作者：Anita R. Iskandar^a ; ¹ ; ^{Anita.Iskandar@pmi.com} ; Carole Mathis^a ; ¹ ; ^{Carole.Mathis@pmi.com} ; Walter K. Schlage^b ; ^{WK.Schlage@t-online.de} ; Stefan Frentzel^a ; ^{Stefan.Frentzel@pmi.com} ; Patrice Leroy^a ; ^{Patrice.Leroy@pmi.com} ; Yang Xiang^a ; ^{Yang.Xiang@pmi.com} ; Alain Sewer^a ; ^{Alain.Sewer@pmi.com} ; Shoaib Majeed^a ; ^{Shoaib.Majeed@pmi.com} ; Laura Ortega-Torres^a ; ^{Laura.OrtegaTorres@pmi.com} ; Stephanie Johne^a ; ^{Stephanie.Johne@pmi.com} ; Emmanuel Guedj^a ; ^{Emmanuel.Guedj@pmi.com} ; Keyur Trivedi^a ; ^{Keyur.Trivedi@pmi.com} ; Gilles Kratzer^a ; ^{Gilles.Kratzer@gmail.com} ; Celine Merg^a ; ^{Celine.Merg@pmi.com} ; Ashraf Elamin^a ; ^{Ashraf.Elamin@pmi.com} ; Florian Martin^a ; ^{Florian.Martin@pmi.com} ; Nikolai V. Ivanov^a ; ^{Nikolai.Ivanov@pmi.com} ; Manuel C. Peitsch^a ; ^{Manuel.Peitsch@pmi.com} ; Julia Hoeng^a ; ^{Julia.Hoeng@pmi.com}

关键词：3D ; Three-dimensional ; AK ; Adenylate kinase ; BIF ; Biological impact factor ; CBF ; Ciliary beating frequency ; CCL ; Chemokine (C-C motif) ligand ; CFA ; Cell fate ; CPR ; Cell proliferation ; CS ; Cigarette smoke ; CST ; Cell stress ; CXCL ; Chemokine (C-X-C motif) ligand ; DEG ; Differentially expressed gene ; EGF ; Epidermal growth factor ; FDR ; False discovery rate ; FFT ; Fast Fourier transformation ; H&E ; Hematoxylin and eosin ; IL ; Interleukin ; IPN ; Inflammatory process networks ; MiRNA ; microRNA ; MMP ; Matrix me

刊名：Toxicology in Vitro

出版年：2017

作者：Y. Shang ; J.L. Dong ; K. Inthavong ; ^{kiao.inthavong@rmit.edu.au} ; J.Y. Tu

关键词：Wall shear stress ; CFD ; Nasal cavity ; Surface unwrapping

刊名：European Journal of Mechanics - B/Fluids

出版年：2017

作者：Lilian Cristina Pereira^a ; ^{lilianmed2005@yahoo.com.br} ; ^{lilianpereira@uniararas.br} ; Filipe Valente Duarte^b ; Ana Teresa Iná ; cio Ferreira Varela^b ; Anabela Pinto Rolo^b ; Carlos Manuel Marques Palmeira^b ; Daniel Junqueira Dorta^c

关键词：BDE-100 ; Autophagy ; Mitophagy ; HepG2 cells

刊名：Toxicology

出版年：2017

作者：Anthony C. Umeh^a ; ^b ; Luchun Duan^a ; ^b ; Ravi Naidu^a ; ^b ; ^{Ravi.Naidu@newcastle.edu.au} ; Kirk T. Semple^c

关键词：BR ; Bound Residue ; CSM ; Conceptual Site Model ; DCM ; Dichloromethane ; DCM/ACE ; Dichloromethane/Acetone ; ECETOC ; European Centre for Ecotoxicology and Toxicology of Chemicals ; EET ; Exhaustive Extraction Technique ; EHRA ; Ecological Health Risk Assessment ; ER ; Extractable Residue ; EVA ; Ethylene Vinyl Acetate ; GI ; Gastrointestinal ; HHRA ; Human Health Risk Assessment ; HOC ; Hydrophobic Organic Contaminant ; HPCD ; Hydroxypropyl-β-Cyclodextrin ; HPLC-FD ; High-performance Liquid Chromatography with Fluoresc

