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Wiley电子期刊(10)	NATURE电子期刊(8)	ACS电子期刊(83)
SpringerLink电子期刊(146)	Elsevier电子期刊(628)

在“Elsevier电子期刊”中，命中：628条，耗时：小于0.01 秒

在所有数据库中总计命中：875条

1.In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Matthew Courtney-Smith^a ; Andrea Brancale^a

关键词：Structure-based virtual screening ; HCV NS3-helicase ; Piperazine derivatives ; Anti-HCV activity ; NS3 helicase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

作者：Alan Xiangdong Wang^a ; ^{alan.wang@bms.com} ; Jie Chen^a ; Qian Zhao^a ; Li-Qiang Sun^a ; Jacques Friborg^b ; Fei Yu^b ; Dennis Hernandez^b ; Andrew C. Good^c ; Herbert E. Klei^c ; Ramkumar Rajamani^c ; Kathy Mosure^d ; Jay O. Knipe^d ; Danshi Li^d ; Jialong Zhu^d ; Paul C. Levesque^d ; Fiona McPhee^b ; Nicholas A. Meanwell^a ; Paul M. Scola^a ;

关键词：HCV NS3/4A serine protease inhibitors ; Tripeptide acylsulfonamides ; C4 aryl ; C4 hydroxy-proline ; Potent and orally bioavailable ; Cardiovascular profiles

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Identification of drug resistance and immune-driven variations in hepatitis C virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward personalized medicine

作者：Aqsa Ikram^a ; Ayesha Obaid^a ; Faryal Mehwish Awan^a ; Rumeza Hanif^b ; Anam Naz^a ; Rehan Zafar Paracha^c ; Amjad Ali^a ; Hussnain Ahmed Janjua^a ; ^{janjua.hussnain@gmail.com} ; ^{hussnain.janjua@asab.nust.edu.pk}

关键词：Direct acting antiviral drugs ; Drug resistance mutations ; Epitope mutations ; Overlap

刊名：Antiviral Research

出版年：2017

4.Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Andrea Brancale^a

关键词：Ligand-based virtual screening ; Shape-similarity search ; Novel pyrrolones ; Anti-HCV activity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

5.A profiling study of a newly developed HCVcc strain PR63cc's sensitivity to direct-acting antivirals

作者：Wanyin Tao^a ; ¹ ; Tianyu Gan^a ; ^b ; ¹ ; Jie Lu^a ; ² ; Jin Zhong^a ; ^{jzhong@sibs.ac.cn}

关键词：HCV ; DAA ; Drug resistance ; HCVcc ; Resistance-associated variants

刊名：Antiviral Research

出版年：2017

6.Large-Scale Structure-Based Prediction and Identification of Novel Protease Substrates Using Computational Protein Design

作者：Manasi A. Pethe¹ ; ² ; Aliza B. Rubenstein³ ; ⁴ ; Sagar D. Khare¹ ; ² ; ³ ; ⁴ ; ^{sagar.khare@rutgers.edu}

关键词：TEV ; tobacco etch virus protease ; HCV ; hepatitis C virus protease ; HIVPR ; human immunodeficiency virus protease 1 ; AUC ; area under curve ; ROC ; receiver operator curve ; SVM ; support vector machine ; YESS ; Yeast Endoplasmic Reticulum Sequestration and Screening ; TI ; tetrahedral intermediate

刊名：Journal of Molecular Biology

出版年：2017

7.Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir

作者：Takashi E. Komatsu¹ ; ^{takashi.komatsu@fda.hhs.gov} ; Sarita Boyd¹ ; Adam Sherwat¹ ; LaRee Tracy² ; Lisa K. Naeger¹ ; Julian J. O&rsquo ; Rear¹ ; Patrick R. Harrington¹ ; ^{patrick.harrington@fda.hhs.gov}

关键词：DAA ; Replication ; FDA ; Post-Hoc Analysis

刊名：Gastroenterology

出版年：2017

8.Effectiveness of Elbasvir and Grazoprevir Combination, With or Without Ribavirin, for Treatment-Experienced Patients With Chronic Hepatitis C Infection

作者：Paul Kwo¹ ; ^{pkwo@stanford.edu} ; Edward J. Gane² ; Cheng-Yuan Peng³ ; Brian Pearlman⁴ ; John M. Vierling⁵ ; Lawrence Serfaty⁶ ; Maria Buti⁷ ; Stephen Shafran⁸ ; Paul Stryszak⁹ ; Li Lin⁹ ; Jacqueline Gress⁹ ; Stuart Black⁹ ; Frank J. Dutko⁹ ; Michael Robertson⁹ ; Janice Wahl⁹ ; Lisa Lupinacci⁹ ; Eliav Barr⁹ ; Barbara Haber⁹

关键词：Hepatitis C ; Randomized ; Therapy ; C-EDGE Treatment-Experienced

刊名：Gastroenterology

出版年：2017

9.Engineered exosomes boost the HCV NS3-specific CD8⁺ T lymphocyte immunity in humans

作者：Simona Anticoli^a ; ^{simona.anticoli@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Emiliana Falcone^b ; ^{emiliana.falcone@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Anna Ruggieri^b ; ^{anna.ruggieri@iss.it" class="auth_mail" title="E-mail the corresponding author} ; Maurizio Federico^a ; ^{maurizio.federico@iss.it" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV ; Human hepatitis C virus ; CTLs ; cytotoxic T lymphocytes ; kDa ; kilodaltons ; VSV-G ; vesicular stomatitis virus G protein ; PBMCs ; peripheral blood mononuclear cells ; FACS ; fluorescence-activated cell sorting ; HPV ; Human Papilloma Virus ; FCS ; fetal calf serum ; APCs ; antigen-presenting cells ; CTL ; cytotoxic T lymphocytes ; TAA ; tumor-associated antigens ; iDCs ; immature dendritic cells ; AchE ; acetylcholinesterase ; PMA ; phorbol 12 myristate 13-acetate ; SD ; standard deviation ; SFU ; spot-forming units

刊名：Trials in Vaccinology

出版年：2016

10.Boceprevir plus pegylated interferon/ribavirin to re-treat hepatitis C virus genotype 1 in HIV-HCV co-infected patients: final results of the Spanish BOC HIV-HCV Study

作者：M. Laguno^a ; M.A. Von Wichmann^b ; E. Van den Eynde^c ; J. Navarro^d ; C. Cifuentes^e ; J. Murillas^f ; S. Veloso^g ; M. Martí ; nez-Rebollar^a ; ^{rebollar@clinic.cat} ; J.M. Guardiola^h ; A. Jouⁱ ; J.L. Gó ; mez-Sirvent^j ; M. Cervantes^k ; J.A. Pineda^l ; S. Ló ; pez-Calvo^m ; A. Carreroⁿ ; M.L. Montes^o ; E. Deig^p ; A. Tapiz^q ; J.D. Ruiz-Mesa^r ; A. Cruceta^a ; E. de Lazzari^a ; J. Mallolas^a

关键词：PEG-IFN/RBV ; + ; BOC therapy ; HIV&ndash ; HCV experienced patients ; HCV genotype 1 ; Re-treatment

刊名：International Journal of Infectious Diseases

出版年：2016

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