搜索页_+Enzymatic+cleavage

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在“Elsevier电子期刊”中，命中：1,333条，耗时：0.0149933 秒

在所有数据库中总计命中：2,253条

1.Multifunctional thermoresponsive designer peptide hydrogels

作者：Luis M. De Leon-Rodriguez^a ; ^{l.deleon@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author} ; Yacine Hemar^b ; Guang Mo^c ; Alok K. Mitra^a ; Jillian Cornish^d ; Margaret A. Brimble^a ; ^b ; ^{m.brimble@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author}

关键词：Peptide ; Hydrogel ; Thermoresponsive ; Adhesion ; Enzymatic-cleavage ; Mechanical characterization

刊名：Acta Biomaterialia

出版年：2017

2.Inflammation, vitamin B6 and related pathways

作者：Per Magne Ueland^a ; ^b ; ^{per.ueland@ikb.uib.no} ; Adrian McCann^c ; Ø ; ivind Midttun^c ; Arve Ulvik^c

关键词：Vitamin B6 ; Inflammation ; Kynurenines ; Sphingosine 1-phosphate ; Transsulfuration pathway ; Glycine cleavage system (GCS) ; Serine hydroxymethyltransferase (SHMT)

刊名：Molecular Aspects of Medicine

出版年：2017

3.Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia

作者：Blake A. Winn^a ; Zhe Shi^a ; Graham J. Carlson^a ; Yifan Wang^a ; Benson L. Nguyen^a ; Evan M. Kelly^a ; R. David Ross IV^a ; Ernest Hamel^b ; David J. Chaplin^a ; ^c ; Mary L. Trawick^a ; ^{Mary_Lynn_Trawick@baylor.edu} ; Kevin G. Pinney^a ; ^{Kevin_Pinney@baylor.edu}

关键词：BAPC ; bioreductively activatable prodrug conjugate ; CA1 ; combretastatin A-1 ; CA4 ; combretastatin A-4 ; Et3N ; triethylamine ; HPLC ; high performance liquid chromatography ; HRMS ; high resolution mass spectrometry ; MeOH ; methanol ; NaBH4 ; sodium borohydride ; TLC ; thin layer chromatography ; THF ; tetrahydrofuran ; EtOAc ; ethyl acetate ; POR ; NADPH cytochrome P450 oxidoreductase ; DMP ; Dess-Martin periodinane ; DEAD ; diethylazodicarboxylate ; DIAD ; diisopropyl azodicarboxylate ; ADDP ; 1 ; 1&prime ; -(azodicarbonyl

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.C-terminally truncated constitutively active androgen receptor variants and their biologic and clinical significance in castration-resistant prostate cancer

作者：Anca Azoitei^a ; Axel S. Merseburger^b ; Beate Godau^b ; M. Raschid Hoda^b ; Evi Schmid^c ; Marcus V. Cronauer^b ; ^{marcus.cronauer@uksh.de}

关键词：aa ; amino-acids ; ADT ; androgen deprivation therapy ; AR ; androgen receptor ; ARΔLBD ; androgen receptor lacking a functional ligand binding domain ; AR-V ; AR splice variant ; BET ; bromodomain and extra-terminal ; CE ; cryptic exon ; CRPC ; castration-resistant prostate cancer ; CTC ; circulating tumor cell ; CTD ; carboxy-terminal domain ; DBD ; DNA-binding domain ; EMT ; epithelial-mesenchymal transition ; FFPE ; formalin-fixed paraffin-embedded ; HR ; hinge region ; I ; intron ; IF ; immunofluorescence ; IGF-1 ; insulin

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

5.Drug-to-antibody determination for an antibody-drug-conjugate utilizing cathepsin B digestion coupled with reversed-phase high-pressure liquid chromatography analysis

作者：Michael Adamo^a ; ^{michael.adamo@bms.com} ; Guoyong Sun^a ; Difei Qiu^b ; Joseph Valente^b ; Wenkui Lan^b ; Hangtian Song^a ; Mark Bolgar^b ; Amit Katiyar^a ; Girija Krishnamurthy^a

关键词：Cathepsin B ; DAR ; Drug to antibody ratio ; ADC ; Antibody drug conjugate

刊名：Journal of Chromatography A

出版年：2017

6.Structural insight into a novel neutral metalloproteinase from Paenibacillus spp. BD3526: Implications for mechanisms of rapid inactivation and calcium-dependent stability

作者：Feng Hang^a ; ^b ; Qinbo Wang^a ; Qing Hong^a ; Caixia Gao^a ; Hao Zhang^b ; Wei Chen^b ; ^c ; ^{chenwei66@jiangnan.edu.cn}

关键词：Paenibacillus ; Metalloproteinase ; Autoproteolysis ; Calcium

刊名：International Journal of Biological Macromolecules

出版年：2017

7.Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

作者：Travis R. Helgren^a ; Congling Chen^a ; Phumvadee Wangtrakuldee^a ; Thomas E. Edwards^b ; ^d ; Bart L. Staker^c ; ^d ; Jan Abendroth^b ; ^d ; Banumathi Sankaran^f ; Nicole A. Housley^g ; Peter J. Myler^c ; ^d ; ^e ; Jonathon P. Audia^g ; James R. Horn^a ; Timothy J. Hagen^a ; ^{thagen@niu.edu}

关键词：MetAP ; Methionine aminopeptidase ; Inhibition ; Metalloenzyme ; Epidemic typhus ; Rickettsia prowazekii ; Lung endothelial cells

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Ca_v3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells

作者：Kazuki Fukami^a ; Erina Asano^a ; Mai Ueda^a ; Fumiko Sekiguchi^a ; Shigeru Yoshida^b ; Atsufumi Kawabata^a ; ^{kawabata@phar.kindai.ac.jp}

关键词：Cav3.2 T-type calcium channel ; Prostate cancer ; Asparagine-linked glycosylation

刊名：Journal of Pharmacological Sciences

出版年：2017

9.N-[¹⁸F]-FluoropropylJDTic for κ-opioid receptor PET imaging: Radiosynthesis, pre-clinical evaluation, and metabolic investigation in comparison with parent JDTic

作者：Sé ; bastien Schmitt ; Jé ; rô ; me Delamare ; Olivier Tirel ; Fabien Fillesoye ; Martine Dhilly ; Cé ; cile Perrio ; ^{perrio@cyceron.fr}

关键词：kappa Opioid receptor ; PET imaging ; JDTic ; Fluorine-18 ; Metabolism ; N-fluoroalkylation

刊名：Nuclear Medicine and Biology

出版年：2017

10.Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development

作者：Banu Bayyurt^a ; Gizem Tincer^a ; ¹ ; Kubra Almacioglu^a ; Esin Alpdundar^b ; Mayda Gursel^b ; Ihsan Gursel^a ; ^{ihsangursel@bilkent.edu.tr}

关键词：TLR3 ; TLR9 ; Ligands ; Immunoadjuvant ; Liposomes ; Immune response ; Preventive cancer vaccine

刊名：Journal of Controlled Release

出版年：2017

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