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在“Elsevier电子期刊”中，命中：1,311条，耗时：小于0.01 秒

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1.Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice

作者：Kelly Decaluwé ; PhD¹ ; Bart Pauwels ; PhD¹ ; Charlotte Boydens ; MSc¹ ; Robrecht Thoonen ; PhD² ; Emmanuel S. Buys ; PhD³ ; Peter Brouckaert ; PhD⁴ ; ⁵ ; Johan Van de Voorde ; PhD¹ ; ^{johan.vandevoorde@UGent.be}

关键词：Soluble Guanylate Cyclase ; Apo-sGC ; Erectile Dysfunction ; Oxidative Stress ; Soluble Guanylate Cyclase Activators ; Soluble Guanylate Cyclase Stimulators

刊名：The Journal of Sexual Medicine

出版年：2017

2.Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

作者：Peter Sandner^a ; ^b ; ^{peter.sandner@bayer.com} ; Johannes Peter Stasch^a ; ^c

关键词：Soluble guanylate cyclase ; Cyclic guanosine monophosphate

刊名：Respiratory Medicine

出版年：2017

3.Rationale and study design of RESPITE: An open-label, phase 3b study of riociguat in patients with pulmonary arterial hypertension who demonstrate an insufficient response to treatment with phosphodiesterase-5 inhibitors

作者：Marius M. Hoeper^a ; ^{Hoeper.Marius@mh-hannover.de} ; James R. Klinger^b ; Raymond L. Benza^c ; Gerald Simonneau^d ; David Langleben^e ; Robert Naeije^f ; Paul A. Corris^g

关键词：Pulmonary arterial hypertension ; sGC stimulator ; Soluble guanylate cyclase ; Riociguat

刊名：Respiratory Medicine

出版年：2017

4.Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension

作者：Linda Vignozzi^a ; Annamaria Morelli^b ; Ilaria Cellai^a ; Sandra Filippi^c ; Paolo Comeglio^a ; Erica Sarchielli^b ; Elena Maneschi^a ; Gabriella Barbara Vannelli^b ; Luciano Adorini^d ; Mario Maggi^a ; ^e ; ^{mario.maggi@unifi.it}

关键词：ACE2 ; angiotensin-converting enzyme 2 ; Ach ; acetylcholine ; BA ; bile acid ; BMP2 ; bone morphogenetic protein 2 ; BMPR1A ; bone morphogenetic protein receptor 1-a ; BW ; body weight ; CDCA ; chenodeoxycholic acid ; cGMP ; cyclic guanosine monophosphate ; COX2 ; cyclooxygenase-2 ; ECs ; endothelial cells ; ET-1 ; endothelin-1 ; ETA ; endothelin receptor type A ; ETB ; endothelin receptor type B ; FXR ; farnesoid X receptor ; GCSa3 ; guanylate cyclase subunit type 1a3 ; GCSb3 ; guanylate cyclase subunit type 1b3 ; IL-1β ; int

刊名：The Journal of Steroid Biochemistry and Molecular Biology

出版年：2017

5.Drug discovery targeting heme-based sensors and their coupled activities

作者：Eduardo Henrique Silva Sousa^a ; ^{eduardohss@dqoi.ufc.br} ; Luiz Gonzaga de Franç ; a Lopes^a ; Gonzalo Gonzalez^b ; Marie-Alda Gilles-Gonzalez^b ; ^{marie-alda.gilles-gonzalez@utsouthwestern.edu}

关键词：Drug discovery ; Heme-based sensor ; Nucleotide cyclase ; Phosphodiesterase ; Histidine protein kinase ; Nuclear receptor

刊名：Journal of Inorganic Biochemistry

出版年：2017

6.RISE-SSc: Riociguat in diffuse cutaneous systemic sclerosis

作者：Oliver Distler^a ; Janet Pope^b ; Chris Denton^c ; Yannick Allanore^d ; Marco Matucci-Cerinic^e ; Janethe de Oliveira Pena^f ; Dinesh Khanna^g ; ^{khannad@med.umich.edu}

