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在“Elsevier电子期刊”中，命中：2,874条，耗时：0.0229896 秒

在所有数据库中总计命中：4,249条

1.Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution

作者：Manish Kumar Thakur^a ; ^b ; Swarnakumari Birudukota^b ; Srinivasan Swaminathan^b ; Sivarama Krishna Battula^b ; Sarvanan Vadivelu^b ; Rajiv Tyagi^b ; Ramachandraiah Gosu^a ; ^b ; ^{ramachandraiah_gosu@jubilantbiosys.com}

关键词：PTK6 ; BRK ; Tyrosine kinase ; Co-crystal structure ; Dasatinib ; Inhibitor

刊名：Biochemical and Biophysical Research Communications

出版年：2017

2.Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors

作者：Chi Zhang^a ; ^c ; ¹ ; Xin Wang^b ; ^d ; ¹ ; Hongchun Liu^b ; Minmin Zhang^b ; Meiyu Geng^b ; Liping Sun^a ; ^{chslp@cpu.edu.cn} ; Aijun Shen^b ; ^{shenaj@simm.ac.cn} ; Ao Zhang^c ; ^{aozhang@simm.ac.cn}

关键词：Diarylisoxazole ; Resorcinol ; Amino acid ; Hsp90 inhibitor ; Antiproliferative effect

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

作者：Qingyun Ren^a ; ^b ; Xinchang Liu^a ; ^b ; Zhonghua Luo^a ; Jing Li^a ; Chaolei Wang^a ; ^b ; Siegfried Goldmann^a ; ^{sigi@hecpharm.com} ; Jiancun Zhang^c ; Yingjun Zhang^a ; ^{zhangyingjun@hecpharm.com}

关键词：HBV ; Capsid assembly inhibitor ; SAR ; GLS4 ; Pharmacokinetics ; Safety evaluation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

4.Structure-based exploration and exploitation of the S₄ subsite of norovirus 3CL protease in the design of potent and permeable inhibitors

作者：Anushka C. Galasiti Kankanamalage^a ; Yunjeong Kim^b ; Athri D. Rathnayake^a ; Vishnu C. Damalanka^a ; Pathum M. Weerawarna^a ; Sean T. Doyle^a ; Amer F. Alsoudi^a ; D.M. Padmasankha Dissanayake^a ; Gerald H. Lushington^c ; Nurjahan Mehzabeen^d ; Kevin P. Battaile^e ; Scott Lovell^d ; Kyeong-Ok Chang^b ; ^{kchang@vet.ksu.edu} ; William C. Groutas^a ; ^{bill.groutas@wichita.edu}

关键词：Norovirus ; 3CL protease ; S4 subsite ; Optimization

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors

作者：Fevzi Topal^a ; Ilhami Gulcin^b ; ^c ; ^{igulcin@atauni.edu.tr} ; ^{igulcin@yahoo.com} ; Arif Dastan^b ; Murat Guney^d

关键词：Eugenol ; Carbonic anhydrase ; Acetylcholinesterase ; Enzyme purification ; Enzyme inhibition

刊名：International Journal of Biological Macromolecules

出版年：2017

6.Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid

作者：Belé ; n Martí ; nez-Gualda^a ; Liang Sun^b ; Eva Rivero-Buceta^a ; ¹ ; Aida Flores^a ; ² ; Ernesto Quesada^a ; Jan Balzarini^b ; Sam Noppen^b ; Sandra Liekens^b ; Dominique Schols^b ; Johan Neyts^b ; Pieter Leyssen^b ; Carmen Mirabelli^b ; Marí ; a-José ; Camarasa^a ; Ana San-Fé ; lix^a ; ^{anarosa@iqm.csic.es}

关键词：Antiviral agents ; AIDS ; HFMD ; HIV ; EV71 ; Tryptophan

刊名：Antiviral Research

出版年：2017

7.Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies

作者：Aamer Saeed^a ; ^{aamersaeed@yahoo.com} ; Shafi Ullah Khan^b ; Parvez Ali Mahesar^a ; Pervaiz Ali Channar^a ; Ghulam Shabir^a ; Jamshed Iqbal^b ; ^{drjamshed@ciit.net.pk}

关键词：Thiazoles ; 15-Lipoxygenase ; Bovine carbonic anhydrase II ; Docking studies

刊名：Biochemical and Biophysical Research Communications

出版年：2017

8.In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation

作者：Jennifer E. Sager^a ; Sasmita Tripathy^a ; Lauren S.L. Price^a ; Abhinav Nath^b ; Justine Chang^c ; Alyssa Stephenson-Famy^c ; Nina Isoherranen^a ; ^ni2@uw.edu

关键词：Drug-drug interactions ; CYP2D6 ; Bupropion ; Enzyme regulation ; In vitro to in vivo extrapolation

刊名：Biochemical Pharmacology

出版年：2017

9.Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease

作者：Ganyuan Xiao^a ; Yan Li^a ; Xiaoming Qiang^a ; Rui Xu^a ; Yunxiaozhu Zheng^a ; Zhongcheng Cao^a ; Li Luo^a ; Xia Yang^a ; Zhipei Sang^b ; Fu Su^a ; ^{sufu@scu.edu.cn} ; Yong Deng^a ; ^{dengyong@scu.edu.cn}

关键词：Alzheimer&rsquo ; s disease ; Chalcone carbamate derivatives ; Multifunctional agents ; Acetylcholinesterase inhibitors ; Aβ aggregation inhibitors ; Monoamine oxidase B inhibitors

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

10.Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

作者：Li Tan^a ; ^b ; ^j ; Deepak Gurbani^c ; ^j ; Ellen L. Weisberg^e ; ^f ; ^j ; Douglas S. Jones^g ; ^h ; ^j ; Suman Rao^a ; ^b ; ^g ; William D. Singer^c ; ^d ; Faviola M. Bernard^c ; ^d ; Samar Mowafy^a ; ^b ; ⁱ ; Annie Jenney^g ; Guangyan Du^a ; ^b ; Atsushi Nonami^e ; ^f ; James D. Griffin^e ; ^f ; Douglas A. Lauffenburger^h ; Kenneth D. Westover^c ; ^d ; ^{Kenneth.Westover@UTSouthwestern.edu} ; Peter K. Sorger^g ; ^{Peter_Sorger@hms.harvard.edu} ; Nathanael S. Gray^a ; ^b ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：TAK1 ; Polypharmacology ; Multitarget ; Cancer ; Cytokine secretion

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

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