搜索页_+HSD1+inhibitor

常用资源

电子图书

期刊论文

学位会议

外文资源

特色专题

内部出版物

Wiley电子期刊(3)	NATURE电子期刊(1)	ACS电子期刊(28)
SpringerLink电子期刊(20)	Elsevier电子期刊(126)

在“Elsevier电子期刊”中，命中：126条，耗时：0.0139931 秒

在所有数据库中总计命中：178条

1.Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC₅₀ for a proof-of-principle study

作者：Ahmed S. Abdelsamie^a ; ^b ; Chris J. van Koppen^c ; Emmanuel Bey^c ; Mohamed Salah^a ; Carsten Bö ; rger^d ; Lorenz Siebenbü ; rger^d ; Matthias W. Laschke^e ; Michael D. Menger^e ; Martin Frotscher^a ; ^{m.frotscher@mx.uni-saarland.de}

关键词：17β-Hydroxysteroid dehydrogenase type 1 ; Enzyme inhibitor ; Steroidogenic enzymes ; Estrogen-dependent disease ; Intracrinology

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1)

作者：Wanhong He^a ; Misra Gauri^b ; Tang Li^c ; Ruixuan Wang^c ; Sheng-Xiang Lin^a ; ^c ;

关键词：17β-HSD1 ; 17β-hydroxysteroid dehydrogenase type 1 ; E1 ; Estrone ; E2 ; Estradiol ; 4-Adione ; 4-androstenedione ; SDR ; short-chain dehydrogenase/reductase family ; AKR ; aldo-keto-reductase ; SUB ; substrate binding site ; NSCLC ; non-small cell lung carcinomas ; AI ; aromatase inhibitor ; COF ; cofactor binding site ; OVX ; ovariectomized

刊名：Gene

出版年：2016

3.Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

作者：Sung Bum Park^a ; Ji Seon Park^b ; Won Hoon Jung^a ; Hee Youn Kim^a ; Hyun Jung Kwak^a ; Jin Hee Ahn^a ; Kyoung-Jin Choi^a ; Yoon-Ju Na^a ; Sunhwa Choi^a ; Sang Dal Rhee^a ; ^c ; Ki Young Kim^a ; ^c ; ^d ; ^{kykim@krict.re.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：11β-Hydroxysteroid dehydrogenase type 1 ; Heme oxygenase-1 ; Lipopolysaccharide ; Anti-inflammatory effect

刊名：Journal of Pharmacological Sciences

出版年：2016

4.The 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against the insulin resistance and hepatic steatosis in db/db mice

作者：Xiaohuan Yuan^a ; Hongzhi Li^a ; He Bai^a ; Xiaojin Zhao^a ; Chunlei Zhang^a ; Haifeng Liu^a ; Yufei Zhang^a ; Binghai Zhao^a ; Yan Wu^a ; Jieting Liu^a ; Qi Xiang^b ; Biao Feng^a ; Yanhui Chu^a ; ^{yanhui_chu@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Yadong Huang^b ; ^{tydhuang@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Curcumin (PubChem CID ; 969516) ; Rosiglitazone (PubChem CID ; 77999) ; Cyclopentanone (PubChem CID ; 8452) ; Glucose (PubChem CID ; 5793) ; Insulin (PubChem CID ; 70678557) ; Cholesterol (PubChem CID ; 5997)

刊名：European Journal of Pharmacology

出版年：2016

5.Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and streptozocin

作者：Guorong Chen^a ; Rongrong Wang^b ; Hanbin Chen^b ; Liang Wu^b ; Ren-Shan Ge^c ; Yili Wang^a ; ^{wangyili@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：11β-HSD1 ; 11β-hydroxysteroid dehydrogenase 1 ; 11β-HSD2 ; 11β-hydroxysteroid dehydrogenase 2 ; ALT ; alanine aminotransferase ; Cat ; catalase ; Colla1 ; collagen ; Col3a1 ; collagen III ; Fn1 ; fibronectin 1 ; FN ; fibronectin ; G6pc ; glucose-6-phosphatase ; Gpx1 ; glutathione peroxidase 1 ; Gsta ; glutathione S-transferase ; HE ; hematoxylin-eosin ; LDL ; low density lipoprotein ; Nr3c1 ; glucocorticoid receptor ; Pck1 ; phosphoenolpyruvate carboxykinase ; Rps16 ; ribosome protein S16 ; α-SMA ; α-smooth muscle actin ; STZ ; s