关键词：Systemic sclerosis ; Riociguat ; Soluble guanylate cyclase ; Fibrosis

刊名：Respiratory Medicine

出版年：2017

7.Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep

作者：Shanshan Yang ; Junzhen Zhang ; Kaiyuan Ji ; Dingxing Jiao ; Ruiwen Fan ; ^{ruiwenfan@163.com" class="auth_mail" title="E-mail the corresponding author} ; Changsheng Dong

关键词：cAMP ; cGMP ; Skin ; Sheep ; Soluble guanylate cyclase (sGC)

刊名：Acta Histochemica

出版年：2016

8.Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice

作者：Kabita Pradhan^a ; ¹ ; ² ; Akylbek Sydykov^a ; ¹ ; ² ; Xia Tian^a ; ¹ ; Argen Mamazhakypov^a ; ¹ ; Balram Neupane^a ; ¹ ; Himal Luitel^a ; ¹ ; Norbert Weissmann^a ; ¹ ; Werner Seeger^a ; ^b ; ¹ ; Friedrich Grimminger^a ; ¹ ; Axel Kretschmer^c ; ¹ ; Johannes-Peter Stasch^c ; ¹ ; Hossein Ardeschir Ghofrani^a ; ¹ ; Ralph Theo Schermuly^a ; ¹ ; ^{ralph.schermuly@innere.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author}

关键词：PH ; pulmonary hypertension ; LHD ; left heart disease ; CHF ; chronic heart failure ; LV ; left ventricular ; RV ; right ventricular ; NO ; nitric oxide ; sGC ; soluble guanylate cyclase ; PDE ; phosphodiesterase ; cGMP ; cyclic guanosine monophosphate ; TAC ; transverse aortic constriction ; LVEDD ; left ventricular end-diastolic diameter ; LVESD ; left ventricular end-systolic diameter ; PAAT ; pulmonary artery acceleration time ; PAET ; pulmonary artery ejection time ; RVSP ; right ventricular systolic pressure ; TAPSE

刊名：International Journal of Cardiology

出版年：2016

9.The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change

作者：Jie Pan^a ; Xiaoxue Zhang^a ; Hong Yuan^a ; Qiming Xu^b ; Huijuan Zhang^a ; Yajun Zhou^a ; Zhong-Xian Huang^a ; Xiangshi Tan^a ; ^b ; ^{xstan@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：sGC ; soluble guanylate cyclase ; NO ; nitric oxide ; FRET ; fluorescence resonance energy transfer ; H-NOX domain ; heme-NO/O2-binding domain ; PAS domain ; Per/Arnt/Sim domain ; CC ; helical domain ; Ns H-NOX ; the H-NOX domain of Nostoc sp ; FlAsH-EDT2 ; fluorescein arsenical helix binder ; GTP ; guanosine 5&prime ; -triphosphate ; cGMP ; 3&prime ; 5&prime ; -cyclic guanosine monophosphate ; DEA/NO ; diethylammonium (Z)-1-(N ; N-diethylamino) diazen-1-ium-1 ; 2-diolate ; EPR ; electron paramagnetic resonance ; ODQ ; 1H-(1

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2016

10.Effects of soluble guanylate cyclase activation on heart transplantation in a rat model

作者：Sivakkanan Loganathan ; MD^a ; ^b ; ¹ ; ^{sivakkanan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sevil Korkmaz-Icöz ; PhD^a ; ¹ ; Tamá ; s Radovits ; MD ; PhD^c ; Shiliang Li ; MD^a ; Beatrice Mikles^a ; Enikő Barnucz ; MD^a ; Kristó ; f Hirschberg ; MD ; PhD^a ; Matthias Karck ; MD^a ; Gá ; bor Szabó ; MD ; PhD^a

关键词：heart transplantation ; ischemia/reperfusion ; soluble guanylate cyclase ; soluble guanylate cyclase activation ; cinaciguat ; nitric oxide

刊名：Journal of Heart and Lung Transplantation

出版年：2015

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