搜索页_+HCV+polymerase+inhibitor

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在“Elsevier电子期刊”中，命中：190条，耗时：0.0219915 秒

在所有数据库中总计命中：267条

1.Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

作者：Yu Cheng^a ; ^&dagger ; ; Jian Shen^b ; ^&dagger ; ; Run-Ze Peng^a ; Gui-Feng Wang^b ; Jian-Ping Zuo^b ; ^{jpzuo@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV NS5B polymerase ; 2-Alkyl quinolone ; 1 ; 6-Naphthyridine-4 ; 5-dione ; Non-nucleoside inhibitor ; Direct acting antiviral ; Allosteric site

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

2.Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

作者：Claire Pierra Rouviè ; re^a ; ^{claire.pierra-rouviere@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Agnè ; s Amador^b ; Eric Badaroux^b ; Thierry Convard^a ; Daniel Da Costa^a ; David Dukhan^a ; Ludovic Griffe^b ; Jean-Franç ; ois Griffon^a ; Massimiliano LaColla^c ; Fré ; dé ; ric Leroy^b ; Michel Liuzzi^d ; Anna Giulia Loi^d ; Joe McCarville^c ; Valeria Mascia^d ; Julien Milhau^a ; Loredana Onidi^d ; Jean-Laurent Paparin^a ; Rachid Rahali^a ; Efisio Sais^d ; Maria Seifer^c ; Dominique Surleraux^b ; David Standring^c ; Cyril Dousson^a

关键词：Hepatitis C virus ; Direct-acting antivirals ; NS5B non-nucleoside inhibitors ; Polymerase inhibitors ; Amide bioisostere ; Allosteric inhibitors

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Direct anti-HCV agents

作者：Xingquan Zhang ^{xiz002@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Hepatitis C virus ; Cure HCV ; Sustained virologic response ; Direct antiviral agents ; NS3/4A protease inhibitor

刊名：Acta Pharmaceutica Sinica B

出版年：2016

4.Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors

关键词：Hepatitis C ; HCV genotype 1b replicon ; Small molecule inhibitor ; Pyrido[2 ; 3-d]pyrimidin-7-(8H)-ones

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.Characterization of forced degradation products and in silico toxicity prediction of Sofosbuvir: A novel HCV NS5B polymerase inhibitor

作者：Debasish Swain^a ; Gananadhamu Samanthula^a ; ^{gana@niperhyd.ac.in" class="auth_mail" title="E-mail the corresponding author} ; ^{gana_pharma@rediffmail.com" class="auth_mail" title="E-mail the corresponding author} ; Shweta Bhagat^b ; P.V. Bharatam^b ; Venkatakrishna Akula^c ; Barij N. Sinha^c

关键词：Sofosbuvir ; Degradation behavior ; LC-ESI-QTOF&ndash ; MS/MS ; In silico toxicity

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

6.Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus

作者：Jie Qing^a ; ^{qing282420@163.com" class="auth_mail" title="E-mail the corresponding author} ; Rui Luo^a ; Yaxin Wang^b ; Junxiu Nong^a ; Ming Wu^a ; Yan Shao^a ; Ruoyi Tang^a ; Xi Yu^a ; Zheng Yin^b ; ^{yinzheng@mail.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yuna Sun^c ; ^{sunyn@moon.ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV ; NITD008 ; Nucleoside analog ; Polymerase

刊名：Antiviral Research

出版年：2016

7.3D-QSAR and molecular docking studies on designing inhibitors of the hepatitis C virus NS5B polymerase

作者：Wenlian Li^a ; Hongzong Si^b ; ^{sihz03@126.com" class="auth_mail" title="E-mail the corresponding author} ; Yang Li^c ; Cuizhu Ge^d ; Fucheng Song^a ; Xiuting Ma^a ; Yunbo Duan^b ; Honglin Zhai^e

关键词：Hepatitis C virus (HCV) ; NS5B polymerase inhibitors ; QSAR ; COMSIA ; Molecular docking

刊名：Journal of Molecular Structure

出版年：2016

8.Hepatitis C virus treatment update — A new era of all-oral HCV treatment

作者：Kazuaki Chayama^a ; ^b ; ^c ; ^{chayama@hiroshima-u.ac.jp} ; Michio Imamura^a ; ^b ; C. Nelson Hayes^a ; ^b

关键词：Chronic hepatitis C ; Direct acting antiviral drugs ; Nonnucleoside polymerase inhibitors ; NS5A inhibitors ; Protease inhibitors

刊名：Advances in Digestive Medicine

出版年：2016

9.Computational study on the binding and unbinding mechanism of HCV NS5B with the inhibitor GS-461203 and substrate using conventional and steered molecular dynamics simulations

作者：Dabo Pan^a ; Yuzhen Niu^a ; Lulu Ning^a ; Yang Zhang^b ; Huanxiang Liu^c ; ^{hxliu@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaojun Yao^a ; ^{xjyao@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Hepatitis C Virus NS5B RNA-dependent RNA polymerase ; GS-461203 ; Molecular dynamics simulation ; Binding free energy calculations

刊名：Chemometrics and Intelligent Laboratory Systems

出版年：2016

10.Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial

作者：Edward J. Gane¹ ; ^{edgane@adhb.govt.nz" class="auth_mail" title="E-mail the corresponding author} ; Kris V. Kowdley² ; David Pound³ ; Catherine A.M. Stedman⁴ ; Mitchell Davis⁵ ; Kyle Etzkorn⁶ ; Stuart C. Gordon⁷ ; David Bernstein⁸ ; Gregory Everson⁹ ; Maribel Rodriguez-Torres¹⁰ ; ^&dagger ; ; Naoky Tsai¹¹ ; Omer Khalid¹² ; Jenny C. Yang¹³ ; Sophia Lu¹³ ; Hadas Dvory-Sobol¹³ ; Luisa M. Stamm¹³ ; Diana M. Brainard¹³ ; John G. McHutchison¹³ ; Myron Tong¹⁴ ; Raymond T. Chung¹⁵ ; Kimberly Beavers¹⁶ ; John E. Poulos¹⁷ ; Paul Y. Kwo¹⁸ ; Mindie H. Nguyen¹⁹

关键词：Clinical Trial ; Direct-Acting Antiviral ; DAA ; Non-Genotype 1 HCV

刊名：Gastroenterology

出版年：2016

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