刊名：Life Sciences

出版年：2016

6.Influence of sub-chronic selective 11β-hydroxysteroid dehydrogenase 1 inhibition on the hypothalamic-pituitary-adrenal axis in female cynomolgus monkeys

作者：Bradford S. Hamilton^a ; ^{bradford.hamilton@boehringer-ingelheim.com" class="auth_mail" title="E-mail the corresponding author} ; Corinna Schoelch^a ; Annette Schuler-Metz^a ; Paula Krosky^b ; Deepak S. Lala^b ; David A. Claremon^b ; Gerard M. McGeehan^b

关键词：11β-hydroxysteroid dehydrogenase 1 ; Inhibitor ; HPA ; Adipose tissue ; Liver

刊名：European Journal of Pharmacology

出版年：2016

7.Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

作者：René ; Maltais^a ; ^b ; Alexandre Trottier^a ; ^b ; Xavier Barbeau^c ; ^d ; Patrick Lagü ; e^d ; ^e ; Martin Perreault^a ; ^b ; Jean-Franç ; ois Thé ; riault^a ; ^b ; Sheng-Xiang Lin^a ; ^b ; Donald Poirier^a ; ^b ; ^{donald.poirier@crchul.ulaval.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：Steroid ; Enzyme inhibitor ; Estrogen ; Chemical synthesis ; Estradiol isomer

刊名：Journal of Steroid Biochemistry and Molecular Biology

出版年：2016

8.Identification of a novel 11β-HSD1 inhibitor from a high-throughput screen of natural product extracts

作者：Sung Bum Park^a ; ^b ; Ji Seon Park^c ; Won Hoon Jung^a ; AReum Park^a ; ^d ; Sae Rom Jo^a ; ^d ; Hee Youn Kim^a ; Sang Dal Rhee^a ; Shi Yong Ryu^a ; Hye Gwang Jeong^b ; Seongsoon Park^e ; Hyuk Lee^a ; ^d ; ^{leeh@krict.re.kr" class="auth_mail" title="E-mail the corresponding author} ; Ki Young Kim^a ; ^d ; ^{kykim@krict.re.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Tanshinone IIA(PubChem CID ; 164676) ; Isobutylmethylxanthine (PubChem CID ; 3758) ; Dexamethasone (PubChem CID ; 5743) ; Cortisone (PubChem CID ; 222786) ; Dimethyl sulfoxide (PubChem CID ; 679) ; β-Nicotinamide adenine dinucleotide 2&prime ; -phosphate reduced tetrasodium salt hydrate (PubChem CID ; 16218775) ; Carbenoxolone (PubChem CID ; 636403)

刊名：Pharmacological Research

出版年：2015

9.A potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models

关键词：11β-hydroxysteroid dehydrogenase type 1 ; Inhibitor ; Type 2 diabetes ; Glucocorticoid ; Gluconeogenesis ; Insulin resistance

刊名：European Journal of Pharmacology

出版年：2015

10.Towards the evaluation in an animal disease model: Fluorinated 17尾-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

作者：Ahmed S. Abdelsamie^a ; Emmanuel Bey^b ; Emanuele M. Gargano^a ; Chris J. van Koppen^b ; Martin Empting^c ; Martin Frotscher^a ; ^{m.frotscher@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author}

关键词：17尾-Hydroxysteroid dehydrogenase type 1 ; Interspecies differences ; Estrogen-dependent diseases ; Estrogen mimetics ; Non-steroidal inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2015

按检索点细分(126)

题名(7)

关键词(35)

文摘(87)

按出版年细分(126)

2027年及以后(10)

2017年(1)

2016年(6)

2015年(3)

2013年(9)

2012年(10)

2011年(15)

2010年(8)

2009年(16)

2008年(10)

2007年(6)

2006年(9)

2005年(3)

2004年(4)

2003年(3)

2001年(2)

2000年(1)

2000年及以前(10)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700