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Elsevier电子期刊(186)

在“Elsevier电子期刊”中，命中：186条，耗时：0.0119933 秒

在所有数据库中总计命中：239条

1.In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Matthew Courtney-Smith^a ; Andrea Brancale^a

关键词：Structure-based virtual screening ; HCV NS3-helicase ; Piperazine derivatives ; Anti-HCV activity ; NS3 helicase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Andrea Brancale^a

关键词：Ligand-based virtual screening ; Shape-similarity search ; Novel pyrrolones ; Anti-HCV activity

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

作者：Yu Cheng^a ; ^&dagger ; ; Jian Shen^b ; ^&dagger ; ; Run-Ze Peng^a ; Gui-Feng Wang^b ; Jian-Ping Zuo^b ; ^{jpzuo@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HCV NS5B polymerase ; 2-Alkyl quinolone ; 1 ; 6-Naphthyridine-4 ; 5-dione ; Non-nucleoside inhibitor ; Direct acting antiviral ; Allosteric site

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Discovery of fluorobenzimidazole HCV NS5A inhibitors

作者：John T. Randolph ; Charles A. Flentge ; Pamela Donner ; Todd W. Rockway ; Sachin V. Patel ; Lissa Nelson ; Douglas K. Hutchinson ; Rubina Mondal ; Neeta Mistry ; Thomas Reisch ; Tatyana Dekhtyar ; Preethi Krishnan ; Tami Pilot-Matias ; Deanne F. Stolarik ; David W.A. Beno ; Rolf Wagner ; Clarence Maring ; Warren M. Kati

关键词：HCV ; NS5A inhibitor ; Antiviral

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development

作者：Anilkumar G. Nair^a ; ; Qingbei Zeng^a ; Oleg Selyutin^a ; Stuart B. Rosenblum^a ; Yueheng Jiang^a ; De-Yi Yang^a ; Kerry Keertikar^a ; Guowei Zhou^a ; Michael P. Dwyer^a ; Seong Heon Kim^a ; Bandarpalle Shankar^a ; Wensheng Yu^a ; Ling Tong^a ; Lei Chen^a ; Robert Mazzola^a ; John Caldwell^a ; Haiqun Tang^a ; Melissa L. Allard^b ; Ronald N. Buckle^b ; Polivina Jolicia F. Gauuan^b ; Christian L. Holst^b ; Gregory S. Martin^b ; Kannan P. Naicker^b ; Samuel Vellekoop^b ; Sony Agrawal^a ; Rong Liu^a ; Rong Kong^a ; Paul Ingravallo^a ; Ellen Xia^a ; Ying Zhai^a ; Amin Nomeir^a ; Joseph A. Kozlowski^a

关键词：HCV ; NS5a ; Pan-genotype

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

作者：Marcella Bassetto^a ; ^{bassettom@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Pieter Leyssen^b ; Johan Neyts^b ; Mark M. Yerukhimovich^c ; David N. Frick^c ; Andrea Brancale^a

关键词：Structure-based virtual screening ; Substituted thieno-pyrimidines ; Anti-HCV activity

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors

关键词：Hepatitis C ; HCV genotype 1b replicon ; Small molecule inhibitor ; Pyrido[2 ; 3-d]pyrimidin-7-(8H)-ones

刊名：European Journal of Medicinal Chemistry

出版年：2016

8.Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity

作者：Wensheng Yu^a ; ^{wensheng.yu@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Craig A. Coburn^b ; De-Yi Yang^a ; Peter T. Meinke^a ; Michael Wong^a ; Stuart B. Rosenblum^a ; Kevin X. Chen^a ; George F. Njoroge^a ; Lei Chen^a ; Michael P. Dwyer^a ; Yueheng Jiang^a ; Anilkumar G. Nair^a ; Oleg Selyutin^a ; Ling Tong^a ; Qingbei Zeng^a ; Bin Zhong^c ; Tao Ji^c ; Bin Hu^c ; Sony Agrawal^d ; Ellen Xia^d ; Ying Zhai^d ; Rong Liu^e ; Rong Kong^e ; Paul Ingravallo^e ; Ernest Asante-Appiah^e ; Amin Nomeir^f ; James Fells^g ; Joseph A. Kozlowski^a

