搜索页_+Epigenetic+repression

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1.SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells

作者：Tom L. Stephen¹ ; ⁶ ; ⁷ ; Kyle K. Payne¹ ; ⁷ ; Ricardo A. Chaurio¹ ; Michael J. Allegrezza¹ ; Hengrui Zhu² ; Jairo Perez-Sanz¹ ; Alfredo Perales-Puchalt¹ ; Jenny M. Nguyen¹ ; Ana E. Vara-Ailor¹ ; Evgeniy B. Eruslanov³ ; Mark E. Borowsky⁵ ; Rugang Zhang² ; Terri M. Laufer⁴ ; Jose R. Conejo-Garcia¹ ; ⁸ ; ^{jose.conejo-garcia@moffitt.org}

刊名：Immunity

出版年：2017

2.Exosomal MicroRNA Transport from Salivary Mesenchyme Regulates Epithelial Progenitor Expansion during Organogenesis

作者：Toru Hayashi¹ ; ² ; Isabelle M.A. Lombaert¹ ; ³ ; ⁴ ; Belinda R. Hauser¹ ; Vaishali N. Patel¹ ; Matthew P. Hoffman¹ ; ⁵ ; ^{mhoffman@mail.nih.gov}

关键词：microRNA ; exosomes ; miR-133b-3p ; DIP2B ; progenitor cells ; salivary gland ; epithelial-mesenchymal interaction ; KIT ; epigenetic repression ; 5-methylcytosine

刊名：Developmental Cell

出版年：2017

3.Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease

作者：Qin Zhang¹ ; ² ; ³ ; Lin Liu¹ ; Wenjun Lin¹ ; Shasha Yin² ; Aiping Duan¹ ; Zhihong Liu¹ ; ³ ; ^{liuzhihong@nju.edu.cn} ; Wangsen Cao¹ ; ² ; ^{wangsencao@nju.edu.cn}

关键词：CKD ; DNA methylation ; epigenetics ; Klotho ; rhein

刊名：Kidney International

出版年：2017

4.Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential

作者：Anna Kazanets¹ ; ^{anna.kazanets@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author} ; Tatiana Shorstova¹ ; ^{tatiana.shorstova@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Khalid Hilmi¹ ; ^{khalid.hilmi@mail.mcgill.com" class="auth_mail" title="E-mail the corresponding author} ; Maud Marques¹ ; ^{maud.marques@mail.mcgill.ca" class="auth_mail" title="E-mail the corresponding author} ; Michael Witcher ; ^{michael.witcher@mcgill.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：Epigenetics ; Transcriptional silencing ; DNA methylation ; CTCF ; Histone methylation ; Therapeutics

刊名：Biochimica et Biophysica Acta (BBA)-Reviews on Cancer

出版年：2016

5.Cross-species analyses unravel the complexity of H3K27me3 and H4K20me3 in the context of neural stem progenitor cells

作者：Christopher T. Rhodes^a ; Richard S. Sandstrom^b ; Shu-Wei Angela Huang^a ; Yufeng Wang^a ; Gunnar Schotta^c ; Mitchel S. Berger^d ; ; Chin-Hsing Annie Lin^a ; ^e ;

关键词：Glioblastoma multiforme (GBM) ; Neural stem progenitor cells (NSPCs) ; Chromatin immunoprecipitation (ChIP) ; Cre recombinant protein ; Epigenetic repression ; Stereotaxic injection ; Trimethylation at histone 3 lysine 27 (H3K27me3) and histone 4 lysine 20 (H4K20me3) ; Enhancer of zeste (human&mdash ; gene ; EZH2 ; protein ; EZH2) (mouse&mdash ; gene ; Ezh2 ; protein ; histone-lysine N-methyltransferase EZH2) ; Suppressor of variegation homolog 1 (human&mdash ; gene ; KMT5B or SUV420H1 ; protein ; lysine methyltransfe

刊名：Neuroepigenetics

出版年：2016

6.Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart

作者：Fuxia Xiong^a ; ^b ; Thant Lin^c ; Minwoo Song^b ; Qingyi Ma^b ; Shannalee R. Martinez^b ; Juanxiu Lv^a ; ^b ; Eugenia MataGreenwood^b ; Daliao Xiao^b ; Zhice Xu^a ; ^b ; Lubo Zhang^a ; ^b ; ^{lzhang@llu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Fetal programming ; Hypoxia ; Glucocorticoid receptor ; DNA methylation

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

7.HIC1 epigenetically represses CIITA transcription in B lymphocytes

作者：Sheng Zeng^a ; ¹ ; Yuyu Yang^b ; ¹ ; Xian Cheng^a ; ^c ; ¹ ; Bisheng Zhou^a ; ¹ ; Ping Li^a ; ^d ; Yuhao Zhao^a ; Xiaocen Kong^a ; ^e ; ^{kongxiaocen2010@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yong Xu^a ; ^b ; ^{yjxu@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Transcriptional regulation ; Epigenetics ; HIC1 ; CIITA ; DNMT

刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

出版年：2016

8.Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts

作者：Pei Han^a ; ^d ; ¹ ; Wei Li^a ; ^d ; ¹ ; Jin Yang^a ; Ching Shang^a ; ^d ; Chiou-Hong Lin^d ; Wei Cheng^a ; Calvin T. Hang^a ; ^d ; Hsiu-Ling Cheng^d ; Chen-Hao Chen^d ; Johnson Wong^h ; Yiqin Xiong^d ; Mingming Zhao^e ; Stavros G. Drakos^f ; Andrea Ghetti^g ; Dean Y. Li^f ; Daniel Bernstein^e ; Huei-sheng Vincent Chen^h ; Thomas Quertermous^d ; Ching-Pin Chang^a ; ^b ; ^c ; ^{changcp@iu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Histone methylation ; DNA methylation ; Chromatin remodeling ; Gene silencing ; Myosin heavy chain ; G9a ; Dnmt ; Brg1 ; H3K9me2 ; Cardiac hypertrophy ; Cardiomyopathy ; Heart failure

刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research

出版年：2016

9.Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay

作者：Dohyun Son ; Chung Sub Kim ; Kang Ro Lee ; Hyun-Ju Park ; ^{hyunju85@skku.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Epigenetic modulator ; Fluorescence-based assay ; Quinic acid derivatives ; HDAC inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma

作者：Jessamy Tiffen^* ; ¹ ; Stephen Wilson^&dagger ; ; ¹ ; Stuart J. Gallagher^* ; Peter Hersey^* ; Fabian V. Filipp^&dagger ; ; ^{filipp@ucmerced.edu" class="auth_mail" title="E-mail the corresponding author}

刊名：Neoplasia

出版年：2016

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