搜索页_ Farnesoid X receptor (Fxr)

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在“Elsevier电子期刊”中，命中：311条，耗时：0.0299902 秒

在所有数据库中总计命中：418条

1.Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner

作者：Wenxuan Xu^a ; Chunfeng Lu^a ; Lu Yao^a ; Feng Zhang^a ; Jiangjuan Shao^a ; Shizhong Zheng^a ; ^b ; ^{nytws@163.com}

关键词：ALD ; alcoholic liver disease ; ALP ; alkaline phosphatase ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BSEP ; bile salt export pump ; CPT1 ; carnitine palmitoyltransferase I ; CYP7A1 ; cholesterol 7-alpha hydroxy-lase ; DHA ; dihydroartemisininx ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; FAS ; fatty acid synthase ; FBS ; fetal bovine serum ; FGF15 ; fibroblast growth factor 15 ; FXR ; farnesoid X receptor ; GAPDH ; Glyceraldehyde phosphate dehydrogenase ; H&E ; haematox

刊名：Toxicology and Applied Pharmacology

出版年：2017

2.Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology

作者：Ingrid T.G.W. Bijsmans^a ; Alexandra Milona^a ; Noortje Ijssennagger^a ; Ellen C.L. Willemsen^a ; José ; M. Ramos Pittol^a ; Johan W. Jonker^b ; Katja Lange^c ; Guido J.E.J. Hooiveld^c ; Saskia W.C. van Mil^a ; ^{S.W.C.vanMil@umcutrecht.nl}

关键词：ChIP ; chromatin immunoprecipitation ; DIC ; differential interference contrast ; DM ; differentiation medium ; DSG ; Di(N-succinimidyl) glutarate ; EM ; expansion medium ; Fxr ; farnesoid x receptor ; IPA ; Ingenuity Pathway Analysis ; Lxr ; Liver x receptor ; NR ; nuclear receptor ; OCA ; obeticholic acid ; Ppar ; Peroxisome proliferator-activated receptor ; RMA ; robust multiarray analysis ; Rosi ; Rosiglitazone

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2017

3.Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

作者：Alejandro Carazo^a ; Lucie Hyrsova^a ; Jan Dusek^a ; Hana Chodounska^b ; Alzbeta Horvatova^a ; Karel Berka^c ; Vaclav Bazgier^c ; Hongying Gan-Schreier^d ; Waleé ; Chamulitrat^d ; Eva Kudova^b ; Petr Pavek^a ; ^{petr.pavek@faf.cuni.cz}

关键词：BA ; bile acid ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; CYP ; cytochrome P450 ; DCA ; deoxycholic acid ; 6-ECDCA ; 6α-ethyl-chenodeoxycholic acid ; obeticholic acid ; FXR ; farnesoid X receptor ; LBD ; ligand binding domain ; LCA ; lithocholic acid ; PXR ; pregnane X receptor ; TR-FRET ; time-resolved fluorescence energy transfer ; VDR ; vitamin D receptor

刊名：Toxicology Letters

出版年：2017

4.Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension

作者：Linda Vignozzi^a ; Annamaria Morelli^b ; Ilaria Cellai^a ; Sandra Filippi^c ; Paolo Comeglio^a ; Erica Sarchielli^b ; Elena Maneschi^a ; Gabriella Barbara Vannelli^b ; Luciano Adorini^d ; Mario Maggi^a ; ^e ; ^{mario.maggi@unifi.it}

关键词：ACE2 ; angiotensin-converting enzyme 2 ; Ach ; acetylcholine ; BA ; bile acid ; BMP2 ; bone morphogenetic protein 2 ; BMPR1A ; bone morphogenetic protein receptor 1-a ; BW ; body weight ; CDCA ; chenodeoxycholic acid ; cGMP ; cyclic guanosine monophosphate ; COX2 ; cyclooxygenase-2 ; ECs ; endothelial cells ; ET-1 ; endothelin-1 ; ETA ; endothelin receptor type A ; ETB ; endothelin receptor type B ; FXR ; farnesoid X receptor ; GCSa3 ; guanylate cyclase subunit type 1a3 ; GCSb3 ; guanylate cyclase subunit type 1b3 ; IL-1β ; int

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

5.Effect of cholecystectomy on bile acids as well as relevant enzymes and transporters in mice: Implication for pharmacokinetic changes of rifampicin

作者：Fan Zhang^a ; ^b ; Hongyan Qin^b ; Yanshu Zhao^a ; ^b ; Yuhui Wei^b ; Lili Xi^b ; Zhi Rao^b ; Jianping Zhang^b ; Yanrong Ma^b ; Yingting Duan^a ; ^b ; Xinan Wu^b ; ^{xinanwu6511@126.com}

关键词：Asbt ; apical sodium-dependent bile acids transporter ; BAs ; bile acids ; Bsep ; bile salt export pump ; β-MCA ; β-muricholic acid ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; Cyp3a11 ; cytochrome P450 3a11 (human CYP3A4) ; Cyp7a1 ; cholesterol 7α-hydroxylase cytochrome P450 7a1 ; DCA ; deoxycholic acid ; Fxr ; farnesoid X receptor ; G- ; glycine conjugated bile acid ; HDCA ; hyodesoxycholic acid ; LCA ; lithocholic acid ; Mrp2 ; multidrug resistance-associated protein 2 ; NDCA ; demethylation deoxycholic acid ; NRs

