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在“Elsevier电子期刊”中，命中：324条，耗时：0.0139927 秒

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1.Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

作者：Kunal Nepali^a ; ¹ ; Hsueh-Yun Lee^a ; ¹ ; Mei-Jung Lai^b ; Ritu Ojha^a ; Tung-Yun Wu^c ; Gu-Xian Wu^a ; Mei-Chuan Chen^c ; ^{mcchen1250@tmu.edu.tw} ; Jing-Ping Liou^a ; ^d ; ^{jpl@tmu.edu.tw}

关键词：Anticancer agents ; Histone deacetylase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases

作者：Sarah L. Wynia-Smith ; Brian C. Smith ; ^{brismith@mcw.edu}

关键词：Nitric oxide synthase ; Nitric oxide ; S-nitrosation ; S-nitrosylation ; Nitrosothiol

刊名：Nitric Oxide

出版年：2017

3.Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kδ inhibitors

作者：Ina Terstiege^a ; ^{Ina.Terstiege@astrazeneca.com} ; Matthew Perry^a ; Jens Petersen^b ; Christian Tyrchan^a ; Tor Svensson^a ; Helena Lindmark^b ; Linda Ö ; ster^b

关键词：Phosphoinositide 3-kinase ; PI3Kδ inhibitor ; Aminopyrazine ; Inflammation

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

4.Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds

作者：Adel S. El-Azab^a ; ^b ; ^{adelazaba@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Alaa A.-M. Abdel-Aziz^a ; ^c ; Rezk R. Ayyad^d ; Mariangela Ceruso^e ; Claudiu T. Supuran^e ; ^{claudiu.supuran@unifi.it" class="auth_mail" title="E-mail the corresponding author}

关键词：Carbonic anhydrase ; Sulfonamide ; Carboxylic acid ; Isoform-selectivity

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms

作者：Simone Carradori^a ; Daniela Secci^b ; ^{daniela.secci@uniroma1.it" class="auth_mail" title="E-mail the corresponding author} ; Celeste De Monte^b ; Adriano Mollica^a ; Mariangela Ceruso^c ; Atilla Akdemir^d ; Anatoly P. Sobolev^e ; Rossella Codispoti^b ; Federica De Cosmi^b ; Paolo Guglielmi^b ; Claudiu T. Supuran^c ; ^f ; ^{claudiu.supuran@unifi.it" class="auth_mail" title="E-mail the corresponding author}

关键词：Saccharin ; Acesulfame ; Carbonic anhydrase inhibitor ; Cancer-related isoforms ; N/O-substitution

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

6.Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII

作者：Satish Kumar^a ; Mariangela Ceruso^b ; Tiziano Tuccinardi^c ; Claudiu T. Supuran^b ; ^{claudiu.supuran@unifi.it" class="auth_mail" title="E-mail the corresponding author} ; Pawan K. Sharma^a ; ^{pksharma@kuk.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Carbonic anhydrase isoforms ; Pyrazolylbenzo[d]imidazoles ; Acetazolamide ; Inhibition constant (Ki)

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC

作者：Marialuigia Fantacuzzi ; ^{marialuigia.fantacuzzi@unich.it" class="auth_mail" title="E-mail the corresponding author} ; Cristina Maccallini ; Mauro Di Matteo ; Alessandra Ammazzalorso ; Isabella Bruno ; Barbara De Filippis ; Letizia Giampietro ; Adriano Mollica ; Rosa Amoroso

关键词：High-performance liquid chromatography ; Nitric Oxide Synthase inhibitor ; Acetamidine ; Fluorescence detection ; OPA/NAC derivatization

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

8.Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111

作者：Carrie L. Lomelino^a ; Brian P. Mahon^a ; Robert McKenna^a ; ^{rmckenna@ufl.edu" class="auth_mail" title="E-mail the corresponding author} ; Fabrizio Carta^b ; ^c ; Claudiu T. Supuran^b ; ^c ; ^{claudiu.supuran@unifi.it" class="auth_mail" title="E-mail the corresponding author}

关键词：Carbonic anhydrase ; Sulfonamide ; Ureido ; Thioureido ; X-ray crystallography

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain

关键词：Chronic pain ; NMDA ; GluN2B ; Nav1.8 ; Nav1.7 ; Substituted aminoquinoline

刊名：European Journal of Pharmacology

出版年：2016

10.1,4-Disubstituted aromatic piperazines with high 5-HT_2A/D₂ selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation

作者：Dorothee Mö ; ller^a ; Ismail Salama^a ; ^b ; ^{ismail_mohamed@pharm.suez.edu.eg" class="auth_mail" title="E-mail the corresponding author} ; Ralf C. Kling^a ; Harald Hü ; bner^a ; Peter Gmeiner^a ; ^{peter.gmeiner@fau.de" class="auth_mail" title="E-mail the corresponding author}

关键词：3D-QSAR ; D2 partial agonist ; CoMFA ; CoMSIA ; GPCR ; Subtype selectivity ; 5-HT2A/D2 selectivity ; Dopamine receptor ; Serotonin receptor ; Phenylpiperazine ; 1 ; 4-DAP

刊名：Bioorganic & Medicinal Chemistry

出版年：2015

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