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在“Elsevier电子期刊”中，命中：1,286条，耗时：0.0349866 秒

在所有数据库中总计命中：1,744条

1.Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists

关键词：GPR119 agonists ; 5-Nitropyrimidine ; endo-Azabicyclic alcohol ; Full agonists

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

2.Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels

作者：Hermanus Johannes Ruigrok¹ ; ² ; Guillaume Shahid¹ ; ² ; Bertrand Goudeau² ; ³ ; Florence Poulletier de Gannes¹ ; ² ; Emmanuelle Poque-Haro¹ ; ² ; Annabelle Hurtier¹ ; ² ; Isabelle Lagroye¹ ; ² ; ⁴ ; Pierre Vacher² ; ⁵ ; Sté ; phane Arbault² ; ³ ; Neso Sojic² ; ³ ; Bernard Veyret¹ ; ² ; Yann Percherancier¹ ; ² ; ^{yann.percherancier@ims-bordeaux.fr}

刊名：Biophysical Journal

出版年：2017

3.Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia

作者：Amy F.T. Arnsten^a ; ^{amy.arnsten@yale.edu" class="auth_mail" title="E-mail the corresponding author} ; Ragy R. Girgis^b ; David L. Gray^c ; Richard B. Mailman^d

关键词：D1 agonist ; D2 receptors ; Executive function ; Prefrontal cortex ; Schizophrenia ; Working memory

刊名：Biological Psychiatry

出版年：2017

4.Binding Modes of Full and Partial Agonists in the Orthosteric Binding Site of the Glycine Receptor

刊名：Biophysical Journal

出版年：2017

5.Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

作者：Zheng Li^a ; Miaobo Pan^a ; Xin Su^a ; Yuxuan Dai^a ; Mian Fu^a ; Xingguang Cai^a ; Wei Shi^a ; Wenlong Huang^a ; ^b ; ^{ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Hai Qian^a ; ^b ; ^{qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FFA1 agonist ; GPR40 ; Ligand efficiency ; Type 2 diabetes ; Pyrrole

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations

作者：Federica Ferrari^a ; Maria Camilla Cerlesi^a ; Davide Malfacini^a ; Laila Asth^b ; Elaine C. Gavioli^b ; Blair V. Journigan^c ; Uma Gayathri Kamakolanu^c ; Michael E. Meyer^c ; Dennis Yasuda^c ; Willma E. Polgar^d ; Anna Rizzi^a ; Remo Guerrini^e ; Chiara Ruzza^a ; Nurulain T. Zaveri^c ; Girolamo Calo^a ; ^{g.calo@unife.it}

关键词：NOP and classical opioid receptors ; Bioluminescence resonance energy transfer ; Calcium mobilization and mouse colon vas deferens and assays ; Receptor and [35S]GTPγS binding

刊名：European Journal of Pharmacology

出版年：2016

7.New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile

作者：Victoria Obermoser^a ; Margarethe E. Urban^b ; Manuela S. Murgueitio^c ; Gerhard Wolber^c ; Ulrich Kintscher^d ; Ronald Gust^a ; ^{ronald.gust@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author}

关键词：PPARγ ; Transactivation ; Cytotoxicity ; Binding mode ; Molecular modeling

刊名：European Journal of Medicinal Chemistry

出版年：2016

8.Novel full logistic model for estimation of the estrogenic activity of chemical mixtures

作者：Martin Ezechiá ; &scaron ; ^a ; ^b ; Tomá ; &scaron ; Cajthaml^a ; ^b ; ^{cajthaml@biomed.cas.cz" class="auth_mail" title="E-mail the corresponding author}

关键词：Concentration addition ; Estrogen receptor ; Additive effect ; Logistic curve ; Endocrine disrupting compounds ; T47D

刊名：Toxicology

出版年：2016

9.Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells

作者：Irene Ramos-Á ; lvarez ; Taichi Nakamura ; Samuel A. Mantey ; Paola Moreno ; Bernardo Nuche-Berenguer ; Robert T. Jensen ; ^{robertj@bdg10.niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：AR42J cells ; rat pancreatic acinar cells ; BALB 3T3 ; mouse MIC embryonic fibroblast cells ; Bn ; bombesin ; BnR ; bombesin receptors ; BRS-3 ; bombesin receptor subtype-3 ; BSA ; bovine serum albumin fraction V ; CNS ; central nervous system ; DMEM ; Dulbecco&rsquo ; s minimum essential medium ; h ; human ; EC50 ; concentration causing half-stimulation ; FBS ; fetal bovine serum ; GPCR ; G-protein-coupled receptor ; GRP ; gastrin-releasing peptide ; GRPR ; gastrin-releasing peptide receptor ; IC50 ; half maximal inhibitor c

刊名：Peptides

出版年：2016

10.Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

作者：Henrik H Hansen^a ; ^{hbh@gubra.dk" class="auth_mail" title="E-mail the corresponding author} ; Katrine Fabricius^a ; Pernille Barkholt^a ; Jens D. Mikkelsen^b ; Jacob Jelsing^a ; Charles Pyke^c ; Lotte Bjerre Knudsen^c ; Niels Vrang^a ; ^{niels@gubra.dk" class="auth_mail" title="E-mail the corresponding author}

关键词：Parkinson's disease ; 6-Hydroxydopamine ; Dopaminergic neuron ; Tyrosine hydroxylase ; GLP-1 receptor agonist ; Liraglutide

刊名：Brain Research

出版年：2016

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