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

6.Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation

作者：Yimeng Zhang ; Youwei Xu ; Yan Qi ; Lina Xu ; Shasha Song ; Lianhong Yin ; Xufeng Tao ; Yuhong Zhen ; Xu Han ; Xiaodong Ma ; Kexin Liu ; Jinyong Peng ; ^{jinyongpeng2014@163.com} ; ^{jinyongpeng2005@163.com}

关键词：Dox ; doxorubicin ; FXR ; the farnesoid X receptor ; AMPKα ; AMP- activated protein kinase α ; HO-1 ; hemeoxygenase-1 ; GST ; glutathione-s-transferase ; Nrf2 ; NF-E2-related factor 2 ; BUN ; blood urea nitrogen ; Cr ; creatinine ; HMGB1 ; high mobility group box 1 ; NF-κB ; nuclear factor kappa B ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; TNF-α ; tumor necrosis factor alpha ; siRNA ; small interfering RNA ; H12 ; helix12

刊名：Toxicology

出版年：2017

7.Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation

作者：Da-Gang Zhang^a ; ¹ ; Cheng Zhang^b ; ¹ ; Jun-Xian Wang^a ; Bi-Wei Wang^b ; Hua Wang^b ; Zhi-Hui Zhang^b ; Yuan-Hua Chen^b ; Yan Lu^c ; Li Tao^c ; Jian-Qing Wang^c ; Xi Chen^a ; ; De-Xiang Xu^b ; ^{xudex@126.com}

关键词：CCl4 ; carbon tetrachloride ; CDCA ; chenodeoxycholic acid ; ERK ; extracellular regulated protein kinase ; FXR ; farnesoid X receptor ; IkB ; inhibitor of kB ; IL ; interleukin ; KC ; keratinocyte-derived chemokine ; MAPK ; mitogen-activated protein kinase ; MCP-1 ; monocyte chemotactic protein 1 ; MIP ; macrophage inflammatory protein ; NF-κB ; nuclear factor kappa B ; OCA ; obeticholic acid ; TNF-α ; tumor necrosis factor alpha ; TUNEL ; terminal dUTP nick-end labeling ; UDCA ; ursodeoxycholic acid

刊名：Toxicology and Applied Pharmacology

出版年：2017

8.NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition

作者：Jessica Mwinyi^a ; ^{jessica.mwinyi@neuro.uu.se} ; Adrian E. Boströ ; m^a ; Claudia Pisanu^b ; Susan K. Murphy^c ; Wiebke Erhart^d ; Clemens Schafmayer^e ; Jochen Hampe^f ; Cynthia Moylan^g ; ^h ; Helgi B. Schiö ; th^a

关键词：1-25-diOH D ; dihydroxyvitamine D ; 25-OH D ; 25-hydroxyvitamin D ; APO ; apolipoprotein ; BMI ; body mass index ; ER ; endoplasmic reticulum ; FC ; free cholesterol ; FFAs ; free fatty acids ; FGF-2 ; fibroblast growth factor 2 ; FXRɑ ; farnesoid X receptor α ; HDL ; high density lipoprotein ; LDL ; low density lipoprotein ; NAFLD ; nonalcoholic fatty liver disease ; NASH ; nonalcoholic steatohepatitis ; SS ; simple steatosis ; MS ; metabolic syndrome ; LXRα ; Liver X Receptor α ; PGC-1α ; coactivator 1α ; PPAR ; peroxisome prol

刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

出版年：2017

9.Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system

作者：A. Dash^a ; ¹ ; R.A. Figler^a ; ¹ ; B.R. Blackman^b ; S. Marukian^a ; M.S. Collado^a ; M.J. Lawson^a ; S.A. Hoang^a ; A.J. Mackey^a ; D. Manka^a ; B.K. Cole^a ; R.E. Feaver^a ; A.J. Sanyal^c ; B.R. Wamhoff^a ; ^{Wamhoff@HemoShear.com}

关键词：NASH ; nonalcoholic steatohepatitis ; NAFD ; nonalcoholic fatty liver disease ; FXR ; farnesoid X receptor ; FGF19 ; fibroblast growth factor ; DMSO ; dimethyl sulfoxide ; CYP ; cytochrome P450

刊名：Toxicology in Vitro

出版年：2017

10.Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry

作者：Kiran V. Sandhu^a ; Eoin Sherwin^a ; Harrië ; t Schellekens^a ; ^b ; Catherine Stanton^a ; ^c ; ^d ; Timothy G. Dinan^a ; ^c ; John F. Cryan^a ; ^b ; ^{j.cryan@ucc.ie}

关键词：ASD ; Autism spectrum disorder ; ADHD ; Attention-deficit hyperactive disorder ; AMPK ; AMP-activated protein kinase ; ANS ; Autonomic nervous system ; BDNF ; Brain-derived neurotrophic factor ; BMI ; Body mass index ; BCFA ; Branched chain fatty acid ; CCK ; Cholecystokinin ; CNS ; Central nervous system ; CREB ; cAMP response element-binding protein ; DA ; Dopamine ; EECs ; Enteroendocrine cells ; ENS ; Enteric nervous system ; FOS ; Fructo-oligosaccharides ; FXR ; Farnesoid X receptor ; GOS ; Galacto-oligosaccharides ; GF

刊名：Translational Research

出版年：2017

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