刊名：Environment International

出版年：2017

作者：Elizabeth A. Poore^a ; ¹ ; Dawn K. Slifka^a ; ¹ ; Hans-Peter Raué ; ^b ; Archana Thomas^b ; Erika Hammarlund^b ; Benjamin K. Quintel^a ; Lindsay L. Torrey^a ; Ariel M. Slifka^a ; Justin M. Richner^d ; Melissa E. Dubois^a ; Lawrence P. Johnson^c ; Michael S. Diamond^d ; ^e ; ^f ; ^g ; Mark K. Slifka^a ; ^b ; Ian J. Amanna^a ; ^{iamanna@najittech.com}

关键词：BDS ; bulk drug substance ; BPL ; β-propiolactone ; cGMP ; current good manufacturing practices ; DENV ; dengue virus ; DP ; drug product ; Env ; envelope protein ; FFA ; focus forming assay ; GLP ; good laboratory practices ; H2O2 ; hydrogen peroxide ; IVRP ; in vitro relative potency ; JEV ; Japanese encephalitis virus ; LOD ; limit of detection ; MAb ; monoclonal antibody ; MCB ; master cell bank ; MOI ; multiplicity of infection ; MVB ; master virus bank ; NT50 ; 50% neutralizing titer ; PFU ; plaque forming unit ; PPV ; porcin

刊名：Vaccine

出版年：2017

作者：Alema Galijatovic-Idrizbegovic^a ; ^{alema_galijatovic@merck.com} ; Judith E. Miller^a ; Wendy D. Cornell^b ; James A. Butler^c ; Gordon K. Wollenberg^a ; Frank D. Sistare^a ; Joseph J. DeGeorge^a

关键词：Toxicology studies ; Chronic ; Preclinical species ; Human safety risk

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Paul Brownbill^a ; ^b ; ^{paul.brownbill@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Igor Chernyavsky^c ; ^{igor.chernyavsky@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Barbara Bottalico^d ; ^{barbarabottalico28@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Gernot Desoye^e ; ^{gernot.desoye@medunigraz.at" class="auth_mail" title="E-mail the corresponding author} ; Stefan Hansson^d ; ^{stefan.hansson@med.lu.se" class="auth_mail" title="E-mail the corresponding author} ; Gerry Kenna^f ; ^{gerry@safermedicines.org" class="auth_mail" title="E-mail the corresponding author} ; Lisbeth E. Knudsen^g ; ^{liek@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Udo R. Markert^h ; ^{udo.markert@med.uni-jena.de" class="auth_mail" title="E-mail the corresponding author} ; Nicola Powles-Gloverⁱ ; ^{Nicola.PowlesGlover@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Henning Schneider^j ; ^{henning.schneider@hispeed.ch" class="auth_mail" title="E-mail the corresponding author} ; Lopa Leach^k ; ^{Lopa.Leach@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：PlaNet ; placentology network ; HPTSs ; human placental test systems ; FDA ; Food and Drug Administration ; EMA ; European Medicines Agency ; PLLR ; pregnancy and lactation labelling rule ; IVS ; intervillous space ; HUVEC ; human umbilical vein endothelial cell ; NET ; norepinephrine transporter ; EMT ; extra-neural monoamine transporter ; VMAT2 ; vesicular monoamine transporter 2 ; NOAEL ; no observed adverse effect level ; LOAEL ; lowest observable adverse effect level ; DART ; development and reproductive toxicology

刊名：Reproductive Toxicology

出版年：2016

作者：Jay S. Petrick ; ^{jay.s.petrick@monsanto.com} ; Gregory E. Frierdich ; Stephanie M. Carleton ; Colton R. Kessenich ; Andre Silvanovich ; Yuanji Zhang ; Michael S. Koch

关键词：dsRNA ; RNAi ; Genetically modified crop ; Plant incorporated protectant ; Gene suppression ; Biotech crop ; GM crop

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Haleh Saber ; ^{haleh.saber@fda.hhs.gov} ; Ramadevi Gudi ; Michael Manning ; Emily Wearne ; John K. Leighton

关键词：MABEL ; Immune oncology ; First-in-human dose

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

作者：Alexander Gosslau^a ; ^b ; ^{agosslau@bmcc.cuny.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Food toxicology ; Oxidative stress ; Inflammation ; In vitro ; in vivo and in silico models ; Alternative models

刊名：Food Science and Human Wellness

出版年：2016