关键词：JPKWCAFEDISLAU-ZYADHFCISA-N ; IBDOLBGVBSCDQO-IZVAWUQISA-N ; ZKSPCLUKZOABLU-XKJABPBFSA-N ; OOZHXRDUWORKAN-XKJABPBFSA-N ; WWFRFSCWPDIAMN-JXWYWRPRSA-N ; LELKKRZWRDCCFU-HCPDLMSNSA-N ; NDRSYOCGAFKVCC-BCGBWABPSA-N ; JLMURDGFZWXTIH-CGDQROIESA-N ; OWHNOYVDOHNKNX-NNPWOPAYSA-N ; BVAZQCUMNICBAQ-PZHYSIFUSA-N

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Discovery of potent macrocyclic HCV NS5A inhibitors

作者：Wensheng Yu^a ; ^{wensheng.yu@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Bancha Vibulbhan^a ; Stuart B. Rosenblum^a ; Gregory S. Martin^b ; A. Samuel Vellekoop^b ; Christian L. Holst^b ; Craig A. Coburn^c ; Michael Wong^a ; Oleg Selyutin^a ; Tao Ji^d ; Bin Zhong^d ; Bin Hu^d ; Lei Chen^a ; Michael P. Dwyer^a ; Yueheng Jiang^a ; Anilkumar G. Nair^a ; Ling Tong^a ; Qingbei Zeng^a ; Sony Agrawal^e ; Donna Carr^e ; Laura Rokosz^e ; Rong Liu^f ; Stephanie Curry^f ; Patricia McMonagle^f ; Paul Ingravallo^f ; Fred Lahser^f ; Ernest Asante-Appiah^f ; James Fells^g ; Joseph A. Kozlowski^a

关键词：NLVCCEMTGWHLOA-LJADHVKFSA-N ; QKFUCROVTLGTAV-VOIOCNMVSA-N ; RKBPUMYHWWZKSP-SMHXBLBLSA-N ; YRBZTHLCSGOPIL-XLDGMLQKSA-N ; MJFMZTAINPXBIP-RRXVSGGESA-N ; XEUNGPJLHDBDLL-FBJYALBDSA-N ; IHWFCBNZRRITRU-BBACVFHCSA-N ; YJEVTLMDXNGQOV-BBACVFHCSA-N ; DVNZPVWITWXALC-BBACVFHCSA-N ; IDZUPWJBSHAPTE-GTKRZRNESA-N ; JWYKQMNINTXCHA-LFQBJWFLSA-N ; GEGMQEJODXOPEI-TWAWQFONSA-N ; AHJAYNBUBVVINA-RHSNAWLOSA-N ; YGCPVRARICYHGL-ZRGVHIMMSA-N ; ONHJYMFIFUQFEP-HZWDEHNZSA-N ; KJKGYZIRLQRCHG-IIFAZUGRSA-N ; DFZNYDFEIFBZRL-ZYADHFCISA-N ; UURCRTH

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors

作者：Ling Tong^a ; ^{ling.tong@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Wensheng Yu^a ; Craig A. Coburn^a ; Lei Chen^a ; Oleg Selyutin^a ; Qingbei Zeng^a ; Michael P. Dwyer^a ; Anilkumar G. Nair^a ; Bandarpalle B. Shankar^a ; Seong Heon Kim^a ; De-Yi Yang^a ; Stuart B. Rosenblum^a ; Rebecca T. Ruck^a ; Ian W. Davies^a ; Bin Hu^b ; Bin Zhong^b ; Jinglai Hao^b ; Tao Ji^b ; Shuai Zan^b ; Rong Liu^a ; Sony Agrawal^a ; Donna Carr^a ; Stephanie Curry^a ; Patricia McMonagle^a ; Karin Bystol^a ; Frederick Lahser^a ; Paul Ingravallo^a ; Shiying Chen^a ; Ernest Asante-Appiah^a ; Joseph A. Kozlowski^a

关键词：HCV NS5A inhibitor ; Elbasvir ; MK-8742 ; Direct-acting antiviral agents ; HCV infection treatment ; Indole based tetracyclic core

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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