parmentier^c ; ¹ ; Frederic Bois^d ; ¹ ; André ; Guillouzo^b ; Luca Romanelli^e ; Lysiane Richert^c ; ^f ; Emma Di Consiglio^a ; ^{emma.diconsiglio@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Emanuela Testai^a

关键词：AMI ; amiodarone ; MDEA ; mono-N-desethylamiodarone ; DDEA ; di-N-desethylamiodarone ; PHH ; primary human hepatocytes ; CYP ; cytochrome P450 ; DMSO ; dimetylsulfoxide ; MeOH ; methanol ; HMM ; Hepatocyte Maintenance Medium ; FCS ; fetal calf serum ; SW ; sandwich ; d0 ; day 0 ; d13 ; day 13 ; TP ; time point ; LOD ; limit of detection ; ADR ; adverse drug reactions ; PBPK ; Physiologically Based Pharmacokinetic models ; PBBK ; physiologically based biokinetic models

刊名：Toxicology in Vitro

出版年：2015

8.First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure

作者：Má ; rcio Rodrigues^a ; ^b ; ^c ; Gilberto Alves^c ; ^b ; ^{gilberto@fcsaude.ubi.pt} ; Marí ; lia Rocha^b ; ^d ; Joã ; o Queiroz^c ; Amí ; lcar Falcã ; o^a ; ^b

关键词：AM ; amiodarone ; DEA ; desethylamiodarone ; HPLC ; high-performance liquid chromatography ; IS ; internal standard ; LLE ; liquid&ndash ; liquid extraction ; LOD ; limit of detection ; LOQ ; limit of quantification ; MEPS ; microextraction by packed sorbent ; PP ; protein

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2013

9.Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells

作者：Fiona C. Roth ; Jeanne E. Mulder ; James F. Brien ; Takashi Takahashi ; Thomas E. Massey

关键词：Amiodarone ; Desethylamiodarone ; Drug interaction ; Isobologram ; Amiodarone-induced pulmonary toxicity

刊名：Chemico-Biological Interactions

出版年：2013

10.Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography–tandem mass spectrometry assay

作者：Joachim Kuhn ; Christian Gö ; tting ; Knut Kleesiek

关键词：Amiodarone ; Desethylamiodarone ; Drug monitoring ; Liquid chromatography ; Mass spectrometry ; Stable isotope dilution liquid chromatography– ; tandem mass spectrometry

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2010

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